Compare Bystolic vs. Lisinopril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Bystolic
(Nebivolol)

Zestril
(Lisinopril)

Lowers blood pressure and controls heart rate. Bystolic (Nebivolol) is a good blood pressure-lowering medicine for people with heart conditions, and has fewer side effects than other beta blockers, but it's expensive. You can't miss doses.Lowers blood pressure. Zestril (Lisinopril) is a good blood pressure-lowering medicine that protects kidney function.
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Reviews & ratings
Button Group. All currently active
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4.76056338028169Bystolic
Reviews for Bystolic (Nebivolol)
51%
of people say Bystolic (Nebivolol) is worth it
46%
say it works well
18%
say it's a big hassle
Reviews for Zestril (Lisinopril)
61%
+10% vs. Bystolic (Nebivolol)
51%
+5% vs. Bystolic (Nebivolol)
13%
+5% vs. Bystolic (Nebivolol)
Side effects
BystolicLisinopril
  • Fatigue 4%
  • Headache 3%
  • Dizziness 2%
  • Diarrhea 1%
More Bystolic side effects »
  • Dizziness 7%
  • Headache 4%
  • Cough 3%
  • Diarrhea 2%
  • Chest pain 2%
  • Fatigue 2%
  • Upper respiratory infection 1%
More Lisinopril side effects »
How it works
BystolicLisinopril
Bystolic (Nebivolol) is a selective beta blocker that works specifically on the heart. It lowers blood pressure by slowing down the heart and making it work less to pump.Zestril (Lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.
Type of medication
BystolicLisinopril
Antihypertensive
Beta blocker
Prescription only
Antihypertensive
ACE inhibitor
Prescription only
Available as
BystolicLisinopril
  • Pill
  • Pill
Used for (click to learn more)
BystolicLisinopril
Risk factors for serious side effects
BystolicLisinopril
  • Sudden discontinuation of medicine
  • History of asthma
  • History of diabetes
  • Age 65 years or older
  • Using other medicine(s) that slows the heart
Detailed Bystolic (Nebivolol) risks & warnings »
  • Women of childbearing age
    • African descent
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
    Detailed Zestril (Lisinopril) risks & warnings »
    Pregnancy category
    BystolicLisinopril
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Requires routine blood tests to check kidney function.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    BystolicLisinopril
    • Controls your heart rate to reduce work for your heart.
    • A first-line treatment for heart failure and heart attack.
    • Helps to lower blood pressure if you can't use first-choice treatments or need additional blood pressure control.
    • Many beta blockers can worsen asthma or cause headaches, but Bystolic usually doesn't because it targets the heart more specifically and causes fewer side effects.
    • A first-choice blood pressure treatment for many people.
    • Lowers the risk of heart attack and stroke.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
    Downsides and risks
    BystolicLisinopril
    • Not available in less expensive generic form.
    • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
    • Can hide symptoms of low blood sugar if you're diabetic.
    • You can't miss doses. Stopping Bystolic suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
    • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
    • Requires a yearly blood test to see how the medicine is affecting your body.
    • Not safe to use if you're pregnant.
    Tips from our pharmacists for people taking the medication
    BystolicLisinopril
    • Can cause headache, dizziness, or feeling short of breath in the first few days.
    • If side effects don't go away, talk to your doctor about alternatives.
    • Don't stop taking this medicine suddenly.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Can cause dizziness in the first few days.
    • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
    • Requires routine blood tests to check kidney function.
    • Don't take it if you're pregnant.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    Learn more
    More about BystolicSide effectsReviews & ratingsAlternativesFDA package insert
    More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert