Compare Cafergot vs. Zomig

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cafergot
(ergotamine / caffeine)

Zomig
(zolmitriptan)

Treats migraine headaches. Cafergot (ergotamine / caffeine) can treat migraines, but you're more likely to have side effects.Treats migraines. Triptans are the first-choice to treat migraines. Zomig (zolmitriptan) works just as well as other triptans for migraines.
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Coupons for Cafergot
Best available price for 30 (1mg/100mg) tablets of cafergot
Coupons for Zomig
Best available price for 1 (3 tablets of 5mg) dose pack of zomig
Reviews & ratings
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Have you used Cafergot (ergotamine / caffeine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Zomig (zolmitriptan)?
Worth itNot sureNot worth it
Side effects
CafergotZomig

The Cafergot FDA package insert doesn’t have numbers about how common side effects are.

More about Cafergot side effects »
  • Nervous system problems 7%
  • Stomach problems 8%
  • Pain and pressure sensation 7%
  • Unusual sensations 6%
  • Nausea 5%
  • Dizziness 4%
  • Tingling or prickling sensation 5%
  • Neck, throat or jaw pain/pressure 4%
  • Sleepiness 3%
  • Warm or cold sensation 1%
More Zomig side effects »
How it works
CafergotZomig
Cafergot (ergotamine / caffeine) is a combination of ergotamine and caffeine. It tightens the blood vessels in your brain to relieve the pain of your headaches.Zomig (zolmitriptan) is a triptan. It prevents the enlargement of blood vessels in your brain, which causes migraines.
Type of medication
CafergotZomig
Prescription onlyPrescription only
Available as
CafergotZomig
  • Pill
  • Suppository
  • Pill
  • Dissolving tablet
  • Nasal spray
Used for
CafergotZomig
Risk factors for serious side effects
CafergotZomig
  • Overdosing Cafergot (ergotamine / caffeine)
  • Taking triptans (Imitrex, Axert, Maxalt, Amerge, Frova) for migraines
  • Taking Cafergot (ergotamine / caffeine) regularly for months
Detailed Cafergot (ergotamine / caffeine) risks & warnings »
  • Heart disease
  • history of chest pain/angina
  • uncontrolled high blood pressure
  • History of a stroke
  • Using Zomig (zolmitriptan) or other migraine treatment medications for 10 or more days a month
Detailed Zomig (zolmitriptan) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Upsides and benefits
CafergotZomig
  • Cafergot (ergotamine / caffeine) works better than other medicines if your migraines usually last more than 2 days or if you have more frequent migraines.
  • Zomig (zolmitriptan) is is a first choice treatment to treat severe migraines.
  • There are different forms of Zomig (zolmitriptan) available, including a dissolving pill and a nasal spray if you have trouble swallowing during a migraine attack.
  • The regular and dissolving pill forms of Zomig (zolmitriptan) are available as generics.
Downsides and risks
CafergotZomig
  • Cafergot (ergotamine / caffeine) can't stop migraines from happening. They can only treat them.
  • Cafergot (ergotamine / caffeine) can only be used for migraines. It doesn't work for other types of headaches.
  • Smoking or using products that contain nicotine can make Cafergot (ergotamine / caffeine) less effective.
  • If you're taking the nasal spray form of Zomig (zolmitriptan), you have to follow the instructions exactly or you won't get the full dose of medicine.
  • The nasal spray form of Zomig (zolmitriptan) is only available as brand name, so it can be expensive.
  • If you have heart disease or history of stroke, Zomig (zolmitriptan) may not be the best choice for you. Talk to your doctor about your medical history.
Tips from our pharmacists for people taking the medication
CafergotZomig
  • Take Cafergot (ergotamine / caffeine) as soon as you feel the migraine coming on.
  • You might be more sensitive to cold when you take Cafergot (ergotamine / caffeine) since it slows down the circulation of your blood in your skin, fingers and toes. Dress warmly.
  • If you have to take more than 6 tablets or 2 suppositories a day or 10 tablets or 5 suppositories in a week of Cafergot (ergotamine / caffeine), talk to your doctor.
  • Don't smoke tobacco if you're taking Cafergot (ergotamine / caffeine).
  • Keep the suppository of Cafergot (ergotamine / caffeine) in the fridge.
  • Doesn't prevent migraines.
  • Use as soon as you feel a migraine starting. You can take another dose 2 hours later, but don't take more than 10 mg total in 24 hours.
  • Don't use it excessively since it can cause you to have more headaches. Talk to your doctor if you are having more than 4 migraines in a month.
Learn more
More about CafergotSide effectsAlternativesFDA package insert
Have you used Cafergot (ergotamine / caffeine)?
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More about ZomigSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zomig (zolmitriptan)?
Worth itNot sureNot worth it