Compare carbidopa vs. carbidopa / levodopa / entacapone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lodosyn
(carbidopa)

Stalevo
(carbidopa / levodopa / entacapone)

Treats Parkinson's disease when given with levodopa. Lodosyn (carbidopa) enhances the effect of levodopa. It cannot relieve symptoms of Parkinson's disease when taken by itself.Treats Parkinson's disease. Stalevo (carbidopa / levodopa / entacapone) is a good choice for Parkinson's disease, especially when carbidopa/levodopa starts losing its effect.
Reviews & ratings
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Have you used Lodosyn (carbidopa)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Stalevo (carbidopa / levodopa / entacapone)?
Worth itNot sureNot worth it
Side effects
carbidopacarbidopa / levodopa / entacapone

We haven’t found good data for carbidopa side effects.

FDA side effect reports for carbidopa »
  • Difficulty controlling movements 10%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Discolored urine 10%
  • Muscle rigidity 1%
  • Abdominal pain 4%
  • Dizziness 2%
  • Fatigue 2%
  • Constipation 2%
More carbidopa / levodopa / entacapone side effects »
How it works
carbidopacarbidopa / levodopa / entacapone
Lodosyn (carbidopa) is a decarboxylase inhibitor that allows levodopa to enter the brain and relieve symptoms of Parkinson's disease.Stalevo (carbidopa / levodopa / entacapone) is a combination of carbidopa, levodopa, and entacapone. Entacopone and carbidopa prevent breakdown of levodopa in the body so that levodopa can then enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
carbidopacarbidopa / levodopa / entacapone
Prescription onlyPrescription only
Available as
carbidopacarbidopa / levodopa / entacapone
  • Pill
  • Pill
Used for
carbidopacarbidopa / levodopa / entacapone
Risk factors for serious side effects
carbidopacarbidopa / levodopa / entacapone
    Detailed Lodosyn (carbidopa) risks & warnings »
    • History of stomach ulcers
    Detailed Stalevo (carbidopa / levodopa / entacapone) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Upsides and benefits
    carbidopacarbidopa / levodopa / entacapone
    • Extra doses of Lodosyn (carbidopa) allows you to get more out of levodopa, especially in later stages of the disease.
    • It is available in a combination pill with levodopa once you find the right dose that works for you.
    • It combines three medicines into one pill so you don't have to take so many pills daily.
    • Stalevo (carbidopa / levodopa / entacapone) is available as a generic.
    Downsides and risks
    carbidopacarbidopa / levodopa / entacapone
    • Your doctor may need to change the dose of Lodosyn (carbidopa) frequently before finding the right dose.
    • You would first start by taking Stalevo (carbidopa / levodopa / entacapone) as two different pills, carbidopa/levodopa and entacapone, before you get switched over to Stalevo (carbidopa / levodopa / entacapone).
    • It's less customizable since there are only a few fixed combinations available.
    Tips from our pharmacists for people taking the medication
    carbidopacarbidopa / levodopa / entacapone
    • Lodosyn (carbidopa) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
    • Your saliva, sweat and urine may have dark color and stain your clothing while taking Lodosyn (carbidopa).
    • Take Lodosyn (carbidopa) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
    • Lodosyn (carbidopa) doesn't work when taken by itself. Don't stop taking your other medicines for Parkinson's disease.
    • Lodosyn (carbidopa) may cause unusual cravings in some people.
    • Stalevo (carbidopa / levodopa / entacapone) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
    • Your saliva, sweat and urine may have dark color and stain your clothing while taking Stalevo (carbidopa / levodopa / entacapone).
    • Take Stalevo (carbidopa / levodopa / entacapone) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
    • Stalevo (carbidopa / levodopa / entacapone) may cause unusual cravings in some people.
    Learn more
    More about carbidopaSide effectsAlternativesFDA package insert
    Have you used Lodosyn (carbidopa)?
    Worth itNot sureNot worth it
    More about carbidopa / levodopa / entacaponeSide effectsAlternativesFDA package insert
    Have you used Stalevo (carbidopa / levodopa / entacapone)?
    Worth itNot sureNot worth it