Compare Catapres vs. Neurontin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Catapres
(Clonidine)

Neurontin
(Gabapentin)

Lowers blood pressure. Catapres (Clonidine) is a good addition if you need more than one medicine to control your blood pressure, but it has a lot of side effects. You can't miss doses.Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.223684210526316Catapres
Reviews for Catapres (Clonidine)
42%
of people say Catapres (Clonidine) is worth it
33%
say it works well
34%
say it's a big hassle
Reviews for Neurontin (Gabapentin)
57%
+15% vs. Catapres (Clonidine)
39%
+6% vs. Catapres (Clonidine)
19%
+15% vs. Catapres (Clonidine)
Side effects
CatapresNeurontin

The Catapres FDA package insert doesn’t have numbers about how common side effects are.

More about Catapres side effects »
  • Dizziness 21%
  • Drowsiness 16%
  • Lack of muscle coordination 7%
  • Leg or ankle swelling 6%
  • Fatigue 6%
  • Hostility 5%
  • Involuntary eye movement 4%
  • Double vision 4%
  • Tremor 4%
  • Dry mouth 4%
More Neurontin side effects »
How it works
CatapresNeurontin
Catapres (Clonidine) is an alpha-2 agonist. It works in the brain to tell your blood vessels to relax, and it lowers the activity of certain stress hormones. This lowers blood pressure.Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.
Type of medication
CatapresNeurontin
Antihypertensive
Alpha agonist
Prescription only
Anticonvulsant
GABA analog
Prescription only
Available as
CatapresNeurontin
  • Pill
  • Extended release
  • Patch
  • Pill
  • Oral solution
Used for (click to learn more)
CatapresNeurontin
Risk factors for serious side effects
CatapresNeurontin
  • Sudden discontinuation of medicine
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 years or older
  • Using other medicine(s) that slows the heart
Detailed Catapres (Clonidine) risks & warnings »
    • Children ages 3 to 12
      • Taking with alcohol or drugs
      • Stopping Neurontin (Gabapentin) suddenly
      Detailed Neurontin (Gabapentin) risks & warnings »
      Pregnancy category
      CatapresNeurontin
      Alcohol
      No specific alcohol-related info.
      • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
      Food
      No specific food-related info.
      • Take the extended-release tablet with food.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      • Can cause drowsiness, headache, dizziness, and dry mouth.
      • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      CatapresNeurontin
      • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
      • Available in a weekly patch for people that aren't good at taking medicine by mouth.
      • Works in the brain, so it can help treat some nervous system and psychiatric conditions.
      • Under the brand name Kapvay, it's used to treat ADHD in children and teenagers.
      • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
      • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
      • It's available as a generic, so it's less expensive than similar medications.
      Downsides and risks
      CatapresNeurontin
      • Has a lot of side effects compared to other blood pressure-lowering medicine because it works in the brain.
      • The pill form can make some people sleepy, dizzy, and have dry mouth.
      • You can't miss doses. Stopping Clonidine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
      • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
      • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
      Tips from our pharmacists for people taking the medication
      CatapresNeurontin
      • Usually taken together with other medicines for better blood pressure control.
      • Can cause drowsiness, headache, dizziness, and dry mouth.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • If side effects don't go away, talk to your doctor about alternatives.
      • The weekly patch form can have fewer side effects.
      • Don't stop taking this medicine suddenly.
      • Extended release tablet also used to treat ADHD.
      • Side effects are common, but usually manageable.
      • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
      • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
      • Take the extended-release tablet with food.
      • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
      Learn more
      More about CatapresSide effectsReviews & ratingsAlternativesFDA package insert
      More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert