Compare carbidopa / levodopa vs. Azilect

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sinemet
(carbidopa / levodopa)

Azilect
(rasagiline)

Treats Parkinson's disease. Sinemet (carbidopa / levodopa) is the first choice treatment for Parkinson's disease.Treats Parkinson's disease. Azilect (rasagiline) is one of the recommended medicines to treat Parkinson's disease. It is now available in generic, which makes it more affordable for people without insurance.
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Prices and coupon for 90 (25mg/100mg) tablets of carbidopa / levodopa
Coupons for
Prices and coupon for 30 (1mg) tablets of rasagiline
Reviews & ratings
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Have you used Sinemet (carbidopa / levodopa)?
Worth itNot sureNot worth it

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Have you used Azilect (rasagiline)?
Worth itNot sureNot worth it
Side effects
carbidopa / levodopaAzilect

The carbidopa / levodopa FDA package insert doesn’t have numbers about how common side effects are.

More about carbidopa / levodopa side effects »
  • Difficulty controlling movement 8%
  • Headache 2%
  • Accidental injury 7%
  • Nausea 4%
  • Falls 3%
  • Low blood pressure 6%
  • Constipation 4%
  • Weight loss 6%
  • Joint pain 4%
  • Diarrhea 3%
More Azilect side effects »
How it works
carbidopa / levodopaAzilect
Sinemet (carbidopa / levodopa) is a combination of carbidopa and levodopa. Carbidopa prevents breakdown of levodopa allowing it to enter the brain and relieve symptoms of Parkinson's disease.Azilect (rasagiline) is a monoamine oxidase inhibitor. It increases the amount of dopamine in the brain, which helps those with Parkinson's disease gain better control their movements.
Type of medication
carbidopa / levodopaAzilect
Prescription only
Prescription only
Available as
carbidopa / levodopaAzilect
  • Pill
  • Dissolving tablet
  • Pill
Used for
carbidopa / levodopaAzilect
Risk factors for serious side effects
carbidopa / levodopaAzilect
  • Taking other medicines for Parkinson's
  • Stopping Sinemet (carbidopa / levodopa) suddenly
    • Taking other medicines for Parkinson's disease
      Detailed Sinemet (carbidopa / levodopa) risks & warnings »
      • Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats
      • Tricyclic antidepressants
      • Fentanyl
      • Tramadol
      • Buspirone
      • ADHD medicines
      • Triptans
      • dextromethorphan
      • pseudoephedrine
      • Taking other medicines for Parkinson's disease
        • Taking other medicines for Parkinson's disease
        • Taking other medicines for Parkinson's disease
        Detailed Azilect (rasagiline) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Sleep
        carbidopa / levodopaAzilect
        • Can make you very sleepy.
        • Can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
        No sleep related info.
        Upsides and benefits
        carbidopa / levodopaAzilect
        • Sinemet (carbidopa / levodopa) is widely available as a regular pill, a quick dissolving pill or a liquid taken through a feeding tube.
        • Sinemet (carbidopa / levodopa) is available in generic.
        • Azilect (rasagiline) is one of the go-to medicines for Parkinson's disease. It can be used in early and late stages of the disease.
        • Taking Azilect (rasagiline) by itself can help slow down Parkinson's disease, but it works better when it's given with other medicines.
        • Azilect (rasagiline) is available as generic as well as brand name, so there are usually lower out-of-pocket costs for you with insurance.
        Downsides and risks
        carbidopa / levodopaAzilect
        • Can make you very sleepy.
        • Can stain your saliva, sweat and urine a dark color.
        • Will lose its effect over time as your disease progresses.
        • May need to be taken several times during day to control symptoms of Parkinson's disease
        • May cause unusual cravings in some people.
        • It can cause unusual cravings and changes in behavior in some people.
        Tips from our pharmacists for people taking the medication
        carbidopa / levodopaAzilect
        • Can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
        • Can stain your saliva, sweat and urine a dark color.
        • Take Sinemet (carbidopa / levodopa) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
        • If you notice Sinemet (carbidopa / levodopa) wearing off sooner than you'd like, talk to your doctor. How much and how often you take it may need to be adjusted.
        • Sinemet (carbidopa / levodopa) may cause unusual cravings in some people.
        • Azilect (rasagiline) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
        • Watch how much cheese, soy sauce or smoked meats you eat. Eating too much of these foods while on Azilect (rasagiline) can cause an unsafe rise in blood pressure.
        • Azilect (rasagiline) can make you dizzy or lightheaded, especially when you suddenly stand up from sitting or laying down.
        • Don't stop taking Azilect (rasagiline) without talking to your doctor first. Stopping it suddenly can cause confusion, stiff muscles and a high fever.
        • Azilect (rasagiline) can prevent many medicines from working properly. Check with your doctor or pharmacist if the way you take your other medicines needs to be changed.
        Learn more
        More about carbidopa / levodopaSide effectsAlternativesFDA package insert
        Have you used Sinemet (carbidopa / levodopa)?
        Worth itNot sureNot worth it
        More about AzilectSide effectsAlternativesFDA package insert
        Have you used Azilect (rasagiline)?
        Worth itNot sureNot worth it