Carafate vs. Omeprazole

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Coming soon.Treats heartburn and stomach ulcers. Prilosec (Omeprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.
How it works
Coming soon.Prilosec (Omeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.
Type of medication
Coming soon.
Acid reducer
Proton pump inhibitor
Prescription or OTC
Available as
  • Pill
  • Liquid
  • Extended release
Used for (click to learn more)
  • Duodenal ulcer disease
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Reviews for Prilosec (Omeprazole)
+80% vs. Carafate (Sucralfate)
+59% vs. Carafate (Sucralfate)
-7% vs. Carafate (Sucralfate)
Side effects

We haven’t found good data for Carafate side effects.

FDA side effect reports for Carafate »

The Omeprazole FDA package insert doesn’t have numbers about how common side effects are.

More about Omeprazole side effects »
Risk factors for serious side effects
Coming soon.
    • Helicobacter pylori infection
    • Autoimmune disease
    • Being hospitalized
    • Antibiotic use
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
      Detailed Prilosec (Omeprazole) risks & warnings »
      Pregnancy category
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      No specific alcohol-related info.No specific alcohol-related info.
      No specific food-related info.
      • Take 1 hour before a meal.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      No specific sex-related info.No specific sex-related info.
      No specific sleep-related info.No specific sleep-related info.
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      Coming soon.
      • Most people can take Omeprazole without any noticeable day-to-day side effects.
      • Omeprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
      • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
      • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
      • Available as both a generic and over-the-counter option, so it's pretty affordable.
      Downsides and risks
      Coming soon.
      • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
      • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
      • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Omeprazole long-term.
      • Although the generic is affordable, other medications might still be cheaper than Omeprazole.
      • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
      Tips from our pharmacists for people taking the medication
      Coming soon.
      • Take 1 hour before a meal.
      • Don't chew or crush capsules; swallow them whole.
      • If you have trouble swallowing you can carefully open the capsules and sprinkle the inside pellets onto applesauce. Swallow the applesauce without chewing or crushing the pellets.
      • When using Omeprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
      • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Omeprazole.
      • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
      Learn more
      More about CarafateSide effectsReviews & ratingsFDA package insert
      More about OmeprazoleSide effectsReviews & ratingsAlternativesFDA package insert