Compare carbidopa vs. Duopa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lodosyn
(carbidopa)

Duopa
(carbidopa / levodopa)

Treats Parkinson's disease when given with levodopa. Lodosyn (carbidopa) enhances the effect of levodopa. It cannot relieve symptoms of Parkinson's disease when taken by itself.Treats advanced stages of Parkinson's disease. Duopa (carbidopa / levodopa) pumps carbidopa/levodopa into your body throughout the day. It is reserved for advanced Parkinson's disease when your symptoms become more frequent than the dosing of your tablets.
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Prices and coupon for 90 (25mg) tablets of carbidopa
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Prices and coupon for 90 (25mg/100mg) tablets of carbidopa / levodopa
Reviews & ratings
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Have you used Lodosyn (carbidopa)?
Worth itNot sureNot worth it

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Have you used Duopa (carbidopa / levodopa)?
Worth itNot sureNot worth it
Side effects
carbidopaDuopa

We haven’t found good data for carbidopa side effects.

FDA side effect reports for carbidopa »
  • Problems with j-tube 56%
  • Nausea 30%
  • Constipation 22%
  • Redness and swelling at the j-tube site 19%
  • Difficulty controlling movements 14%
  • Low mood disorder 11%
  • Discharge at the j-tube site 11%
  • Swelling in the arms and legs 8%
  • High blood pressure 8%
  • Flu and cold 8%
More Duopa side effects »
How it works
carbidopaDuopa
Lodosyn (carbidopa) is a decarboxylase inhibitor that allows levodopa to enter the brain and relieve symptoms of Parkinson's disease.Duopa (carbidopa / levodopa) is a combination of carbidopa and levodopa. Carbidopa allows levodopa to enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
carbidopaDuopa
Prescription only
Prescription only
Available as
carbidopaDuopa
  • Pill
  • Liquid
Used for
carbidopaDuopa
Risk factors for serious side effects
carbidopaDuopa
    Detailed Lodosyn (carbidopa) risks & warnings »
    • Surgery to place the J-tube
    • Taking other medicines for Parkinson's
    • Stopping Duopa (carbidopa / levodopa) suddenly
      • Taking other medicines for Parkinson's disease
      Detailed Duopa (carbidopa / levodopa) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Pain
      carbidopaDuopa
      No pain related info.
      • Call your doctor right away if you start having stomach pains around where the pump is connected.
      Sleep
      carbidopaDuopa
      No sleep related info.
      • Duopa (carbidopa / levodopa) can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
      • Duopa (carbidopa / levodopa) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Duopa (carbidopa / levodopa) affects you. You're more at risk if you're taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
      Upsides and benefits
      carbidopaDuopa
      • Extra doses of Lodosyn (carbidopa) allows you to get more out of levodopa, especially in later stages of the disease.
      • It is available in a combination pill with levodopa once you find the right dose that works for you.
      • Duopa (carbidopa / levodopa) allows you to have better control of your symptoms than oral tablets, especially in later stages of Parkinson's disease.
      Downsides and risks
      carbidopaDuopa
      • Your doctor may need to change the dose of Lodosyn (carbidopa) frequently before finding the right dose.
      • Given via pump so you'll need to have a procedure to attach the pump to your body.
      • You'll need to take good care of the pump so that it doesn't get disconnected or infected.
      • Duopa (carbidopa / levodopa) only lasts for 16 hours. You may need to take an extra dose of carbidopa/levodopa as tablet for nighttime control.
      • You need to keep Duopa (carbidopa / levodopa) in a fridge, but it should sit at room temperature 20 minutes before infusion.
      Tips from our pharmacists for people taking the medication
      carbidopaDuopa
      • Lodosyn (carbidopa) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
      • Your saliva, sweat and urine may have dark color and stain your clothing while taking Lodosyn (carbidopa).
      • Take Lodosyn (carbidopa) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
      • Lodosyn (carbidopa) doesn't work when taken by itself. Don't stop taking your other medicines for Parkinson's disease.
      • Lodosyn (carbidopa) may cause unusual cravings in some people.
      • Duopa (carbidopa / levodopa) is given via pump. You need to have a minor procedure to connect the pump to your body.
      • You may still need to take carbidopa/levodopa in tablet form at night or if the pump disconnects.
      • Call your doctor right away if you start having stomach pains around where the pump is connected.
      • Duopa (carbidopa / levodopa) is only good for 16 hours. Throw out the cassette when the infusion is done even if there's still medicine left inside.
      • Duopa (carbidopa / levodopa) can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
      • Don't stop taking Duopa (carbidopa / levodopa) suddenly. It can be very dangerous. Talk to your doctor if you want to stop taking Duopa (carbidopa / levodopa).
      Learn more
      More about carbidopaSide effectsAlternativesFDA package insert
      Have you used Lodosyn (carbidopa)?
      Worth itNot sureNot worth it
      More about DuopaSide effectsAlternativesFDA package insert
      Have you used Duopa (carbidopa / levodopa)?
      Worth itNot sureNot worth it