Compare Catapres vs. Zanaflex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Catapres
(clonidine)

Zanaflex
(tizanidine)

Lowers blood pressure. Catapres (Clonidine) is a good addition if you need more than one medicine to control your blood pressure, but it has a lot of side effects. You can't miss doses.Relaxes your muscles. Zanaflex (Tizanidine) isn't a first-choice treatment for muscle spasms. Try other options before using this.
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Coupons for Catapres
Best available price for 60 (0.1mg) tablets of clonidine
Coupons for Zanaflex
Best available price for 90 (4mg) tablets of tizanidine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.27Catapres
Reviews for Catapres
42%
of people (All ages) say Catapres is worth it
33%
say it works well
35%
say it's a big hassle
Have you used Catapres (clonidine)?
Worth itNot sureNot worth it
Reviews for Zanaflex
81%
-39% worse vs. Catapres
73%
-40% worse vs. Catapres
19%
-16% worse vs. Catapres
Have you used Zanaflex (tizanidine)?
Worth itNot sureNot worth it
Side effects
CatapresZanaflex
  • Redness/itching / pruritis 26%
  • Dry mouth 25%
  • Drowsiness 12%
  • Skin blistering 7%
  • Fatigue 6%
  • Headache 5%
  • Skin or nail darkening 5%
  • Allergic contact sensitization 5%
  • Burning 3%
  • Lack of energy 3%
More Catapres side effects »

We haven’t found good data for Zanaflex side effects.

FDA side effect reports for Zanaflex »
How it works
CatapresZanaflex
Catapres (Clonidine) is an alpha-2 agonist. It works in the brain to tell your blood vessels to relax, and it lowers the activity of certain stress hormones. This lowers blood pressure.Zanaflex (Tizanidine) is a muscle relaxer. It works in the nervous system to calm down muscle spasms without interfering with normal muscle function.
Type of medication
CatapresZanaflex
Prescription onlyPrescription only
Available as
CatapresZanaflex
  • Pill
  • Extended release
  • Patch
  • Pill
Used for
CatapresZanaflex
Risk factors for serious side effects
CatapresZanaflex
  • Sudden discontinuation of medicine
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 years or older
  • Using other medicine(s) that slows the heart
Detailed Catapres (clonidine) risks & warnings »
  • Age 65 years or older
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
Detailed Zanaflex (tizanidine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
CatapresZanaflex
No alcohol related info.
  • Don't drink alcohol while using this.
Food
CatapresZanaflex
No food related info.
  • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
  • Can be taken with or without food, but you need to be consistent in how you take it every day.
  • Need to be consistent every day in taking this with or without food.
Sleep
CatapresZanaflex
  • Can cause drowsiness, headache, dizziness, and dry mouth.
  • Can cause dizziness, fatigue, drowsiness, and dry mouth.
  • Can cause extreme drowsiness or dizziness if you are taking meds for high blood pressure.
Upsides and benefits
CatapresZanaflex
  • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
  • Available in a weekly patch for people that aren't good at taking medicine by mouth.
  • Works in the brain, so it can help treat some nervous system and psychiatric conditions.
  • Under the brand name Kapvay, it's used to treat ADHD in children and teenagers.
  • Relieves muscle spasms well.
  • Can be taken with or without food, but you need to be consistent in how you take it every day.
  • Available as a generic.
  • Available in a tablet or capsule form. It also comes in a capsule that can be opened and sprinkled in applesauce for people that can't swallow pills.
Downsides and risks
CatapresZanaflex
  • Has a lot of side effects compared to other blood pressure-lowering medicine because it works in the brain.
  • The pill form can make some people sleepy, dizzy, and have dry mouth.
  • You can't miss doses. Stopping Clonidine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • This isn't a first-choice muscle relaxing medication. Other drugs work better and have fewer side effects.
  • Zanaflex (Tizanidine) can lower blood pressure, so be careful if you are already on a blood pressure medication.
  • Need to be consistent every day in taking this with or without food.
  • Elderly individuals have more side effects when taking Zanaflex (Tizanidine).
  • Can't stop taking this abruptly if you use it regularly.
Tips from our pharmacists for people taking the medication
CatapresZanaflex
  • Usually taken together with other medicines for better blood pressure control.
  • Can cause drowsiness, headache, dizziness, and dry mouth.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • If side effects don't go away, talk to your doctor about alternatives.
  • The weekly patch form can have fewer side effects.
  • Don't stop taking this medicine suddenly.
  • Extended release tablet also used to treat ADHD.
  • Can cause dizziness, fatigue, drowsiness, and dry mouth.
  • Avoid activities requiring mental alertness (like driving) until you know how it affects you.
  • Can cause extreme drowsiness or dizziness if you are taking meds for high blood pressure.
  • Side effects are more prevalent in the elderly.
  • Don't drink alcohol while using this.
  • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
Learn more
More about CatapresSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Catapres (clonidine)?
Worth itNot sureNot worth it
More about ZanaflexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zanaflex (tizanidine)?
Worth itNot sureNot worth it