Compare carbidopa vs. carbidopa/levodopa extended release

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lodosyn
(carbidopa)

Sinemet CR
(carbidopa / levodopa extended release)

Treats Parkinson's disease when given with levodopa. Lodosyn (carbidopa) enhances the effect of levodopa. It cannot relieve symptoms of Parkinson's disease when taken by itself.Treats Parkinson's disease. Sinemet CR (carbidopa / levodopa extended release) is the first choice treatment for Parkinson's disease.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Lodosyn (carbidopa)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Sinemet CR (carbidopa / levodopa extended release)?
Worth itNot sureNot worth it
Side effects
carbidopacarbidopa/levodopa extended release

We haven’t found good data for carbidopa side effects.

FDA side effect reports for carbidopa »
  • Difficulty controlling movements 17%
  • Nausea 6%
  • Hallucinations 4%
  • Confusion 4%
  • Dizziness 3%
  • Low mood disorder 2%
  • Urinary tract infection 2%
  • Back pain 2%
  • Unusual dreams 2%
  • Muscle spasms 2%
More carbidopa/levodopa extended release side effects »
How it works
carbidopacarbidopa/levodopa extended release
Lodosyn (carbidopa) is a decarboxylase inhibitor that allows levodopa to enter the brain and relieve symptoms of Parkinson's disease.Sinemet CR (carbidopa / levodopa extended release) is a combination of carbidopa and levodopa that is released in your body over time. Carbidopa prevents breakdown of levodopa so that levodopa can then, enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
carbidopacarbidopa/levodopa extended release
Prescription only
Prescription only
Available as
carbidopacarbidopa/levodopa extended release
  • Pill
  • Extended release
Used for
carbidopacarbidopa/levodopa extended release
Risk factors for serious side effects
carbidopacarbidopa/levodopa extended release
    Detailed Lodosyn (carbidopa) risks & warnings »
    • Taking other medicines for Parkinson's
    • Stopping Sinemet CR (carbidopa / levodopa extended release) suddenly
      • Taking other medicines for Parkinson's disease
        Detailed Sinemet CR (carbidopa / levodopa extended release) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Upsides and benefits
        carbidopacarbidopa/levodopa extended release
        • Extra doses of Lodosyn (carbidopa) allows you to get more out of levodopa, especially in later stages of the disease.
        • It is available in a combination pill with levodopa once you find the right dose that works for you.
        • Sinemet CR (carbidopa / levodopa extended release) is released over a long period of time in your body and can allow you to take fewer pills less frequently.
        Downsides and risks
        carbidopacarbidopa/levodopa extended release
        • Your doctor may need to change the dose of Lodosyn (carbidopa) frequently before finding the right dose.
        • Sinemet CR (carbidopa / levodopa extended release) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
        • Your saliva, sweat and urine may have dark color and stain your clothing while taking Sinemet CR (carbidopa / levodopa extended release).
        • Sinemet CR (carbidopa / levodopa extended release) will lose its effect over time. If you notice it wearing off sooner than you'd like, talk to your doctor.
        • Sinemet CR (carbidopa / levodopa extended release) may cause unusual cravings in some people.
        Tips from our pharmacists for people taking the medication
        carbidopacarbidopa/levodopa extended release
        • Lodosyn (carbidopa) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
        • Your saliva, sweat and urine may have dark color and stain your clothing while taking Lodosyn (carbidopa).
        • Take Lodosyn (carbidopa) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
        • Lodosyn (carbidopa) doesn't work when taken by itself. Don't stop taking your other medicines for Parkinson's disease.
        • Lodosyn (carbidopa) may cause unusual cravings in some people.
        • Sinemet CR (carbidopa / levodopa extended release) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
        • Your saliva, sweat and urine may have dark color and stain your clothing while taking Sinemet CR (carbidopa / levodopa extended release).
        • Take Sinemet CR (carbidopa / levodopa extended release) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
        • Sinemet CR (carbidopa / levodopa extended release) may cause unusual cravings in some people.
        Learn more
        More about carbidopaSide effectsAlternativesFDA package insert
        Have you used Lodosyn (carbidopa)?
        Worth itNot sureNot worth it
        More about carbidopa/levodopa extended releaseSide effectsAlternativesFDA package insert
        Have you used Sinemet CR (carbidopa / levodopa extended release)?
        Worth itNot sureNot worth it