Compare carbidopa / levodopa vs. carbidopa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sinemet
(carbidopa / levodopa)

Lodosyn
(carbidopa)

Treats Parkinson's disease. Sinemet (carbidopa / levodopa) is the first choice treatment for Parkinson's disease.Treats Parkinson's disease when given with levodopa. Lodosyn (carbidopa) enhances the effect of levodopa. It cannot relieve symptoms of Parkinson's disease when taken by itself.
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Prices and coupon for 90 (25mg/100mg) tablets of carbidopa / levodopa
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Prices and coupon for 90 (25mg) tablets of carbidopa
Reviews & ratings
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Have you used Sinemet (carbidopa / levodopa)?
Worth itNot sureNot worth it

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Have you used Lodosyn (carbidopa)?
Worth itNot sureNot worth it
Side effects
carbidopa / levodopacarbidopa

The carbidopa / levodopa FDA package insert doesn’t have numbers about how common side effects are.

More about carbidopa / levodopa side effects »

We haven’t found good data for carbidopa side effects.

FDA side effect reports for carbidopa »
How it works
carbidopa / levodopacarbidopa
Sinemet (carbidopa / levodopa) is a combination of carbidopa and levodopa. Carbidopa prevents breakdown of levodopa allowing it to enter the brain and relieve symptoms of Parkinson's disease.Lodosyn (carbidopa) is a decarboxylase inhibitor that allows levodopa to enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
carbidopa / levodopacarbidopa
Prescription only
Prescription only
Available as
carbidopa / levodopacarbidopa
  • Pill
  • Dissolving tablet
  • Pill
Used for
carbidopa / levodopacarbidopa
Risk factors for serious side effects
carbidopa / levodopacarbidopa
  • Taking other medicines for Parkinson's
  • Stopping Sinemet (carbidopa / levodopa) suddenly
    • Taking other medicines for Parkinson's disease
      Detailed Sinemet (carbidopa / levodopa) risks & warnings »
        Detailed Lodosyn (carbidopa) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Sleep
        carbidopa / levodopacarbidopa
        • Can make you very sleepy.
        • Can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
        No sleep related info.
        Upsides and benefits
        carbidopa / levodopacarbidopa
        • Sinemet (carbidopa / levodopa) is widely available as a regular pill, a quick dissolving pill or a liquid taken through a feeding tube.
        • Sinemet (carbidopa / levodopa) is available in generic.
        • Extra doses of Lodosyn (carbidopa) allows you to get more out of levodopa, especially in later stages of the disease.
        • It is available in a combination pill with levodopa once you find the right dose that works for you.
        Downsides and risks
        carbidopa / levodopacarbidopa
        • Can make you very sleepy.
        • Can stain your saliva, sweat and urine a dark color.
        • Will lose its effect over time as your disease progresses.
        • May need to be taken several times during day to control symptoms of Parkinson's disease
        • May cause unusual cravings in some people.
        • Your doctor may need to change the dose of Lodosyn (carbidopa) frequently before finding the right dose.
        Tips from our pharmacists for people taking the medication
        carbidopa / levodopacarbidopa
        • Can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
        • Can stain your saliva, sweat and urine a dark color.
        • Take Sinemet (carbidopa / levodopa) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
        • If you notice Sinemet (carbidopa / levodopa) wearing off sooner than you'd like, talk to your doctor. How much and how often you take it may need to be adjusted.
        • Sinemet (carbidopa / levodopa) may cause unusual cravings in some people.
        • Lodosyn (carbidopa) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
        • Your saliva, sweat and urine may have dark color and stain your clothing while taking Lodosyn (carbidopa).
        • Take Lodosyn (carbidopa) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
        • Lodosyn (carbidopa) doesn't work when taken by itself. Don't stop taking your other medicines for Parkinson's disease.
        • Lodosyn (carbidopa) may cause unusual cravings in some people.
        Learn more
        More about carbidopa / levodopaSide effectsAlternativesFDA package insert
        Have you used Sinemet (carbidopa / levodopa)?
        Worth itNot sureNot worth it
        More about carbidopaSide effectsAlternativesFDA package insert
        Have you used Lodosyn (carbidopa)?
        Worth itNot sureNot worth it