Compare Celebrex vs. Acetaminophen With Codeine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Celebrex (Celecoxib)

Prescription only
Relieves pain and inflammation.

Celebrex (Celecoxib) works well for treating pain and causes less upset stomach than other NSAIDs.

4.6/ 7 average rating with 550 reviewsforCelebrex
Treats mild to moderate pain.

Tylenol #3 (Acetaminophen / Codeine) is a good option to treat pain and cough as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

5.0/ 7 average rating with 581 reviewsforAcetaminophen With Codeine
Upsides
  • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
  • Good for treating muscle aches and pains, as well as menstrual cramps.
  • Causes fewer stomach problems than other NSAIDs like Ibuprofen or Naproxen.
  • Lasts longer than Ibuprofen.
  • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relieve for mild to moderate pain to improve quality of life.
  • Good for as-needed pain and control.
  • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
Downsides
  • The longer you take Celebrex (Celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. Can also happen if you take Celebrex (Celecoxib) on an empty stomach.
  • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
  • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Acetaminophen with codeine if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Acetaminophen with codeine, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
Used for
Dosage forms
  • Pill
  • Pill
  • Liquid
Price
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$25.05
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$6.2
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Reviews
550 
57%
think this treatment is worth it
38%
think this treatment works well
14%
think this treatment is a hassle

Have you used Celebrex (Celecoxib)?

Leave a review
581 
69%
think this treatment is worth it
41%
think this treatment works well
9%
think this treatment is a hassle

Have you used Tylenol #3 (Acetaminophen / Codeine)?

Leave a review
Side effects
The Celebrex (Celecoxib) FDA package insert doesn’t have numbers about how common side effects are.
The Tylenol #3 (Acetaminophen / Codeine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Heart attack and stroke

    Long-term use

    ...and 2 more risk factors

  • Stomach bleeding

    Age 65 or older

    ...and 1 more risk factors

  • Increased blood pressure

    History of high blood pressure

    ...and 1 more risk factors

  • Increased swelling (edema) and fluid retention

    History of heart failure

  • Asthma attacks

    History of asthma

  • Lowered kidney function

    Kidney Disease

    ...and 6 more risk factors

  • Harm to unborn babies

    Late pregnancy (more than 30 weeks)

See more detailed risks and warnings
No information currently available