Compare carbidopa vs. Apokyn

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lodosyn (carbidopa)

Prescription only

Apokyn (apomorphine)

Prescription only
Treats Parkinson's disease when given with levodopa.

Lodosyn (carbidopa) enhances the effect of levodopa. It cannot relieve symptoms of Parkinson's disease when taken by itself.

Helps you move around.

Apokyn (apomorphine) is good for treating the "off" episodes or difficulty moving around when you have advanced Parkinson's disease, but it can cause vomiting and sudden sleepiness.

Upsides
  • Extra doses of Lodosyn (carbidopa) allows you to get more out of levodopa, especially in later stages of the disease.
  • It is available in a combination pill with levodopa once you find the right dose that works for you.
  • Preferred drug according to the guidelines to treat the "off" periods or inability to control movements well that's associated with Parkinson's.
  • People respond to the injection of Apokyn (apomorphine) very quickly and this response can last longer than other medicines.
Downsides
  • Your doctor may need to change the dose of Lodosyn (carbidopa) frequently before finding the right dose.
  • Can cause vomiting and sudden sleepiness. Your doctor will have to give you a medicine to stop the vomiting from happening.
  • Apokyn (apomorphine) should only be used if you have an "off" period of moving around. You should keep using your other medicines for your Parkinson's.
  • Dosing can be confusing since the pen only dispenses in milliliters, and there have been reports of people getting overdoses of Apokyn (apomorphine) because they thought it was for milligrams.
  • Stopping Apokyn (apomorphine) suddenly or lowering the dose too quickly can cause your muscles to become very stiff and you might get a very high fever, which can be life threatening. Talk to your doctor if you want to stop taking this medicine.
Used for
Dosage forms
  • Pill
  • Injection
Price
Lowest price
$1035.15
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Reviews
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Side effects
The Lodosyn (carbidopa) FDA package insert doesn’t have numbers about how common side effects are.
9possible side effects
  • Yawning
    40%
  • Movement problems
    35%
  • Drowsiness or sleepiness
    35%
  • Nausea or vomiting
    30%
  • Dizziness
    20%
  • Runny nose
    20%
  • Chest pain
    15%
  • Hallucinations
    10%
  • Swelling in arms and legs
    10%
See more detailed side effects
Risks and risk factors
  • Fainting
  • Hallucinations
    • Taking antipsychotic medicines
  • Falling asleep during the day
    • Taking other medicines for Parkinson's disease
  • Increased risk of heart attack or stroke
    • History of heart disease or stroke
  • Nausea and vomiting
  • Priapism
See more detailed risks and warnings