Compare Captopril vs. Enalapril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Capoten
(captopril)

Vasotec
(enalapril)

Lowers blood pressure. Captopril is a good blood pressure-lowering medicine that protects kidney function, but you have to take it on an empty stomach.Lowers blood pressure. Enalapril is a good blood pressure-lowering medicine that protects kidney function.
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Coupons for Captopril
Best available price for 60 (25mg) tablets of captopril
Coupons for Enalapril
Best available price for 30 (20mg) tablets of enalapril
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.84Captopril
Reviews for Captopril
34%
of people (All ages) say Captopril is worth it
25%
say it works well
25%
say it's a big hassle
106 reviews
Have you used Capoten (captopril)?
Worth itNot sureNot worth it
Reviews for Enalapril
44%
-10% worse vs. Captopril
40%
-15% worse vs. Captopril
21%
-4% worse vs. Captopril
Have you used Vasotec (enalapril)?
Worth itNot sureNot worth it
Side effects
CaptoprilEnalapril
  • Rash 7%
  • Flushing 5%
  • Abnormal sense of taste 4%
  • Itching 2%
  • Cough 2%
More Captopril side effects »
  • Low blood pressure 7%
  • Positional low blood pressure 2%
  • Muscle weakness 2%
  • Orthostatic effects 2%
  • Fainting 2%
More Enalapril side effects »
How it works
CaptoprilEnalapril
Captopril is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Enalapril is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.
Type of medication
CaptoprilEnalapril
Prescription onlyPrescription only
Available as
CaptoprilEnalapril
  • Pill
  • Pill
  • Liquid
Used for
CaptoprilEnalapril
Risk factors for serious side effects
CaptoprilEnalapril
  • Women of childbearing age
  • African descent
  • Current kidney problems
  • Medicine that increase potassium
  • Use of salt substitute
Detailed Capoten (captopril) risks & warnings »
  • Women of childbearing age
  • African descent
  • Current kidney problems
  • Medicine that increase potassium
  • Use of salt substitute
Detailed Vasotec (enalapril) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
CaptoprilEnalapril
  • Requires routine blood tests to check kidney function.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Requires routine blood tests to check kidney function.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
Upsides and benefits
CaptoprilEnalapril
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • The only ACE inhibitor that doctors can give through an IV if that's needed.
Downsides and risks
CaptoprilEnalapril
  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Compared to other ACE inhibitors, less flexible on when and how you take it. Captopril needs to be taken multiple times a day on an empty stomach.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Compared to other ACE inhibitors, less flexible on when you take it. Enalapril needs to be taken multiple times a day on an empty stomach.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
Tips from our pharmacists for people taking the medication
CaptoprilEnalapril
  • Take 1 hour before or 2 hours after eating.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any dizziness, fatigue, cough, or change in taste sensation that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Don't take it if you're pregnant.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Don't take it if you're pregnant.
Learn more
More about CaptoprilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Capoten (captopril)?
Worth itNot sureNot worth it
More about EnalaprilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vasotec (enalapril)?
Worth itNot sureNot worth it