Compare carbidopa / levodopa vs. Eldepryl

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sinemet
(carbidopa / levodopa)

Eldepryl
(selegiline)

Treats Parkinson's disease. Sinemet (carbidopa / levodopa) is the first choice treatment for Parkinson's disease.Treats Parkinson's disease. Used with other medicines for Parkinson's disease to boost its effect.
Reviews & ratings
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Have you used Sinemet (carbidopa / levodopa)?
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Have you used Eldepryl (selegiline)?
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Side effects
carbidopa / levodopaEldepryl

The carbidopa / levodopa FDA package insert doesn’t have numbers about how common side effects are.

More about carbidopa / levodopa side effects »
  • Skin irritation at the patch 12%
  • Headache 1%
  • Insomnia 5%
  • Diarrhea 2%
  • Dry mouth 2%
  • Weight loss of at least 5% 2%
  • Indigestion 1%
  • Rash 2%
  • Sinus infection 2%
  • Sore throat 1%
More Eldepryl side effects »
How it works
carbidopa / levodopaEldepryl
Sinemet (carbidopa / levodopa) is a combination of carbidopa and levodopa. Carbidopa prevents breakdown of levodopa allowing it to enter the brain and relieve symptoms of Parkinson's disease.Eldepryl (selegiline) is a selective monoamine oxidase inhibitor. It regulates the amount of dopamine in your body.
Type of medication
carbidopa / levodopaEldepryl
Prescription onlyPrescription only
Available as
carbidopa / levodopaEldepryl
  • Pill
  • Dissolving tablet
  • Pill
  • Dissolving tablet
Used for
carbidopa / levodopaEldepryl
Risk factors for serious side effects
carbidopa / levodopaEldepryl
  • Taking other medicines for Parkinson's
  • Stopping Sinemet (carbidopa / levodopa) suddenly
  • Taking other medicines for Parkinson's disease
Detailed Sinemet (carbidopa / levodopa) risks & warnings »
  • Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats
  • Taking cough and cold medicines like dextromethorphan (Robitussin DM), pseudoephedrine (Sudafed)
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
Detailed Eldepryl (selegiline) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
carbidopa / levodopaEldepryl
No food related info.
  • Avoid eating foods high in tyramine while taking Eldepryl (selegiline), since it can increase your blood pressure.
Sleep
carbidopa / levodopaEldepryl
  • Can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Can make you very sleepy.
No sleep related info.
Upsides and benefits
carbidopa / levodopaEldepryl
  • Sinemet (carbidopa / levodopa) is widely available as a regular pill, a quick dissolving pill or a liquid taken through a feeding tube.
  • Sinemet (carbidopa / levodopa) is available in generic.
  • There are two different versions of Eldepryl (selegiline), a quick dissolving tablet and a regular tablet.
  • Eldepryl (selegiline) is one of the recommended medicines you can take along with carbidopa/levodopa if your Parkinson's disease is getting worse.
Downsides and risks
carbidopa / levodopaEldepryl
  • Can make you very sleepy.
  • Can stain your saliva, sweat and urine a dark color.
  • Will lose its effect over time as your disease progresses.
  • May need to be taken several times during day to control symptoms of Parkinson's disease
  • May cause unusual cravings in some people.
  • You may have to limit the amount of cheese, smoked meat, and soy sauce you eat while taking Eldepryl (selegiline) since it can raise your blood pressure.
  • Can keep you up at night if you take it later in the day
  • Doesn't work by itself to treat Parkinson's disease.
Tips from our pharmacists for people taking the medication
carbidopa / levodopaEldepryl
  • Can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Can stain your saliva, sweat and urine a dark color.
  • Take Sinemet (carbidopa / levodopa) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
  • If you notice Sinemet (carbidopa / levodopa) wearing off sooner than you'd like, talk to your doctor. How much and how often you take it may need to be adjusted.
  • Sinemet (carbidopa / levodopa) may cause unusual cravings in some people.
  • Watch how much smoked meat, cheese, pickles and soy sauce you eat while taking Eldepryl (selegiline) since it can raise your blood pressure.
  • Avoid taking your doses later in the day because it can keep you up.
  • Don't stop Eldepryl (selegiline) suddenly without talking to your doctor, since it can be dangerous.
Learn more
More about carbidopa / levodopaSide effectsAlternativesFDA package insert
Have you used Sinemet (carbidopa / levodopa)?
Worth itNot sureNot worth it
More about EldeprylSide effectsAlternativesFDA package insert
Have you used Eldepryl (selegiline)?
Worth itNot sureNot worth it