Compare Carafate vs. Omeprazole

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Carafate (Sucralfate)

Prilosec (Omeprazole)

Prescription or OTC
No information currently available
Treats heartburn and stomach ulcers.

Prilosec (Omeprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.

5.5/ 7 average rating with 1167 reviewsforOmeprazole
No information currently available
  • Most people can take Omeprazole without any noticeable day-to-day side effects.
  • Omeprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
No information currently available
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Omeprazole long-term.
  • Although the generic is affordable, other medications might still be cheaper than Omeprazole.
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
Used for
Dosage forms
  • Pill
  • Liquid
  • Extended release
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Side effects
The Carafate (Sucralfate) FDA package insert doesn’t have numbers about how common side effects are.
9possible side effects
  • Upper respiratory infection
  • Fever
  • Headache
  • Abdominal pain
  • Nausea
  • Diarrhea
  • Accidental injuries
  • Vomiting
  • Flatulence
See more detailed side effects
Risks and warnings
No information currently available
  • Severe stomach inflammation (atrophic gastritis)

    Helicobacter pylori infection

    ...and 1 more risk factors

  • Severe diarrhea

    Being hospitalized

    ...and 1 more risk factors

  • Broken bones


    ...and 5 more risk factors

See more detailed risks and warnings