Compare Calan vs. Hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Calan
(Verapamil)

Microzide
(Hydrochlorothiazide )

Lowers blood pressure and controls heart rate. Verapamil works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding alcohol. You can't miss doses, and you might get persistent swelling.Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
3.761904761904762Calan
Reviews for Calan (Verapamil)
33%
of people say Calan (Verapamil) is worth it
31%
say it works well
21%
say it's a big hassle
Reviews for Microzide (Hydrochlorothiazide (Hctz))
47%
+14% vs. Calan (Verapamil)
31%
Same vs. Calan (Verapamil)
15%
+6% vs. Calan (Verapamil)
Side effects
CalanHydrochlorothiazide

The Calan FDA package insert doesn’t have numbers about how common side effects are.

More about Calan side effects »

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »
How it works
CalanHydrochlorothiazide
Verapamil is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.
Type of medication
CalanHydrochlorothiazide
Antihypertensive
Calcium channel blocker
Prescription only
Antihypertensive
Diuretic
Prescription only
Available as
CalanHydrochlorothiazide
  • Pill
  • Extended release
  • Delayed release capsule
  • Pill
Used for (click to learn more)
CalanHydrochlorothiazide
Risk factors for serious side effects
CalanHydrochlorothiazide
  • Severe left ventricular dysfunction (ejection fraction <30%)
  • Taking beta-blockers
    • History of liver disease
    • History of kidney disease
    • History of liver disease
    Detailed Calan (Verapamil) risks & warnings »
    • Current electrolyte imbalance
    • History of sulfa allergies
    • History of gout
    • Current kidney problems
      Detailed Microzide (Hydrochlorothiazide (Hctz)) risks & warnings »
      Pregnancy category
      CalanHydrochlorothiazide
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      Alcohol
      • Not a good medication for you if you drink alcohol.
      • Don't drink too much alcohol while taking this medicine.
      No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      • Your doctor may monitor your heart to see if changes to its electrical system may occur, especially if you have had liver or kidney disease in the past.
      • Doesn't work well in people with severe kidney problems.
      • Requires routine blood tests to check kidney function.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      CalanHydrochlorothiazide
      • A first-choice blood pressure treatment for many people.
      • Calcium channel blockers work especially well for African Americans to lower blood pressure.
      • You can take it alone or with other medicines to help lower blood pressure.
      • Prevents heart-related chest pain (angina) if you take it regularly.
      • Treats certain abnormal heart rhythms.
      • Lowers the risk of heart attack and stroke.
      • Works well to get rid of extra fluids in your body through urination.
      • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
      • Good option if you have both high blood pressure and heart failure.
      • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
      • Most people have very few side effects.
      • Lowers the risk of heart attack and stroke.
      Downsides and risks
      CalanHydrochlorothiazide
      • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
      • Women are more likely to have side effects (especially swelling) from Verapamil than men.
      • You can't miss doses. Stopping Verapamil suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
      • Not a good medication for you if you drink alcohol.
      • Makes you urinate more often.
      • Doesn't work well in people with severe kidney problems.
      Tips from our pharmacists for people taking the medication
      CalanHydrochlorothiazide
      • Interacts with grapefruit and the cholesterol medicine Simvastatin.
      • Can cause constipation and headache.
      • Don't drink too much alcohol while taking this medicine.
      • Your doctor might do routine blood tests to check your liver function.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Starts working in about 2 hours.
      • Makes you urinate more often, so avoid taking it at bedtime.
      • Can cause dizziness in the first few days.
      • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
      • Requires routine blood tests to check kidney function.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      Learn more
      More about CalanSide effectsReviews & ratingsAlternativesFDA package insert
      More about HydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert