Compare Calan vs. hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Calan
(verapamil)

Microzide
(hydrochlorothiazide )

Lowers blood pressure and controls heart rate. Verapamil works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding alcohol. You can't miss doses, and you might get persistent swelling.Removes water from the body, which lowers blood pressure. Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.84Calan
Reviews for Calan
35%
of people (All ages) say Calan is worth it
33%
say it works well
21%
say it's a big hassle
Have you used Calan (verapamil)?
Worth itNot sureNot worth it
Reviews for hydrochlorothiazide
47%
-12% worse vs. Calan
31%
+2% better vs. Calan
16%
-5% worse vs. Calan
139 reviews
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it
Side effects
Calanhydrochlorothiazide
  • Constipation 7%
  • Dizziness 3%
  • Nausea 3%
  • Hypotension 3%
  • Headache 2%
  • Edema 2%
  • CHF and pulmonary edema 2%
  • Fatigue 2%
  • Lethargy 3%
  • Dyspepsia 3%
More Calan side effects »

The hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about hydrochlorothiazide side effects »
How it works
Calanhydrochlorothiazide
Verapamil is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Microzide (hydrochlorothiazide (HCTZ)) is a thiazide diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, while lowering blood pressure and reducing swelling.
Type of medication
Calanhydrochlorothiazide
Prescription onlyPrescription only
Available as
Calanhydrochlorothiazide
  • Pill
  • Extended release
  • Delayed release capsule
  • Pill
Used for
Calanhydrochlorothiazide
Risk factors for serious side effects
Calanhydrochlorothiazide
  • Severe left ventricular dysfunction (ejection fraction <30%)
  • Taking beta-blockers
  • History of liver disease
  • History of kidney disease
Detailed Calan (verapamil) risks & warnings »
  • Current electrolyte imbalance
  • Lower kidney function
  • Dehydration
  • History of sulfa allergies
  • History of gout
Detailed Microzide (hydrochlorothiazide ) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
Calanhydrochlorothiazide
  • Interacts with grapefruit and the cholesterol medicine Simvastatin.
No interactions related info.
Alcohol
Calanhydrochlorothiazide
  • Don't drink too much alcohol while taking this medicine.
  • Not a good medication for you if you drink alcohol.
No alcohol related info.
Kidneys and liver
Calanhydrochlorothiazide
  • Your doctor may check your liver regularly, as there have been reports of liver damage which can only be seen through blood tests. If you do have a history of liver disease, let your doctor know.
  • Your doctor may monitor your heart to see if changes to its electrical system may occur, especially if you have had liver or kidney disease in the past.
  • Requires routine blood tests to check kidney function.
Upsides and benefits
Calanhydrochlorothiazide
  • A first-choice blood pressure treatment for many people.
  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
  • You can take it alone or with other medicines to help lower blood pressure.
  • Lowers the risk of heart attack and stroke.
  • Prevents heart-related chest pain (angina) if you take it regularly.
  • Treats certain abnormal heart rhythms.
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A first-choice blood pressure treatment. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
Downsides and risks
Calanhydrochlorothiazide
  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
  • Women are more likely to have side effects (especially swelling) from Verapamil than men.
  • You can't miss doses. Stopping Verapamil suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Not a good medication for you if you drink alcohol.
  • Makes you urinate more often.
  • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
  • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
  • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
Tips from our pharmacists for people taking the medication
Calanhydrochlorothiazide
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Interacts with grapefruit and the cholesterol medicine Simvastatin.
  • Can cause constipation and headache.
  • Don't drink too much alcohol while taking this medicine.
  • Your doctor might do routine blood tests to check your liver function.
  • Microzide (hydrochlorothiazide (HCTZ)) starts working in about 2 hours.
  • It makes you urinate more often, so don't take it at bedtime.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any tiredness or muscle weakness that doesn't go away.
  • Requires routine blood tests to check kidney function.
Learn more
More about CalanSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Calan (verapamil)?
Worth itNot sureNot worth it
More about hydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it