Compare carbidopa / levodopa vs. Azilect

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sinemet (carbidopa / levodopa)

Prescription only

Azilect (rasagiline)

Prescription only
Treats Parkinson's disease.

Sinemet (carbidopa / levodopa) is the first choice treatment for Parkinson's disease.

Treats Parkinson's disease.

Azilect (rasagiline) is one of the recommended medicines to treat Parkinson's disease. It is now available in generic, which makes it more affordable for people without insurance.

Upsides
  • Sinemet (carbidopa / levodopa) is widely available as a regular pill, a quick dissolving pill or a liquid taken through a feeding tube.
  • Sinemet (carbidopa / levodopa) is available in generic.
  • Azilect (rasagiline) is one of the go-to medicines for Parkinson's disease. It can be used in early and late stages of the disease.
  • Taking Azilect (rasagiline) by itself can help slow down Parkinson's disease, but it works better when it's given with other medicines.
  • Azilect (rasagiline) is available as generic as well as brand name, so there are usually lower out-of-pocket costs for you with insurance.
Downsides
  • Can make you very sleepy.
  • Can stain your saliva, sweat and urine a dark color.
  • Will lose its effect over time as your disease progresses.
  • May need to be taken several times during day to control symptoms of Parkinson's disease
  • May cause unusual cravings in some people.
  • It can cause unusual cravings and changes in behavior in some people.
Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Pill
Price
Lowest price near you
$18.44
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Lowest price near you
$195.29
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Side effects
The Sinemet (carbidopa / levodopa) FDA package insert doesn’t have numbers about how common side effects are.
9possible side effects
  • Difficulty controlling movement
    18%
  • Headache
    14%
  • Accidental injury
    12%
  • Nausea
    12%
  • Falls
    11%
  • Weight loss
    9%
  • Constipation
    9%
  • Low blood pressure
    9%
  • Joint pain
    8%
See more detailed side effects
Risks and warnings
  • Falling asleep during the day

    Taking other medicines for Parkinson's

  • High fever and confusion

    Stopping Sinemet (carbidopa / levodopa) suddenly

  • Lack of impulse control

    Taking other medicines for Parkinson's disease

See more detailed risks and warnings
  • Increased blood pressure

    Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats

  • Serotonin syndrome

    Tricyclic antidepressants

    ...and 7 more risk factors

  • Falling asleep during the day

    Taking other medicines for Parkinson's disease

  • Movement problems

    Taking other medicines for Parkinson's disease

  • Lack of impulse control

    Taking other medicines for Parkinson's disease

See more detailed risks and warnings