Compare Byetta vs. Janumet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Byetta
(Exenatide)

Janumet
(Sitagliptin / Metformin)

Lowers your blood sugar. Byetta (Exenatide) helps lower blood sugar for people with diabetes and causes weight loss, but it has to be given by injection and many people have upset stomach.Lowers blood sugar. Janumet is an expensive but very effective combination of oral blood sugar-lowering medicines.
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Reviews & ratings
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Reviews for Janumet (Sitagliptin / Metformin)
44%
56% vs. Byetta (Exenatide)
36%
64% vs. Byetta (Exenatide)
16%
16% vs. Byetta (Exenatide)
Side effects
ByettaJanumet
  • Low blood sugar 33%
  • Nausea 26%
  • Vomiting 14%
  • Headache 10%
  • Diarrhea 10%
  • Constipation 8%
  • Indigestion 6%
  • Feeling jittery 5%
  • Muscle weakness 4%
  • Dizziness 3%
More Byetta side effects »
  • Diarrhea 4%
  • Nausea 4%
  • Headache 3%
  • Abdominal pain 1%
  • Ear, nose, or throat infection 1%
More Janumet side effects »
How it works
ByettaJanumet
Byetta (Exenatide) is a medication for diabetes. It stimulates your body to produce and release more insulin, lower the sugar hormone (glucagon), and slow down digestion.Janumet is an antidiabetic combination medicine. Metformin lowers the amount of sugar your body produces, and sitagliptin helps your body release more insulin.
Type of medication
ByettaJanumet
Anti-diabetic
Incretin mimetic
Prescription only
Anti-diabetic
DPP-4 inhibitor
Biguanide
Prescription only
Available as
ByettaJanumet
  • Injection
  • Pill
  • Extended release
Used for (click to learn more)
ByettaJanumet
Risk factors for serious side effects
ByettaJanumet
        • Severe renal impairment
        • End-stage renal disease
        • Severe gastrointestinal disease
        • Gastroparesis
          Detailed Byetta (Exenatide) risks & warnings »
          • Kidney problems
          • Liver problems
          • Congestive heart failure
          • Contrast dye for procedure
          • Surgery
          • Alcohol use
                Detailed Janumet (Sitagliptin / Metformin) risks & warnings »
                Pregnancy category
                ByettaJanumet
                CFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                BFDA pregnancy category (Probably safe)

                Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                See the FDA package insert
                Alcohol
                No specific alcohol-related info.No specific alcohol-related info.
                Food
                • Give injections in your belly, thighs, or upper arm within an hour of your two main meals of the day (separate doses by 6 or more hours).
                • Eat regular, balanced meals to avoid low blood sugar.
                • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
                Kidneys and liver
                • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
                • People with poor kidney function can't use it.
                • Janumet (Sitagliptin / Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Janumet (Sitagliptin / Metformin). It may not be a good choice for people with kidney problems. Janumet (Sitagliptin / Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
                Sex
                No specific sex-related info.No specific sex-related info.
                Sleep
                No specific sleep-related info.No specific sleep-related info.
                Weight
                • Can lower your appetite by making you feel full. Some people also lose weight when taking Byetta (Exenatide).
                • Doesn't cause weight gain or low blood sugar.
                Upsides and benefits
                ByettaJanumet
                • Lowers A1c levels by 1% (A1c measures your average blood sugar over time.)
                • Prevents the harmful effects of high sugar levels on your organs.
                • Has a lower chance of causing low blood sugar than medications like glyburide or insulin.
                • Can lower your appetite by making you feel full. Some people also lose weight when taking Byetta (Exenatide).
                • Byetta (Exenatide) is not a replacement for diabetes pills, but you may be able to use it alone without the need for pills.
                • The injectable “pen” has easy to use doses which you may find more convenient than other types of injections.
                • 2-in-1 combination medicine. If you need more than one blood sugar medicine, this lowers the number of pills you have to take.
                • Lowers A1c levels by 1-2.5%. (Hemoglobin A1c measures your average blood sugar over time.)
                • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
                • Doesn't cause weight gain or low blood sugar.
                • You don't have to check your blood sugar every day with this medicine.
                Downsides and risks
                ByettaJanumet
                • Only lowers A1c levels by 1%, which may not be enough to get your blood sugar in the safe range.
                • Byetta (Exenatide) must be injected twice a day.
                • Up to 40% of people taking Byetta (Exenatide) have upset stomach and side effects like nausea, vomiting, diarrhea, constipation, or indigestion.
                • Because Byetta (Exenatide) can interact with antibiotics and birth control pills, you can't take it until one hour after these medications.
                • Other diabetes medications work as well and are cheaper.
                • Likely expensive since there's no generic version available.
                • The metformin part of Janumet can cause nausea, indigestion, or diarrhea for most people in the first few weeks.
                • People with poor kidney function can't use it.
                • The sitagliptin part of Janumet can cause some people to have frequent throat infections or nasal congestion.
                • Might raise the risk of problems with your pancreas.
                Tips from our pharmacists for people taking the medication
                ByettaJanumet
                • Store in the refrigerator until opening. Do not freeze.
                • Give injections in your belly, thighs, or upper arm within an hour of your two main meals of the day (separate doses by 6 or more hours).
                • Change the needle and prime the pen every time you inject.
                • It’s not safe to share this medication with other people, even if you change the needle.
                • Don’t mix with insulin; give separate injections. Can be given at the same time as insulin, but in different injection areas.
                • Eat regular, balanced meals to avoid low blood sugar.
                • It's best to check your blood sugar at least once a day using a home blood sugar monitor to make sure your medication is working and is safe. Some people may need to test more often, ask your doctor.
                • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
                • May cause headaches and cold-like symptoms.
                • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
                • Can be expensive depending on insurance coverage.
                • Check your blood sugar regularly.
                Learn more
                More about ByettaSide effectsReviews & ratingsAlternativesFDA package insert
                More about JanumetSide effectsReviews & ratingsAlternativesFDA package insert