Compare carbidopa / levodopa vs. Rytary

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sinemet
(carbidopa / levodopa)

Rytary
(carbidopa / levodopa)

Treats Parkinson's disease. Sinemet (carbidopa / levodopa) is the first choice treatment for Parkinson's disease.Treats Parkinson's disease. Rytary (carbidopa / levodopa) can be used to treat Parkinson's disease, but it can be expensive.
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Prices and coupon for 90 (25mg/100mg) tablets of carbidopa / levodopa
Coupons for
Prices and coupon for 90 (25mg/100mg) tablets of carbidopa / levodopa
Reviews & ratings
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Have you used Sinemet (carbidopa / levodopa)?
Worth itNot sureNot worth it

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Have you used Rytary (carbidopa / levodopa)?
Worth itNot sureNot worth it
Side effects
carbidopa / levodopaRytary

The carbidopa / levodopa FDA package insert doesn’t have numbers about how common side effects are.

More about carbidopa / levodopa side effects »
  • Nausea 5%
  • Dizziness 4%
  • Dry mouth 2%
  • Abnormal dreams 2%
  • Difficulty controlling movements 2%
  • Anxiety 2%
  • Constipation 1%
More Rytary side effects »
How it works
carbidopa / levodopaRytary
Sinemet (carbidopa / levodopa) is a combination of carbidopa and levodopa. Carbidopa prevents breakdown of levodopa allowing it to enter the brain and relieve symptoms of Parkinson's disease.Rytary (carbidopa / levodopa) is a combination of carbidopa and levodopa. Levodopa enters the brain and relieves the symptoms of Parkinson's disease. Carbidopa prevents levodopa from being broken down before it can enter the brain.
Type of medication
carbidopa / levodopaRytary
Prescription only
Prescription only
Available as
carbidopa / levodopaRytary
  • Pill
  • Dissolving tablet
  • Extended release capsule
Used for
carbidopa / levodopaRytary
Risk factors for serious side effects
carbidopa / levodopaRytary
  • Taking other medicines for Parkinson's
  • Stopping Sinemet (carbidopa / levodopa) suddenly
    • Taking other medicines for Parkinson's disease
      Detailed Sinemet (carbidopa / levodopa) risks & warnings »
      • Taking other medicines for Parkinson's disease
      • Stopping Rytary (carbidopa / levodopa) suddenly
        • Taking other medicines for Parkinson's disease
        • History of heart attack
        • High risk for heart attack
        Detailed Rytary (carbidopa / levodopa) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Sleep
        carbidopa / levodopaRytary
        • Can make you very sleepy.
        • Can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
        • Rytary (carbidopa / levodopa) can make you sleepy or fall asleep suddenly without warning. Don't drive or do anything that requires concentration until you know how Rytary (carbidopa / levodopa) affects you. You're more at risk if you're taking other medicines for Parkinson's disease. Talk to your doctor if this bothers you.
        Upsides and benefits
        carbidopa / levodopaRytary
        • Sinemet (carbidopa / levodopa) is widely available as a regular pill, a quick dissolving pill or a liquid taken through a feeding tube.
        • Sinemet (carbidopa / levodopa) is available in generic.
        • Rytary (carbidopa / levodopa) comes in 4 different strengths.
        • If you have private prescription insurance, there are programs to make Rytary (carbidopa / levodopa) more affordable.
        Downsides and risks
        carbidopa / levodopaRytary
        • Can make you very sleepy.
        • Can stain your saliva, sweat and urine a dark color.
        • Will lose its effect over time as your disease progresses.
        • May need to be taken several times during day to control symptoms of Parkinson's disease
        • May cause unusual cravings in some people.
        • There are other forms of Rytary (carbidopa / levodopa) that are generic and much cheaper.
        • Your doctor might have to change the dose of Rytary (carbidopa / levodopa) often before they find a dose that works for you.
        • Rytary (carbidopa / levodopa) can cause uncontrollable movements to happen, but this doesn't happen for 3 to 5 years.
        • Rytary (carbidopa / levodopa) is not a cure for Parkinson's disease; it can only slow the disease down.
        Tips from our pharmacists for people taking the medication
        carbidopa / levodopaRytary
        • Can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
        • Can stain your saliva, sweat and urine a dark color.
        • Take Sinemet (carbidopa / levodopa) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
        • If you notice Sinemet (carbidopa / levodopa) wearing off sooner than you'd like, talk to your doctor. How much and how often you take it may need to be adjusted.
        • Sinemet (carbidopa / levodopa) may cause unusual cravings in some people.
        • If you can't swallow the capsules whole, they can be sprinkled on 1 to 2 tablespoons of applesauce. You have to take it right away.
        • Don't drive or do anything requiring concentration until you know how Rytary (carbidopa / levodopa) affects you.
        • You can't switch off other forms of carbidopa/levodopa to Rytary (carbidopa / levodopa) without talking to your doctor or pharmacist. They'll tell you how to do it safely.
        Learn more
        More about carbidopa / levodopaSide effectsAlternativesFDA package insert
        Have you used Sinemet (carbidopa / levodopa)?
        Worth itNot sureNot worth it
        More about RytarySide effectsAlternativesFDA package insert
        Have you used Rytary (carbidopa / levodopa)?
        Worth itNot sureNot worth it