Compare carbidopa / levodopa vs. carbidopa / levodopa / entacapone
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Sinemet (carbidopa / levodopa) is the first choice treatment for Parkinson's disease.
Stalevo (carbidopa / levodopa / entacapone) is a good choice for Parkinson's disease, especially when carbidopa/levodopa starts losing its effect.
- Sinemet (carbidopa / levodopa) is widely available as a regular pill, a quick dissolving pill or a liquid taken through a feeding tube.
- Sinemet (carbidopa / levodopa) is available in generic.
- It combines three medicines into one pill so you don't have to take so many pills daily.
- Stalevo (carbidopa / levodopa / entacapone) is available as a generic.
- Can make you very sleepy.
- Can stain your saliva, sweat and urine a dark color.
- Will lose its effect over time as your disease progresses.
- May need to be taken several times during day to control symptoms of Parkinson's disease
- May cause unusual cravings in some people.
- You would first start by taking Stalevo (carbidopa / levodopa / entacapone) as two different pills, carbidopa/levodopa and entacapone, before you get switched over to Stalevo (carbidopa / levodopa / entacapone).
- It's less customizable since there are only a few fixed combinations available.
- Dissolving tablet
- Difficulty controlling movements25%
- Muscle spasm10%
- Changes in urine color10%
- Discolored urine10%
- Muscle rigidity9%
- Abdominal pain8%
- Falling asleep during the day
Taking other medicines for Parkinson's
- High fever and confusion
Stopping Sinemet (carbidopa / levodopa) suddenly
- Lack of impulse control
Taking other medicines for Parkinson's disease
- Stomach bleeding
History of stomach ulcers