Compare carbidopa / levodopa vs. Symmetrel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sinemet (carbidopa / levodopa)

Prescription only

Symmetrel (amantadine)

Prescription only
Treats Parkinson's disease.

Sinemet (carbidopa / levodopa) is the first choice treatment for Parkinson's disease.

Treats Parkinson's disease, the flu, and side effects from antipsychotic drugs.

Symmetrel (amantadine) is a generic medicine that can be used alone, or with other medicines to treat early Parkinson's disease.

Upsides
  • Sinemet (carbidopa / levodopa) is widely available as a regular pill, a quick dissolving pill or a liquid taken through a feeding tube.
  • Sinemet (carbidopa / levodopa) is available in generic.
  • Symmetrel (amantadine) can be taken by itself or with other medicines to treat the symptoms of early Parkinson's disease, including muscle spasms, tremors, and difficulty with movements.
  • Symmetrel (amantadine) is available in generic and in both a pill and liquid form.
  • Compared to other medicines for Parkinson's disease, the side effects are relatively mild.
Downsides
  • Can make you very sleepy.
  • Can stain your saliva, sweat and urine a dark color.
  • Will lose its effect over time as your disease progresses.
  • May need to be taken several times during day to control symptoms of Parkinson's disease
  • May cause unusual cravings in some people.
  • Symmetrel (amantadine) sometimes has to be taken multiple times a day.
  • Symmetrel (amantadine) can’t stop or cure Parkinson's disease. It can only slow down the progression.
  • You can't take certain forms of the flu vaccine if you're taking Symmetrel (amantadine). Talk to your doctor before receiving vaccines.
  • You can't stop taking Symmetrel (amantadine) suddenly without talking to your doctor since your Parkinson's can get worse.
Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Pill
  • Liquid
Price
Lowest price near you
$18.44
Find instant savings
Lowest price near you
$38.3
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
Not enough review data.Leave a review
Not enough review data.Leave a review
Side effects
The Sinemet (carbidopa / levodopa) FDA package insert doesn’t have numbers about how common side effects are.
The Symmetrel (amantadine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Falling asleep during the day

    Taking other medicines for Parkinson's

  • High fever and confusion

    Stopping Sinemet (carbidopa / levodopa) suddenly

  • Lack of impulse control

    Taking other medicines for Parkinson's disease

See more detailed risks and warnings
  • Deaths from overdosage

    Kidney damage or failure

  • Higher risk of suicide

    Taking Symmetrel (amantadine) for the flu

  • Higher risk of seizures

    History of seizures

  • Heart failure

    Heart failure

    ...and 1 more risk factors

  • Lack of impulse control

    Taking other medicines for Parkinson's disease

See more detailed risks and warnings