Compare carbidopa vs. carbidopa / levodopa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lodosyn
(carbidopa)

Sinemet
(carbidopa / levodopa)

Treats Parkinson's disease when given with levodopa. Lodosyn (carbidopa) enhances the effect of levodopa. It cannot relieve symptoms of Parkinson's disease when taken by itself.Treats Parkinson's disease. Sinemet (carbidopa / levodopa) is the first choice treatment for Parkinson's disease.
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Reviews & ratings
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Have you used Lodosyn (carbidopa)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Sinemet (carbidopa / levodopa)?
Worth itNot sureNot worth it
Side effects
carbidopacarbidopa / levodopa

We haven’t found good data for carbidopa side effects.

FDA side effect reports for carbidopa »

The carbidopa / levodopa FDA package insert doesn’t have numbers about how common side effects are.

More about carbidopa / levodopa side effects »
How it works
carbidopacarbidopa / levodopa
Lodosyn (carbidopa) is a decarboxylase inhibitor that allows levodopa to enter the brain and relieve symptoms of Parkinson's disease.Sinemet (carbidopa / levodopa) is a combination of carbidopa and levodopa. Carbidopa prevents breakdown of levodopa allowing it to enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
carbidopacarbidopa / levodopa
Prescription onlyPrescription only
Available as
carbidopacarbidopa / levodopa
  • Pill
  • Pill
  • Dissolving tablet
Used for
carbidopacarbidopa / levodopa
Risk factors for serious side effects
carbidopacarbidopa / levodopa
    Detailed Lodosyn (carbidopa) risks & warnings »
    • Taking other medicines for Parkinson's
    • Stopping Sinemet (carbidopa / levodopa) suddenly
    • Taking other medicines for Parkinson's disease
    Detailed Sinemet (carbidopa / levodopa) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Sleep
    carbidopacarbidopa / levodopa
    No sleep related info.
    • Can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
    • Can make you very sleepy.
    Upsides and benefits
    carbidopacarbidopa / levodopa
    • Extra doses of Lodosyn (carbidopa) allows you to get more out of levodopa, especially in later stages of the disease.
    • It is available in a combination pill with levodopa once you find the right dose that works for you.
    • Sinemet (carbidopa / levodopa) is widely available as a regular pill, a quick dissolving pill or a liquid taken through a feeding tube.
    • Sinemet (carbidopa / levodopa) is available in generic.
    Downsides and risks
    carbidopacarbidopa / levodopa
    • Your doctor may need to change the dose of Lodosyn (carbidopa) frequently before finding the right dose.
    • Can make you very sleepy.
    • Can stain your saliva, sweat and urine a dark color.
    • Will lose its effect over time as your disease progresses.
    • May need to be taken several times during day to control symptoms of Parkinson's disease
    • May cause unusual cravings in some people.
    Tips from our pharmacists for people taking the medication
    carbidopacarbidopa / levodopa
    • Lodosyn (carbidopa) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
    • Your saliva, sweat and urine may have dark color and stain your clothing while taking Lodosyn (carbidopa).
    • Take Lodosyn (carbidopa) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
    • Lodosyn (carbidopa) doesn't work when taken by itself. Don't stop taking your other medicines for Parkinson's disease.
    • Lodosyn (carbidopa) may cause unusual cravings in some people.
    • Can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
    • Can stain your saliva, sweat and urine a dark color.
    • Take Sinemet (carbidopa / levodopa) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
    • If you notice Sinemet (carbidopa / levodopa) wearing off sooner than you'd like, talk to your doctor. How much and how often you take it may need to be adjusted.
    • Sinemet (carbidopa / levodopa) may cause unusual cravings in some people.
    Learn more
    More about carbidopaSide effectsAlternativesFDA package insert
    Have you used Lodosyn (carbidopa)?
    Worth itNot sureNot worth it
    More about carbidopa / levodopaSide effectsAlternativesFDA package insert
    Have you used Sinemet (carbidopa / levodopa)?
    Worth itNot sureNot worth it