Compare carbidopa / levodopa vs. Rytary

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sinemet (carbidopa / levodopa)

Prescription only
Treats Parkinson's disease.

Sinemet (carbidopa / levodopa) is the first choice treatment for Parkinson's disease.

Treats Parkinson's disease.

Rytary (carbidopa / levodopa) can be used to treat Parkinson's disease, but it can be expensive.

Upsides
  • Sinemet (carbidopa / levodopa) is widely available as a regular pill, a quick dissolving pill or a liquid taken through a feeding tube.
  • Sinemet (carbidopa / levodopa) is available in generic.
  • Rytary (carbidopa / levodopa) comes in 4 different strengths.
  • If you have private prescription insurance, there are programs to make Rytary (carbidopa / levodopa) more affordable.
Downsides
  • Can make you very sleepy.
  • Can stain your saliva, sweat and urine a dark color.
  • Will lose its effect over time as your disease progresses.
  • May need to be taken several times during day to control symptoms of Parkinson's disease
  • May cause unusual cravings in some people.
  • There are other forms of Rytary (carbidopa / levodopa) that are generic and much cheaper.
  • Your doctor might have to change the dose of Rytary (carbidopa / levodopa) often before they find a dose that works for you.
  • Rytary (carbidopa / levodopa) can cause uncontrollable movements to happen, but this doesn't happen for 3 to 5 years.
  • Rytary (carbidopa / levodopa) is not a cure for Parkinson's disease; it can only slow the disease down.
Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Extended release capsule
Price
Lowest price near you
$18.44
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Lowest price near you
$18.44
Find instant savings
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Side effects
The Sinemet (carbidopa / levodopa) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Nausea
    20%
  • Headache
    17%
  • Dizziness
    12%
  • Dry mouth
    7%
  • Trouble sleeping
    6%
  • Abnormal dreams
    5%
  • Difficulty controlling movements
    5%
  • Anxiety
    5%
  • Vomiting
    5%
  • Changes in blood pressure
    5%
See more detailed side effects
Risks and warnings
  • Falling asleep during the day

    Taking other medicines for Parkinson's

  • High fever and confusion

    Stopping Sinemet (carbidopa / levodopa) suddenly

  • Lack of impulse control

    Taking other medicines for Parkinson's disease

See more detailed risks and warnings
  • Falling asleep during the day

    Taking other medicines for Parkinson's disease

  • High fever and confusion

    Stopping Rytary (carbidopa / levodopa) suddenly

  • Lack of impulse control

    Taking other medicines for Parkinson's disease

  • Heart attack

    History of heart attack

    ...and 1 more risk factors

See more detailed risks and warnings