Compare carbidopa / levodopa vs. Mirapex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sinemet (carbidopa / levodopa)

Prescription only

Mirapex (Pramipexole)

Prescription only
Treats Parkinson's disease.

Sinemet (carbidopa / levodopa) is the first choice treatment for Parkinson's disease.

Helps with movement problems.

Mirapex (Pramipexole) is an effective medicine for Parkinson's disease or restless leg syndrome, but there are potentially serious side effects.

  • Sinemet (carbidopa / levodopa) is widely available as a regular pill, a quick dissolving pill or a liquid taken through a feeding tube.
  • Sinemet (carbidopa / levodopa) is available in generic.
  • In studies, Mirapex (Pramipexole) when taken by itself or with other medicines, was effective in lowering movement fluctuations for people with Parkinson's disease.
  • Mirapex (Pramipexole) is sometimes preferred over other medicines that treat Parkinson's disease in older people since it causes fewer movement and mental fluctuations.
  • Is effective for treating restless leg syndrome.
  • Available in a short-acting and a long-acting form.
  • Can make you very sleepy.
  • Can stain your saliva, sweat and urine a dark color.
  • Will lose its effect over time as your disease progresses.
  • May need to be taken several times during day to control symptoms of Parkinson's disease
  • May cause unusual cravings in some people.
  • Mirapex (Pramipexole) isn't a first-choice treatment for Parkinson's disease. It can be used by itself, but it's usually used with other medicines.
  • Mirapex (Pramipexole) can cause hallucinations in older people.
  • Not the best choice if you have kidney problems. Your doctor may have to adjust your dose based on your kidney function.
  • You can't suddenly stop taking Mirapex (Pramipexole). You'll have to slowly lower your dose, especially if you've been using it for a long time.
Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Pill
  • Extended release
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Side effects
The Sinemet (carbidopa / levodopa) FDA package insert doesn’t have numbers about how common side effects are.
8possible side effects
  • Postural hypotension
  • Dyskinesia
  • Extrapyramidal syndrome
  • Insomnia
  • Dizziness
  • Accidental injury
  • Hallucinations
  • Any side effect
See more detailed side effects
Risks and warnings
  • Falling asleep during the day

    Taking other medicines for Parkinson's

  • High fever and confusion

    Stopping Sinemet (carbidopa / levodopa) suddenly

  • Lack of impulse control

    Taking other medicines for Parkinson's disease

See more detailed risks and warnings
  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Low blood pressure

    Taking blood pressure-lowering medicines

  • Worsening kidney function

    Current kidney problems

  • Skin cancer

    Parkinson's disease

  • Hallucinations

    Age 65 years or older

See more detailed risks and warnings