Compare carbidopa vs. entacapone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lodosyn
(carbidopa)

Comtan
(entacapone)

Treats Parkinson's disease when given with levodopa. Lodosyn (carbidopa) enhances the effect of levodopa. It cannot relieve symptoms of Parkinson's disease when taken by itself.Treats Parkinson's disease. Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for carbidopa
Best available price for 90 (25mg) tablets of carbidopa
Coupons for entacapone
Best available price for 90 (200mg) tablets of entacapone
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Lodosyn (carbidopa)
Not enough review data. Review it!
of people (All ages) say Lodosyn (carbidopa) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Lodosyn (carbidopa)?
Worth itNot sureNot worth it
Reviews for Comtan (entacapone)
Not enough review data. Review it!
Same vs. Lodosyn (carbidopa)
Not enough review data. Review it!
Same vs. Lodosyn (carbidopa)
Not enough review data. Review it!
Same vs. Lodosyn (carbidopa)
Have you used Comtan (entacapone)?
Worth itNot sureNot worth it
Side effects
carbidopaentacapone

We haven’t found good data for carbidopa side effects.

FDA side effect reports for carbidopa »
  • Difficulty controlling movements 10%
  • Nausea 6%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Diarrhea 6%
  • Muscle rigidity 1%
  • Dizziness 2%
  • Abdominal pain 4%
  • Fatigue 2%
  • Constipation 2%
More entacapone side effects »
How it works
carbidopaentacapone
Lodosyn (carbidopa) is a decarboxylase inhibitor that allows levodopa to enter the brain and relieve symptoms of Parkinson's disease.Comtan (entacapone) is a COMT inhibitor. It prevents levodopa from breaking down before it enters the brain.
Type of medication
carbidopaentacapone
Prescription only
Prescription only
Available as
carbidopaentacapone
  • Pill
  • Pill
Used for
carbidopaentacapone
Risk factors for serious side effects
carbidopaentacapone
    Detailed Lodosyn (carbidopa) risks & warnings »
    • Taking other medicines for Parkinson's
    • Low blood pressure
    • Taking medicines for high blood pressure
    • Taking other medicines for Parkinson's disease
    Detailed Comtan (entacapone) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Sleep
    carbidopaentacapone
    No sleep related info.
    • Can make you very sleepy
    • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
    • Comtan (entacapone) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Comtan (entacapone) affects you. This is more likely if you're also taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
    Upsides and benefits
    carbidopaentacapone
    • Extra doses of Lodosyn (carbidopa) allows you to get more out of levodopa, especially in later stages of the disease.
    • It is available in a combination pill with levodopa once you find the right dose that works for you.
    • Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
    • Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.
    Downsides and risks
    carbidopaentacapone
    • Your doctor may need to change the dose of Lodosyn (carbidopa) frequently before finding the right dose.
    • Must be taken with other medicines for Parkinson's disease
    • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
    • Can make you very sleepy
    • May require frequent adjustments before finding the dose that works best for you
    Tips from our pharmacists for people taking the medication
    carbidopaentacapone
    • Lodosyn (carbidopa) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
    • Your saliva, sweat and urine may have dark color and stain your clothing while taking Lodosyn (carbidopa).
    • Take Lodosyn (carbidopa) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
    • Lodosyn (carbidopa) doesn't work when taken by itself. Don't stop taking your other medicines for Parkinson's disease.
    • Lodosyn (carbidopa) may cause unusual cravings in some people.
    • Doesn't work by itself. Must be taken with other medicines for Parkinson's disease
    • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
    • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
    • May cause an upset stomach
    • May require frequent adjusting until you the dose that works best
    Learn more
    More about carbidopaSide effectsAlternativesFDA package insert
    Have you used Lodosyn (carbidopa)?
    Worth itNot sureNot worth it
    More about entacaponeSide effectsAlternativesFDA package insert
    Have you used Comtan (entacapone)?
    Worth itNot sureNot worth it