Compare carbidopa / levodopa vs. entacapone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sinemet
(carbidopa / levodopa)

Comtan
(entacapone)

Treats Parkinson's disease. Sinemet (carbidopa / levodopa) is the first choice treatment for Parkinson's disease.Treats Parkinson's disease. Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.
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Best available price for 90 (25mg/100mg) tablets of carbidopa / levodopa
Coupons for entacapone
Best available price for 90 (200mg) tablets of entacapone
Reviews & ratings
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Reviews for Sinemet (carbidopa / levodopa)
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of people (All ages) say Sinemet (carbidopa / levodopa) is worth it
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say it works well
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say it's a big hassle
Have you used Sinemet (carbidopa / levodopa)?
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Reviews for Comtan (entacapone)
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Same vs. Sinemet (carbidopa / levodopa)
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Same vs. Sinemet (carbidopa / levodopa)
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Same vs. Sinemet (carbidopa / levodopa)
Have you used Comtan (entacapone)?
Worth itNot sureNot worth it
Side effects
carbidopa / levodopaentacapone

The carbidopa / levodopa FDA package insert doesn’t have numbers about how common side effects are.

More about carbidopa / levodopa side effects »
  • Difficulty controlling movements 10%
  • Nausea 6%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Diarrhea 6%
  • Muscle rigidity 1%
  • Dizziness 2%
  • Abdominal pain 4%
  • Fatigue 2%
  • Constipation 2%
More entacapone side effects »
How it works
carbidopa / levodopaentacapone
Sinemet (carbidopa / levodopa) is a combination of carbidopa and levodopa. Carbidopa prevents breakdown of levodopa allowing it to enter the brain and relieve symptoms of Parkinson's disease.Comtan (entacapone) is a COMT inhibitor. It prevents levodopa from breaking down before it enters the brain.
Type of medication
carbidopa / levodopaentacapone
Prescription only
Prescription only
Available as
carbidopa / levodopaentacapone
  • Pill
  • Dissolving tablet
  • Pill
Used for
carbidopa / levodopaentacapone
Risk factors for serious side effects
carbidopa / levodopaentacapone
  • Taking other medicines for Parkinson's
  • Stopping Sinemet (carbidopa / levodopa) suddenly
  • Taking other medicines for Parkinson's disease
Detailed Sinemet (carbidopa / levodopa) risks & warnings »
  • Taking other medicines for Parkinson's
  • Low blood pressure
  • Taking medicines for high blood pressure
  • Taking other medicines for Parkinson's disease
Detailed Comtan (entacapone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Sleep
carbidopa / levodopaentacapone
  • Can make you very sleepy.
  • Can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Can make you very sleepy
  • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • Comtan (entacapone) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Comtan (entacapone) affects you. This is more likely if you're also taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
Upsides and benefits
carbidopa / levodopaentacapone
  • Sinemet (carbidopa / levodopa) is widely available as a regular pill, a quick dissolving pill or a liquid taken through a feeding tube.
  • Sinemet (carbidopa / levodopa) is available in generic.
  • Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
  • Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.
Downsides and risks
carbidopa / levodopaentacapone
  • Can make you very sleepy.
  • Can stain your saliva, sweat and urine a dark color.
  • Will lose its effect over time as your disease progresses.
  • May need to be taken several times during day to control symptoms of Parkinson's disease
  • May cause unusual cravings in some people.
  • Must be taken with other medicines for Parkinson's disease
  • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
  • Can make you very sleepy
  • May require frequent adjustments before finding the dose that works best for you
Tips from our pharmacists for people taking the medication
carbidopa / levodopaentacapone
  • Can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Can stain your saliva, sweat and urine a dark color.
  • Take Sinemet (carbidopa / levodopa) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
  • If you notice Sinemet (carbidopa / levodopa) wearing off sooner than you'd like, talk to your doctor. How much and how often you take it may need to be adjusted.
  • Sinemet (carbidopa / levodopa) may cause unusual cravings in some people.
  • Doesn't work by itself. Must be taken with other medicines for Parkinson's disease
  • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
  • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • May cause an upset stomach
  • May require frequent adjusting until you the dose that works best
Learn more
More about carbidopa / levodopaSide effectsAlternativesFDA package insert
Have you used Sinemet (carbidopa / levodopa)?
Worth itNot sureNot worth it
More about entacaponeSide effectsAlternativesFDA package insert
Have you used Comtan (entacapone)?
Worth itNot sureNot worth it