Compare Byetta vs. Janumet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Byetta (Exenatide)

Prescription only
Lowers blood sugar.

Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.

Lowers your blood sugar.

Janumet is a combination of two anti-diabetic medicines that work better together, but is available as brand only.

4.5/ 7 average rating with 79 reviewsforJanumet
Upsides
  • Can lower your A1c (average blood sugar over time) by 1%.
  • Not as likely to cause very low blood sugar as glyburine or insulin.
  • Does not increase your appetite like other anti-diabetic medicines.
  • Pen is dialed to a single dose for easy injections.
  • This 2-in-1 combination can lower the number of pills you have to take daily.
  • Lowers A1c (average blood sugar over time) up to 2.5%.
  • Available in extended and immediate release forms to allow better control of your blood sugar.
  • Doesn't increase your appetite unlike other anti-diabetic medicines.
  • Does not cause hypoglycemia or very low blood sugar.
Downsides
  • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
  • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
  • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
  • Available as brand name only and may be expensive.
  • Metformin component usually causes upset stomach.
  • Sitagliptin component may increase your risk for throat infections and inflammation of pancreas.
  • Not appropriate for those with poor kidney function.
Used for
Dosage forms
  • Injection
  • Pill
  • Extended release
Price
Lowest price near you
$644.4
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Lowest price near you
$415.3
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Reviews
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79 
46%
think this treatment is worth it
38%
think this treatment works well
15%
think this treatment is a hassle

Have you used Janumet (sitagliptin / metformin)?

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Side effects
3possible side effects
  • Nausea
    8%
  • Vomiting
    4%
  • Upset stomach
    3%
See more detailed side effects
The Janumet (sitagliptin / metformin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Kidney problems

    Severe renal impairment

    ...and 1 more risk factors

  • Serious stomach problems

    Severe gastrointestinal disease

    ...and 1 more risk factors

See more detailed risks and warnings
  • Excess lactic acid in the blood

    Kidney problems

    ...and 5 more risk factors

See more detailed risks and warnings