Compare carbidopa / levodopa / entacapone vs. Duopa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Stalevo
(carbidopa / levodopa / entacapone)

Duopa
(carbidopa / levodopa)

Treats Parkinson's disease. Stalevo (carbidopa / levodopa / entacapone) is a good choice for Parkinson's disease, especially when carbidopa/levodopa starts losing its effect.Treats advanced stages of Parkinson's disease. Duopa (carbidopa / levodopa) pumps carbidopa/levodopa into your body throughout the day. It is reserved for advanced Parkinson's disease when your symptoms become more frequent than the dosing of your tablets.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for
Prices and coupon for 120 (150mg) tablets of carbidopa / levodopa / entacapone
Coupons for
Prices and coupon for 90 (25mg/100mg) tablets of carbidopa / levodopa
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Stalevo (carbidopa / levodopa / entacapone)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Duopa (carbidopa / levodopa)?
Worth itNot sureNot worth it
Side effects
carbidopa / levodopa / entacaponeDuopa
  • Difficulty controlling movements 10%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Discolored urine 10%
  • Muscle rigidity 1%
  • Abdominal pain 4%
  • Dizziness 2%
  • Fatigue 2%
  • Constipation 2%
More carbidopa / levodopa / entacapone side effects »
  • Problems with j-tube 56%
  • Nausea 30%
  • Constipation 22%
  • Redness and swelling at the j-tube site 19%
  • Difficulty controlling movements 14%
  • Low mood disorder 11%
  • Discharge at the j-tube site 11%
  • Swelling in the arms and legs 8%
  • High blood pressure 8%
  • Flu and cold 8%
More Duopa side effects »
How it works
carbidopa / levodopa / entacaponeDuopa
Stalevo (carbidopa / levodopa / entacapone) is a combination of carbidopa, levodopa, and entacapone. Entacopone and carbidopa prevent breakdown of levodopa in the body so that levodopa can then enter the brain and relieve symptoms of Parkinson's disease.Duopa (carbidopa / levodopa) is a combination of carbidopa and levodopa. Carbidopa allows levodopa to enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
carbidopa / levodopa / entacaponeDuopa
Prescription only
Prescription only
Available as
carbidopa / levodopa / entacaponeDuopa
  • Pill
  • Liquid
Used for
carbidopa / levodopa / entacaponeDuopa
Risk factors for serious side effects
carbidopa / levodopa / entacaponeDuopa
          • History of stomach ulcers
          Detailed Stalevo (carbidopa / levodopa / entacapone) risks & warnings »
          • Surgery to place the J-tube
          • Taking other medicines for Parkinson's
          • Stopping Duopa (carbidopa / levodopa) suddenly
            • Taking other medicines for Parkinson's disease
            Detailed Duopa (carbidopa / levodopa) risks & warnings »
            Pregnancy

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Pain
            carbidopa / levodopa / entacaponeDuopa
            No pain related info.
            • Call your doctor right away if you start having stomach pains around where the pump is connected.
            Sleep
            carbidopa / levodopa / entacaponeDuopa
            No sleep related info.
            • Duopa (carbidopa / levodopa) can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
            • Duopa (carbidopa / levodopa) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Duopa (carbidopa / levodopa) affects you. You're more at risk if you're taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
            Upsides and benefits
            carbidopa / levodopa / entacaponeDuopa
            • It combines three medicines into one pill so you don't have to take so many pills daily.
            • Stalevo (carbidopa / levodopa / entacapone) is available as a generic.
            • Duopa (carbidopa / levodopa) allows you to have better control of your symptoms than oral tablets, especially in later stages of Parkinson's disease.
            Downsides and risks
            carbidopa / levodopa / entacaponeDuopa
            • You would first start by taking Stalevo (carbidopa / levodopa / entacapone) as two different pills, carbidopa/levodopa and entacapone, before you get switched over to Stalevo (carbidopa / levodopa / entacapone).
            • It's less customizable since there are only a few fixed combinations available.
            • Given via pump so you'll need to have a procedure to attach the pump to your body.
            • You'll need to take good care of the pump so that it doesn't get disconnected or infected.
            • Duopa (carbidopa / levodopa) only lasts for 16 hours. You may need to take an extra dose of carbidopa/levodopa as tablet for nighttime control.
            • You need to keep Duopa (carbidopa / levodopa) in a fridge, but it should sit at room temperature 20 minutes before infusion.
            Tips from our pharmacists for people taking the medication
            carbidopa / levodopa / entacaponeDuopa
            • Stalevo (carbidopa / levodopa / entacapone) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
            • Your saliva, sweat and urine may have dark color and stain your clothing while taking Stalevo (carbidopa / levodopa / entacapone).
            • Take Stalevo (carbidopa / levodopa / entacapone) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
            • Stalevo (carbidopa / levodopa / entacapone) may cause unusual cravings in some people.
            • Duopa (carbidopa / levodopa) is given via pump. You need to have a minor procedure to connect the pump to your body.
            • You may still need to take carbidopa/levodopa in tablet form at night or if the pump disconnects.
            • Call your doctor right away if you start having stomach pains around where the pump is connected.
            • Duopa (carbidopa / levodopa) is only good for 16 hours. Throw out the cassette when the infusion is done even if there's still medicine left inside.
            • Duopa (carbidopa / levodopa) can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
            • Don't stop taking Duopa (carbidopa / levodopa) suddenly. It can be very dangerous. Talk to your doctor if you want to stop taking Duopa (carbidopa / levodopa).
            Learn more
            More about carbidopa / levodopa / entacaponeSide effectsAlternativesFDA package insert
            Have you used Stalevo (carbidopa / levodopa / entacapone)?
            Worth itNot sureNot worth it
            More about DuopaSide effectsAlternativesFDA package insert
            Have you used Duopa (carbidopa / levodopa)?
            Worth itNot sureNot worth it