Compare Captopril vs. Lisinopril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Capoten (Captopril)

Prescription only

Zestril (lisinopril)

Prescription only
Lowers blood pressure.

Captopril is a good blood pressure-lowering medicine that protects kidney function, but you have to take it on an empty stomach.

2.9/ 5 average rating with 106 reviewsforCaptopril
Lowers blood pressure.

Zestril (lisinopril) is a good blood pressure-lowering medicine that protects kidney function.

3.8/ 5 average rating with 687 reviewsforLisinopril
Upsides
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Very cheap drug, and comes available as a liquid for children over 6 years of age.
Downsides
  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Compared to other ACE inhibitors, less flexible on when and how you take it. Captopril needs to be taken multiple times a day on an empty stomach.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
  • Up to 10% of people can get a dry cough while using this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Zestril (lisinopril) isn't safe to use if you're pregnant.
  • Doesn't work as well in people of African descent, and can cause a greater chance of face, tongue, or lip swelling.
Used for
Dosage forms
  • Pill
  • Pill
  • Liquid
Price
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Reviews
106 reviews so far
34%
saidit'sworth it
25%
saiditworked well
25%
saidit'sa big hassle

Have you used Capoten (Captopril)?

Leave a review
687 reviews so far
61%
saidit'sworth it
51%
saiditworked well
14%
saidit'sa big hassle

Have you used Zestril (lisinopril)?

Leave a review
Side effects
5possible side effects
  • Rash
    7%
  • Flushing
    5%
  • Dysgeusia
    4%
  • Pruritus
    2%
  • Cough
    2%
See more detailed side effects
1possible side effects
  • Low blood pressure
    5%
See more detailed side effects
Risks and risk factors
  • Harm to fetus
    • Women of childbearing age
  • Cough
  • Unusual tongue swelling
    • African descent
  • Heart problems due to high potassium
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
See more detailed risks and warnings
  • Harm to fetus
    • Women of childbearing age
  • Cough
  • Swelling of face and head
    • African descent
  • High potassium
    • Current kidney problems
    • Medicines that increase potassium
    • Use of salt substitutes
  • Worsening kidney problems
    • History of kidney problems
  • Low blood pressure
    • Taking with alcohol
    • Taking other medicines that lower your blood pressure
See more detailed risks and warnings
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Disclaimer: We don't provide medical advice. If you think you might have a medical emergency, call your doctor or 911 immediately.