Compare carbidopa / levodopa extended release vs. carbidopa / levodopa

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Sinemet CR
(carbidopa / levodopa extended release)

Sinemet
(carbidopa / levodopa)

Treats Parkinson's disease. Sinemet CR (carbidopa / levodopa extended release) is the first choice treatment for Parkinson's disease.Treats Parkinson's disease. Sinemet (carbidopa / levodopa) is the first choice treatment for Parkinson's disease.
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Best available price for 90 (50mg/200mg) tablets of carbidopa-levodopa-er
Best available price for 90 (25mg/100mg) tablets of carbidopa-levodopa
Reviews & ratings
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Have you used Sinemet CR (carbidopa / levodopa extended release)?
Worth itNot sureNot worth it

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Have you used Sinemet (carbidopa / levodopa)?
Worth itNot sureNot worth it
Side effects
carbidopa / levodopa extended releasecarbidopa / levodopa
  • Difficulty controlling movements 17%
  • Nausea 6%
  • Hallucinations 4%
  • Confusion 4%
  • Dizziness 3%
  • Low mood disorder 2%
  • Urinary tract infection 2%
  • Back pain 2%
  • Unusual dreams 2%
  • Muscle spasms 2%
More carbidopa / levodopa extended release side effects »

The carbidopa / levodopa FDA package insert doesn’t have numbers about how common side effects are.

More about carbidopa / levodopa side effects »
How it works
carbidopa / levodopa extended releasecarbidopa / levodopa
Sinemet CR (carbidopa / levodopa extended release) is a combination of carbidopa and levodopa that is released in your body over time. Carbidopa prevents breakdown of levodopa so that levodopa can then, enter the brain and relieve symptoms of Parkinson's disease.Sinemet (carbidopa / levodopa) is a combination of carbidopa and levodopa. Carbidopa prevents breakdown of levodopa allowing it to enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
carbidopa / levodopa extended releasecarbidopa / levodopa
Prescription onlyPrescription only
Available as
carbidopa / levodopa extended releasecarbidopa / levodopa
  • Extended release
  • Pill
  • Dissolving tablet
Used for
carbidopa / levodopa extended releasecarbidopa / levodopa
Risk factors for serious side effects
carbidopa / levodopa extended releasecarbidopa / levodopa
  • Taking other medicines for Parkinson's
  • Stopping Sinemet CR (carbidopa / levodopa extended release) suddenly
  • Taking other medicines for Parkinson's disease
Detailed Sinemet CR (carbidopa / levodopa extended release) risks & warnings »
  • Taking other medicines for Parkinson's
  • Stopping Sinemet (carbidopa / levodopa) suddenly
  • Taking other medicines for Parkinson's disease
Detailed Sinemet (carbidopa / levodopa) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Sleep
carbidopa / levodopa extended releasecarbidopa / levodopa
No sleep related info.
  • Can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Can make you very sleepy.
Upsides and benefits
carbidopa / levodopa extended releasecarbidopa / levodopa
  • Sinemet CR (carbidopa / levodopa extended release) is released over a long period of time in your body and can allow you to take fewer pills less frequently.
  • Sinemet (carbidopa / levodopa) is widely available as a regular pill, a quick dissolving pill or a liquid taken through a feeding tube.
  • Sinemet (carbidopa / levodopa) is available in generic.
Downsides and risks
carbidopa / levodopa extended releasecarbidopa / levodopa
  • Sinemet CR (carbidopa / levodopa extended release) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Your saliva, sweat and urine may have dark color and stain your clothing while taking Sinemet CR (carbidopa / levodopa extended release).
  • Sinemet CR (carbidopa / levodopa extended release) will lose its effect over time. If you notice it wearing off sooner than you'd like, talk to your doctor.
  • Sinemet CR (carbidopa / levodopa extended release) may cause unusual cravings in some people.
  • Can make you very sleepy.
  • Can stain your saliva, sweat and urine a dark color.
  • Will lose its effect over time as your disease progresses.
  • May need to be taken several times during day to control symptoms of Parkinson's disease
  • May cause unusual cravings in some people.
Tips from our pharmacists for people taking the medication
carbidopa / levodopa extended releasecarbidopa / levodopa
  • Sinemet CR (carbidopa / levodopa extended release) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Your saliva, sweat and urine may have dark color and stain your clothing while taking Sinemet CR (carbidopa / levodopa extended release).
  • Take Sinemet CR (carbidopa / levodopa extended release) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
  • Sinemet CR (carbidopa / levodopa extended release) may cause unusual cravings in some people.
  • Can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Can stain your saliva, sweat and urine a dark color.
  • Take Sinemet (carbidopa / levodopa) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
  • If you notice Sinemet (carbidopa / levodopa) wearing off sooner than you'd like, talk to your doctor. How much and how often you take it may need to be adjusted.
  • Sinemet (carbidopa / levodopa) may cause unusual cravings in some people.
Learn more
More about carbidopa / levodopa extended releaseSide effectsAlternativesFDA package insert
Have you used Sinemet CR (carbidopa / levodopa extended release)?
Worth itNot sureNot worth it
More about carbidopa / levodopaSide effectsAlternativesFDA package insert
Have you used Sinemet (carbidopa / levodopa)?
Worth itNot sureNot worth it