Compare carbidopa / levodopa / entacapone vs. Rytary

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Stalevo
(carbidopa / levodopa / entacapone)

Rytary
(carbidopa / levodopa)

Treats Parkinson's disease. Stalevo (carbidopa / levodopa / entacapone) is a good choice for Parkinson's disease, especially when carbidopa/levodopa starts losing its effect.Treats Parkinson's disease. Rytary (carbidopa / levodopa) can be used to treat Parkinson's disease, but it can be expensive.
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Prices and coupon for 120 (150mg) tablets of carbidopa / levodopa / entacapone
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Prices and coupon for 90 (25mg/100mg) tablets of carbidopa / levodopa
Reviews & ratings
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Have you used Stalevo (carbidopa / levodopa / entacapone)?
Worth itNot sureNot worth it

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Have you used Rytary (carbidopa / levodopa)?
Worth itNot sureNot worth it
Side effects
carbidopa / levodopa / entacaponeRytary
  • Difficulty controlling movements 10%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Discolored urine 10%
  • Muscle rigidity 1%
  • Abdominal pain 4%
  • Dizziness 2%
  • Fatigue 2%
  • Constipation 2%
More carbidopa / levodopa / entacapone side effects »
  • Nausea 5%
  • Dizziness 4%
  • Dry mouth 2%
  • Abnormal dreams 2%
  • Difficulty controlling movements 2%
  • Anxiety 2%
  • Constipation 1%
More Rytary side effects »
How it works
carbidopa / levodopa / entacaponeRytary
Stalevo (carbidopa / levodopa / entacapone) is a combination of carbidopa, levodopa, and entacapone. Entacopone and carbidopa prevent breakdown of levodopa in the body so that levodopa can then enter the brain and relieve symptoms of Parkinson's disease.Rytary (carbidopa / levodopa) is a combination of carbidopa and levodopa. Levodopa enters the brain and relieves the symptoms of Parkinson's disease. Carbidopa prevents levodopa from being broken down before it can enter the brain.
Type of medication
carbidopa / levodopa / entacaponeRytary
Prescription only
Prescription only
Available as
carbidopa / levodopa / entacaponeRytary
  • Pill
  • Extended release capsule
Used for
carbidopa / levodopa / entacaponeRytary
Risk factors for serious side effects
carbidopa / levodopa / entacaponeRytary
          • History of stomach ulcers
          Detailed Stalevo (carbidopa / levodopa / entacapone) risks & warnings »
          • Taking other medicines for Parkinson's disease
          • Stopping Rytary (carbidopa / levodopa) suddenly
            • Taking other medicines for Parkinson's disease
            • History of heart attack
            • High risk for heart attack
            Detailed Rytary (carbidopa / levodopa) risks & warnings »
            Pregnancy

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Sleep
            carbidopa / levodopa / entacaponeRytary
            No sleep related info.
            • Rytary (carbidopa / levodopa) can make you sleepy or fall asleep suddenly without warning. Don't drive or do anything that requires concentration until you know how Rytary (carbidopa / levodopa) affects you. You're more at risk if you're taking other medicines for Parkinson's disease. Talk to your doctor if this bothers you.
            Upsides and benefits
            carbidopa / levodopa / entacaponeRytary
            • It combines three medicines into one pill so you don't have to take so many pills daily.
            • Stalevo (carbidopa / levodopa / entacapone) is available as a generic.
            • Rytary (carbidopa / levodopa) comes in 4 different strengths.
            • If you have private prescription insurance, there are programs to make Rytary (carbidopa / levodopa) more affordable.
            Downsides and risks
            carbidopa / levodopa / entacaponeRytary
            • You would first start by taking Stalevo (carbidopa / levodopa / entacapone) as two different pills, carbidopa/levodopa and entacapone, before you get switched over to Stalevo (carbidopa / levodopa / entacapone).
            • It's less customizable since there are only a few fixed combinations available.
            • There are other forms of Rytary (carbidopa / levodopa) that are generic and much cheaper.
            • Your doctor might have to change the dose of Rytary (carbidopa / levodopa) often before they find a dose that works for you.
            • Rytary (carbidopa / levodopa) can cause uncontrollable movements to happen, but this doesn't happen for 3 to 5 years.
            • Rytary (carbidopa / levodopa) is not a cure for Parkinson's disease; it can only slow the disease down.
            Tips from our pharmacists for people taking the medication
            carbidopa / levodopa / entacaponeRytary
            • Stalevo (carbidopa / levodopa / entacapone) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
            • Your saliva, sweat and urine may have dark color and stain your clothing while taking Stalevo (carbidopa / levodopa / entacapone).
            • Take Stalevo (carbidopa / levodopa / entacapone) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
            • Stalevo (carbidopa / levodopa / entacapone) may cause unusual cravings in some people.
            • If you can't swallow the capsules whole, they can be sprinkled on 1 to 2 tablespoons of applesauce. You have to take it right away.
            • Don't drive or do anything requiring concentration until you know how Rytary (carbidopa / levodopa) affects you.
            • You can't switch off other forms of carbidopa/levodopa to Rytary (carbidopa / levodopa) without talking to your doctor or pharmacist. They'll tell you how to do it safely.
            Learn more
            More about carbidopa / levodopa / entacaponeSide effectsAlternativesFDA package insert
            Have you used Stalevo (carbidopa / levodopa / entacapone)?
            Worth itNot sureNot worth it
            More about RytarySide effectsAlternativesFDA package insert
            Have you used Rytary (carbidopa / levodopa)?
            Worth itNot sureNot worth it