Compare carbidopa vs. Apokyn

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lodosyn
(carbidopa)

Apokyn
(apomorphine)

Treats Parkinson's disease when given with levodopa. Lodosyn (carbidopa) enhances the effect of levodopa. It cannot relieve symptoms of Parkinson's disease when taken by itself.Helps you move around. Apokyn (apomorphine) is good for treating the "off" episodes or difficulty moving around when you have advanced Parkinson's disease, but it can cause vomiting and sudden sleepiness.
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Reviews & ratings
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Have you used Lodosyn (carbidopa)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Apokyn (apomorphine)?
Worth itNot sureNot worth it
Side effects
carbidopaApokyn

We haven’t found good data for carbidopa side effects.

FDA side effect reports for carbidopa »
  • Yawning 40%
  • Movement problems 24%
  • Drowsiness or sleepiness 35%
  • Nausea or vomiting 19%
  • Dizziness 20%
  • Runny nose 20%
  • Chest pain 15%
  • Hallucinations 10%
  • Swelling in arms and legs 10%
More Apokyn side effects »
How it works
carbidopaApokyn
Lodosyn (carbidopa) is a decarboxylase inhibitor that allows levodopa to enter the brain and relieve symptoms of Parkinson's disease.Apokyn (apomorphine) is a non-ergoline dopamine agonist. Apokyn (apomorphine) allows you to move around more freely by stimulating the brain's ability to use dopamine, which is important for movement.
Type of medication
carbidopaApokyn
Prescription only
Prescription only
Available as
carbidopaApokyn
  • Pill
  • Injection
Used for
carbidopaApokyn
Risk factors for serious side effects
carbidopaApokyn
    Detailed Lodosyn (carbidopa) risks & warnings »
      • Taking antipsychotic medicines
      • Taking other medicines for Parkinson's disease
      • History of heart disease or stroke
          Detailed Apokyn (apomorphine) risks & warnings »
          Pregnancy

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Sleep
          carbidopaApokyn
          No sleep related info.
          • Apokyn (apomorphine) can make you sleepy or fall asleep without warning. Don't drive or do anything that requires concentration until you know how it affects you.
          • Apokyn (apomorphine) can make you sleepy or fall asleep suddenly without warning. Don't drive or do anything that requires your full concentration until you know how Apokyn (apomorphine) affects you. You're more at risk if you're taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
          Upsides and benefits
          carbidopaApokyn
          • Extra doses of Lodosyn (carbidopa) allows you to get more out of levodopa, especially in later stages of the disease.
          • It is available in a combination pill with levodopa once you find the right dose that works for you.
          • Preferred drug according to the guidelines to treat the "off" periods or inability to control movements well that's associated with Parkinson's.
          • People respond to the injection of Apokyn (apomorphine) very quickly and this response can last longer than other medicines.
          Downsides and risks
          carbidopaApokyn
          • Your doctor may need to change the dose of Lodosyn (carbidopa) frequently before finding the right dose.
          • Can cause vomiting and sudden sleepiness. Your doctor will have to give you a medicine to stop the vomiting from happening.
          • Apokyn (apomorphine) should only be used if you have an "off" period of moving around. You should keep using your other medicines for your Parkinson's.
          • Dosing can be confusing since the pen only dispenses in milliliters, and there have been reports of people getting overdoses of Apokyn (apomorphine) because they thought it was for milligrams.
          • Stopping Apokyn (apomorphine) suddenly or lowering the dose too quickly can cause your muscles to become very stiff and you might get a very high fever, which can be life threatening. Talk to your doctor if you want to stop taking this medicine.
          Tips from our pharmacists for people taking the medication
          carbidopaApokyn
          • Lodosyn (carbidopa) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
          • Your saliva, sweat and urine may have dark color and stain your clothing while taking Lodosyn (carbidopa).
          • Take Lodosyn (carbidopa) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
          • Lodosyn (carbidopa) doesn't work when taken by itself. Don't stop taking your other medicines for Parkinson's disease.
          • Lodosyn (carbidopa) may cause unusual cravings in some people.
          • Apokyn (apomorphine) can cause nausea, so your doctor will give you medicine to help stop that and vomiting.
          • Your doctor will tell you how much Apokyn (apomorphine) you will inject. This is given in milliliters. Turn the pen so that the correct dose is given.
          • Apokyn (apomorphine) can make you sleepy or fall asleep without warning. Don't drive or do anything that requires concentration until you know how it affects you.
          • Always change where you inject Apokyn (apomorphine) and always use a fresh needle every time. This will make injecting safer and less painful.
          • If the liquid inside the Apokyn (apomorphine) cartridge does not look clear and colorless, don't use it. Use a new cartridge or call your pharmacy.
          • Can cause you to feel faint, especially if you get up after sitting or lying down for a while. Be careful moving around after you use Apokyn (apomorphine) so you don't fall.
          Learn more
          More about carbidopaSide effectsAlternativesFDA package insert
          Have you used Lodosyn (carbidopa)?
          Worth itNot sureNot worth it
          More about ApokynSide effectsAlternativesFDA package insert
          Have you used Apokyn (apomorphine)?
          Worth itNot sureNot worth it