Compare Byetta vs. Nesina

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Lowers blood sugar. Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.Lowers your blood sugar. alogliptin is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.
Reviews & ratings
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Have you used Byetta (exenatide)?
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Have you used Nesina (alogliptin)?
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Side effects
  • Low blood sugar 11%
  • Nausea 33%
  • Diarrhea 10%
  • Vomiting 14%
  • Headache 10%
  • Constipation 8%
  • Indigestion 5%
  • Weakness 4%
  • Abdominal swelling 3%
  • Loss of appetite 3%
More Byetta side effects »

We haven’t found good data for Nesina side effects.

FDA side effect reports for Nesina »
How it works
Byetta (Exenatide) enhances the release of insulin in your gut and pancreas to lower your blood sugar.alogliptin is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.
Type of medication
Prescription only
Available as
  • Injection
  • Pill
Used for
  • Diabetes Mellitus Type 2
Risk factors for serious side effects
  • Severe renal impairment
  • End-stage renal disease
  • Severe gastrointestinal disease
  • Gastroparesis
Detailed Byetta (exenatide) risks & warnings »
    Detailed Nesina (alogliptin) risks & warnings »

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Kidneys and liver
    • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
    No kidneys and liver related info.
    • Using Byetta (Exenatide) has been associated with stomach pain, nausea, vomiting and diarrhea. If you have severe gastrointestinal disease such as Crohn’s Disease or Ulcerative Colitis, you should talk to your doctor about using a different medicine for diabetes. You should not use Byetta (Exenatide) if you have gastroparesis, a condition that causes slow or irregular digestion. Gastroparesis can be common for people that have had uncontrolled diabetes for a while.
    No pain related info.
    Upsides and benefits
    • Can lower your A1c (average blood sugar over time) by 1%.
    • Not as likely to cause very low blood sugar as glyburine or insulin.
    • Does not increase your appetite like other anti-diabetic medicines.
    • Pen is dialed to a single dose for easy injections.
    • Oral blood sugar-lowering medicine.
    • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
    • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
    • Rarely causes low blood sugar.
    • Patients taking alogliptin had less cold symptoms than patients taking Januvia.
    Downsides and risks
    • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
    • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
    • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
    • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
    • Likely expensive since there's no generic version available.
    • Some people might get frequent throat infections or nasal congestion.
    Tips from our pharmacists for people taking the medication
    • Inject into your belly, thighs, or upper arms within an hour of your main meals.
    • Store unused pens in the refrigerator.
    • After first use, pens can be kept at room temperature for 30 days.
    • Change the needle and prime the pen every time you inject.
    • If you're also on insulin, don't inject into the same site.
    • Best to check your blood sugar once a day to make sure your medicine is working properly.
    • Can cause headache and cold-like symptoms.
    • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
    • Can be expensive depending on insurance coverage.
    • Check your blood sugar regularly.
    Learn more
    More about ByettaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Byetta (exenatide)?
    Worth itNot sureNot worth it
    More about NesinaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Nesina (alogliptin)?
    Worth itNot sureNot worth it