Compare Celebrex vs. Acetaminophen with codeine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Celebrex
(Celecoxib)

Tylenol #3
(Acetaminophen / Codeine)

Relieves pain and inflammation. Celebrex (Celecoxib) works well for treating pain and causes less upset stomach than other NSAIDs.Treats mild to moderate pain. Tylenol #3 (Acetaminophen / Codeine) is a good option to treat pain and cough as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.5482041587901705Celebrex
Reviews for Celebrex (Celecoxib)
56%
of people say Celebrex (Celecoxib) is worth it
36%
say it works well
13%
say it's a big hassle
Reviews for Tylenol #3 (Acetaminophen / Codeine)
70%
+14% vs. Celebrex (Celecoxib)
41%
+5% vs. Celebrex (Celecoxib)
9%
+4% vs. Celebrex (Celecoxib)
Side effects
CelebrexAcetaminophen with codeine

We haven’t found good data for Celebrex side effects.

FDA side effect reports for Celebrex »

The Acetaminophen with codeine FDA package insert doesn’t have numbers about how common side effects are.

More about Acetaminophen with codeine side effects »
How it works
CelebrexAcetaminophen with codeine
Celebrex (Celecoxib) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Tylenol #3 (Acetaminophen / Codeine) is a combination pain medicine. Codeine is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
CelebrexAcetaminophen with codeine
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription only
Pain reliever
Acetaminophen (APAP)
Opioid
Prescription only
Available as
CelebrexAcetaminophen with codeine
  • Pill
  • Pill
  • Liquid
Used for (click to learn more)
CelebrexAcetaminophen with codeine
Risk factors for serious side effects
CelebrexAcetaminophen with codeine
  • Long-term use
  • History of heart disease
  • History of heart bypass surgery (coronary artery bypass graft/CABG)
  • Age 65 or older
  • History of GI bleed or peptic ulcer disease
  • History of high blood pressure
  • Taking water pills (diuretics)
  • History of heart failure
    • History of asthma
    • Kidney Disease
    • Heart Failure
    • Liver Disease
    • Also taking diuretics
    • Also taking ACE inhibitors
    • Also taking Angiotensin Receptor Blockers (ARBs)
    • Age 65 or older
    • Late pregnancy (more than 30 weeks)
    Detailed Celebrex (Celecoxib) risks & warnings »
    Coming soon.
    Pregnancy category
    CelebrexAcetaminophen with codeine
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.
    • Avoid alcohol.
    Food
    • Take it with a meal or a snack to prevent an upset stomach.
    • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
    • Take it with food to lower the chance of an upset stomach.
    Kidneys and liver
    • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    • Celebrex (Celecoxib), and similar medications in the NSAID family, can cause lower kidney function or cause permanent kidney damage. You're at higher risk for this if you've a history of kidney disease, heart failure, and liver disease. Taking Diuretic, ACE inhibitor, or Angiotensin Receptor Blocker (ARB) medications also increases your risk. If you are 65 or older you're also at a higher risk for these types of kidney problems.
    No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.
    • Dizziness and drowsiness is common, but your body may adjust.
    • Can make you dizzy or drowsy.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    CelebrexAcetaminophen with codeine
    • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
    • Good for treating muscle aches and pains, as well as menstrual cramps.
    • Causes fewer stomach problems than other NSAIDs like Ibuprofen or Naproxen.
    • Lasts longer than Ibuprofen.
    • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Provides quick relieve for mild to moderate pain to improve quality of life.
    • Good for as-needed pain and control.
    • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
    • Lower rates of misuse compared to pure opioid medicines.
    • Can help you fall asleep easier.
    Downsides and risks
    CelebrexAcetaminophen with codeine
    • The longer you take Celebrex (Celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. Can also happen if you take Celebrex (Celecoxib) on an empty stomach.
    • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
    • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
    • Dizziness and drowsiness is common, but your body may adjust.
    • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Acetaminophen with codeine if you need.
    • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
    • The non-opioid part of Acetaminophen with codeine, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
    • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
    • Avoid alcohol.
    Tips from our pharmacists for people taking the medication
    CelebrexAcetaminophen with codeine
    • Starts working in 1 to 3 hours.
    • Take it with a meal or a snack to prevent an upset stomach.
    • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
    • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Starts working in 30 minutes.
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    • Can make you dizzy or drowsy.
    • Avoid activities need you to be fully alert until you know how it affects you.
    • Take it with food to lower the chance of an upset stomach.
    • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
    • Don't take more than instructed to prevent liver damage.
    • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
    • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
    Learn more
    More about CelebrexSide effectsReviews & ratingsAlternativesFDA package insert
    More about Acetaminophen with codeineSide effectsReviews & ratingsAlternativesFDA package insert