Compare carbidopa / levodopa extended release vs. Rytary

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats Parkinson's disease.

Sinemet CR (carbidopa / levodopa extended release) is the first choice treatment for Parkinson's disease.

Treats Parkinson's disease.

Rytary (carbidopa / levodopa) can be used to treat Parkinson's disease, but it can be expensive.

Upsides
  • Sinemet CR (carbidopa / levodopa extended release) is released over a long period of time in your body and can allow you to take fewer pills less frequently.
  • Rytary (carbidopa / levodopa) comes in 4 different strengths.
  • If you have private prescription insurance, there are programs to make Rytary (carbidopa / levodopa) more affordable.
Downsides
  • Sinemet CR (carbidopa / levodopa extended release) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Your saliva, sweat and urine may have dark color and stain your clothing while taking Sinemet CR (carbidopa / levodopa extended release).
  • Sinemet CR (carbidopa / levodopa extended release) will lose its effect over time. If you notice it wearing off sooner than you'd like, talk to your doctor.
  • Sinemet CR (carbidopa / levodopa extended release) may cause unusual cravings in some people.
  • There are other forms of Rytary (carbidopa / levodopa) that are generic and much cheaper.
  • Your doctor might have to change the dose of Rytary (carbidopa / levodopa) often before they find a dose that works for you.
  • Rytary (carbidopa / levodopa) can cause uncontrollable movements to happen, but this doesn't happen for 3 to 5 years.
  • Rytary (carbidopa / levodopa) is not a cure for Parkinson's disease; it can only slow the disease down.
Used for
Dosage forms
  • Extended release
  • Extended release capsule
Price
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Reviews
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Side effects
15possible side effects
  • Difficulty controlling movements
    17%
  • Nausea
    6%
  • Hallucinations
    4%
  • Confusion
    4%
  • Dizziness
    3%
  • Depression
    2%
  • Urinary tract infection
    2%
  • Headache
    2%
  • Unusual dreams
    2%
  • Muscle spasms
    2%
  • Vomiting
    2%
  • Upper respiratory infection
    2%
  • Shortness of breath
    2%
  • Periods of immobility
    2%
  • Back pain
    2%
See more detailed side effects
11possible side effects
  • Nausea
    20%
  • Headache
    17%
  • Dizziness
    12%
  • Dry mouth
    7%
  • Trouble sleeping
    6%
  • Abnormal dreams
    5%
  • Difficulty controlling movements
    5%
  • Anxiety
    5%
  • Vomiting
    5%
  • Changes in blood pressure
    5%
  • Constipation
    2%
See more detailed side effects
Risks and risk factors
  • Falling asleep during the day
    • Taking other medicines for Parkinson's
  • High fever and confusion
    • Stopping Sinemet CR (carbidopa / levodopa extended release) suddenly
  • Changes in behavior
  • Lack of impulse control
    • Taking other medicines for Parkinson's disease
  • Changes in blood pressure and falls
See more detailed risks and warnings
  • Falling asleep during the day
    • Taking other medicines for Parkinson's disease
  • High fever and confusion
    • Stopping Rytary (carbidopa / levodopa) suddenly
  • Changes in behavior
  • Lack of impulse control
    • Taking other medicines for Parkinson's disease
  • Heart attack
    • History of heart attack
    • High risk for heart attack
See more detailed risks and warnings