Compare Celebrex vs. Allopurinol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Celebrex
(celecoxib)

Zyloprim
(allopurinol)

Relieves pain and inflammation. Celebrex (Celecoxib) works well for treating pain and causes less upset stomach than other NSAIDs.Lowers uric acid levels in blood, and prevents gout flare-ups. Zyloprim (allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to start working.
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Coupons for Celebrex
Best available price for 30 (200mg) capsules of celecoxib
Coupons for Allopurinol
Best available price for 30 (300mg) tablets of allopurinol
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.59Celebrex
Reviews for Celebrex (celecoxib)
57%
of people (All ages) say Celebrex (celecoxib) is worth it
38%
say it works well
14%
say it's a big hassle
550 reviews
Have you used Celebrex (celecoxib)?
Worth itNot sureNot worth it
Reviews for Zyloprim (allopurinol)
71%
+14% better vs. Celebrex (celecoxib)
52%
+14% better vs. Celebrex (celecoxib)
5%
+9% better vs. Celebrex (celecoxib)
Have you used Zyloprim (allopurinol)?
Worth itNot sureNot worth it
Side effects
CelebrexAllopurinol

We haven’t found good data for Celebrex side effects.

FDA side effect reports for Celebrex »

The Allopurinol FDA package insert doesn’t have numbers about how common side effects are.

More about Allopurinol side effects »
How it works
CelebrexAllopurinol
Celebrex (Celecoxib) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Zyloprim (allopurinol) is a xanthine oxidase inhibitor. It lowers uric acid levels in your blood, which can stop gout attacks and kidney stones.
Type of medication
CelebrexAllopurinol
Prescription only
Prescription only
Available as
CelebrexAllopurinol
  • Pill
  • Pill
  • Injection
Used for
CelebrexAllopurinol
Risk factors for serious side effects
CelebrexAllopurinol
  • Long-term use
  • History of heart disease
  • History of heart bypass surgery (coronary artery bypass graft/CABG)
  • Age 65 or older
  • History of GI bleed or peptic ulcer disease
Detailed Celebrex (celecoxib) risks & warnings »
  • History of kidney stones
  • Taking other medications that also cause sleepiness
  • Recreational drug use
  • Excessive alcohol use
  • Elderly
Detailed Zyloprim (allopurinol) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
CelebrexAllopurinol
  • Take it with a meal or a snack to prevent an upset stomach.
  • Take with food or milk to prevent an upset stomach.
Kidneys and liver
CelebrexAllopurinol
  • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Celebrex (Celecoxib), and similar medications in the NSAID family, can cause lower kidney function or cause permanent kidney damage. You're at higher risk for this if you've a history of kidney disease, heart failure, and liver disease. Taking Diuretic, ACE inhibitor, or Angiotensin Receptor Blocker (ARB) medications also increases your risk. If you are 65 or older you're also at a higher risk for these types of kidney problems.
  • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
Pain
CelebrexAllopurinol
  • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
  • Good for treating muscle aches and pains, as well as menstrual cramps.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
No pain related info.
Sleep
CelebrexAllopurinol
No sleep related info.
  • Taking Zyloprim (allopurinol) can make you feel sleepy or dizzy, especially if you're taking other medicines that can also make you feel sleepy, or if you're taking recreational drugs or drinking too much alcohol. Avoid driving or doing other tasks that require concentration until you know how this medication affects you. Get up very slowly from a seated or lying down position.
Upsides and benefits
CelebrexAllopurinol
  • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
  • Good for treating muscle aches and pains, as well as menstrual cramps.
  • Causes fewer stomach problems than other NSAIDs like Ibuprofen or Naproxen.
  • Lasts longer than Ibuprofen.
  • Zyloprim (allopurinol) works well to lower uric acid in the body.
  • It is available as a generic medication.
Downsides and risks
CelebrexAllopurinol
  • The longer you take Celebrex (Celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. Can also happen if you take Celebrex (Celecoxib) on an empty stomach.
  • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
  • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
  • Zyloprim (allopurinol) can raise the number of gout attacks in the first few weeks.
  • It can take 2 to 6 weeks to feel the full effects of Zyloprim (allopurinol).
  • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
Tips from our pharmacists for people taking the medication
CelebrexAllopurinol
  • Starts working in 1 to 3 hours.
  • Take it with a meal or a snack to prevent an upset stomach.
  • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
  • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Drink plenty of water while taking Zyloprim (allopurinol).
  • Take with food or milk to prevent an upset stomach.
  • It takes at least 2 to 6 weeks to experience the full benefit of this medicine.
  • Your doctor can run blood tests to make sure the medication is working as it should.
  • During the first few weeks of starting this, you may need to be on a second anti-gout medicine to prevent flare-ups because Zyloprim (allopurinol) can cause gout attacks when you first start it.
  • If you're taking this because you have cancer, your doctor might have to change the doses of some of your chemotherapy drugs.
Learn more
More about CelebrexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Celebrex (celecoxib)?
Worth itNot sureNot worth it
More about AllopurinolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zyloprim (allopurinol)?
Worth itNot sureNot worth it