Compare Byetta vs. Humalog

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Byetta
(Exenatide)

Humalog
(Insulin Lispro)

Lowers blood sugar. Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.Lowers blood sugar. Humalog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
Reviews & ratings
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Have you used Byetta (Exenatide)?
Worth itNot sureNot worth it
Reviews for Humalog
64%
-14% worse vs. Byetta
50%
Same vs. Byetta
16%
+16% better vs. Byetta
280 reviews
Have you used Humalog (Insulin Lispro)?
Worth itNot sureNot worth it
Side effects
ByettaHumalog
  • Low blood sugar 11%
  • Gas 1%
  • Gastroesophageal reflux disease (GERD) 1%
  • Loss of appetite 3%
  • Abdominal swelling 3%
  • Weakness 4%
  • Indigestion 5%
  • Constipation 8%
  • Headache 10%
  • Vomiting 14%
More Byetta side effects »
  • Nausea 6%
  • Surgical procedure 6%
  • Fever 6%
  • Dysmenorrhea 6%
  • Urinary tract infection 6%
  • Abdominal pain 7%
  • Asthenia 7%
  • Bronchitis 7%
  • Myalgia 7%
  • Accidental injury 9%
More Humalog side effects »
How it works
ByettaHumalog
Byetta (Exenatide) enhances the release of insulin in your gut and pancreas to lower your blood sugar.Humalog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.
Type of medication
ByettaHumalog
Prescription onlyNo lower cost generic availablePrescription onlyNo lower cost generic available
Available as
ByettaHumalog
  • Injection
  • Injection
Used for
ByettaHumalog
Risk factors for serious side effects
ByettaHumalog
  • Severe renal impairment
  • End-stage renal disease
  • Severe gastrointestinal disease
  • Gastroparesis
Detailed Byetta (Exenatide) risks & warnings »
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
Detailed Humalog (Insulin Lispro) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
ByettaHumalog
No food related info.
  • Short-acting insulin good for blood sugar control around meal times.
Kidneys and liver
ByettaHumalog
  • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
Pain
ByettaHumalog
  • Using Byetta (Exenatide) has been associated with stomach pain, nausea, vomiting and diarrhea. If you have severe gastrointestinal disease such as Crohn’s Disease or Ulcerative Colitis, you should talk to your doctor about using a different medicine for diabetes. You should not use Byetta (Exenatide) if you have gastroparesis, a condition that causes slow or irregular digestion. Gastroparesis can be common for people that have had uncontrolled diabetes for a while.
No pain related info.
Weight
ByettaHumalog
No weight related info.
  • Can cause weight gain and low blood sugar.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
Upsides and benefits
ByettaHumalog
  • Can lower your A1c (average blood sugar over time) by 1%.
  • Not as likely to cause very low blood sugar as glyburine or insulin.
  • Does not increase your appetite like other anti-diabetic medicines.
  • Pen is dialed to a single dose for easy injections.
  • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
  • Humalog is a fast-acting insulin that provides sugar control after meals.
  • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
Downsides and risks
ByettaHumalog
  • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
  • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
  • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
  • You have to take insulin by injection.
  • You have to check your blood sugar multiple times every day, usually before each meal.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
Tips from our pharmacists for people taking the medication
ByettaHumalog
  • Inject into your belly, thighs, or upper arms within an hour of your main meals.
  • Store unused pens in the refrigerator.
  • After first use, pens can be kept at room temperature for 30 days.
  • Change the needle and prime the pen every time you inject.
  • If you're also on insulin, don't inject into the same site.
  • Best to check your blood sugar once a day to make sure your medicine is working properly.
  • Short-acting insulin good for blood sugar control around meal times.
  • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
  • Can cause weight gain and low blood sugar.
  • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
  • Always have a good source of sugar nearby for low blood sugar episodes.
  • Make sure you understand how to give yourself the injections.
  • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
  • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
  • Check your blood sugar levels every day.
Learn more
More about ByettaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Byetta (Exenatide)?
Worth itNot sureNot worth it
More about HumalogSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Humalog (Insulin Lispro)?
Worth itNot sureNot worth it