Compare Celebrex vs. Coumadin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Celebrex
(Celecoxib)

Coumadin
(Warfarin)

Relieves pain and inflammation. Celebrex (Celecoxib) works well for treating pain and causes less upset stomach than other NSAIDs.Prevents blood clots. Coumadin (Warfarin) is an old, cheap, and effective medicine to prevent blood clots, but it requires some monitoring, dose adjustments, and even lifestyle changes.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.5482041587901705Celebrex
Reviews for Celebrex (Celecoxib)
56%
of people say Celebrex (Celecoxib) is worth it
36%
say it works well
13%
say it's a big hassle
Reviews for Coumadin (Warfarin)
61%
+5% vs. Celebrex (Celecoxib)
54%
+18% vs. Celebrex (Celecoxib)
21%
8% vs. Celebrex (Celecoxib)
Side effects
CelebrexCoumadin

We haven’t found good data for Celebrex side effects.

FDA side effect reports for Celebrex »

The Coumadin FDA package insert doesn’t have numbers about how common side effects are.

More about Coumadin side effects »
How it works
CelebrexCoumadin
Celebrex (Celecoxib) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Coumadin (Warfarin) is an anticoagulant blood thinner. It lowers chemicals called clotting factors so that it's harder for your body to form blood clots.
Type of medication
CelebrexCoumadin
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription only
Anticoagulant
Vitamin K antagonist
Prescription only
Available as
CelebrexCoumadin
  • Pill
  • Pill
Used for (click to learn more)
CelebrexCoumadin
Risk factors for serious side effects
CelebrexCoumadin
  • Long-term use
  • History of heart disease
  • History of heart bypass surgery (coronary artery bypass graft/CABG)
  • Age 65 or older
  • History of GI bleed or peptic ulcer disease
  • History of high blood pressure
  • Taking water pills (diuretics)
  • History of heart failure
    • History of asthma
    • Kidney Disease
    • Heart Failure
    • Liver Disease
    • Also taking diuretics
    • Also taking ACE inhibitors
    • Also taking Angiotensin Receptor Blockers (ARBs)
    • Age 65 or older
    • Late pregnancy (more than 30 weeks)
    Detailed Celebrex (Celecoxib) risks & warnings »
    • Dose too high
    • Age greater than 65
    • History of gastrointestinal bleeding
    • High blood pressure
    • Kidney or liver problems
    • Drug interactions
    • Change in lifestyle or diet
    • Illnesses
    • Alcohol
    • Certain genetic makeup
      • Women of childbearing age
      Detailed Coumadin (Warfarin) risks & warnings »
      Pregnancy category
      CelebrexCoumadin
      DFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      XFDA pregnancy category (Unsafe)

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.
      • Many lifestyle factors can affect how well warfarin works, such as diet, alcohol, and activity level, so it's important that you try to stay consistent with your behaviors.
      Food
      • Take it with a meal or a snack to prevent an upset stomach.
      • Eat foods containing consistent amounts of Vitamin K.
      Kidneys and liver
      • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
      • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
      • Celebrex (Celecoxib), and similar medications in the NSAID family, can cause lower kidney function or cause permanent kidney damage. You're at higher risk for this if you've a history of kidney disease, heart failure, and liver disease. Taking Diuretic, ACE inhibitor, or Angiotensin Receptor Blocker (ARB) medications also increases your risk. If you are 65 or older you're also at a higher risk for these types of kidney problems.
      No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      CelebrexCoumadin
      • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
      • Good for treating muscle aches and pains, as well as menstrual cramps.
      • Causes fewer stomach problems than other NSAIDs like Ibuprofen or Naproxen.
      • Lasts longer than Ibuprofen.
      • Oral blood-thinning medicine that prevents blood clots from forming or getting bigger.
      • Prevents complications of blood clots that can cause extreme discomfort or death. Examples include stroke (blood clots in the brain), pulmonary embolism (blood clots in the lungs causing trouble breathing), or deep vein thrombosis (blood clots in the legs causing pain and blood vessel damage).
      • Has an antidote, Vitamin K, in case of a major accidental bleeding.
      • Coumadin (Warfarin) has been around for a long time, so we know a lot about how well it works and what the risks are.
      • It's dirt cheap.
      Downsides and risks
      CelebrexCoumadin
      • The longer you take Celebrex (Celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. Can also happen if you take Celebrex (Celecoxib) on an empty stomach.
      • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
      • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
      • Raises your risk of bleeding and bruising.
      • Requires routine blood testing (called an INR) to see how well the medicine is working for you and to make the dose just right for you.
      • Many lifestyle factors can affect how well warfarin works, such as diet, alcohol, and activity level, so it's important that you try to stay consistent with your behaviors.
      • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
      Tips from our pharmacists for people taking the medication
      CelebrexCoumadin
      • Starts working in 1 to 3 hours.
      • Take it with a meal or a snack to prevent an upset stomach.
      • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
      • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
      • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
      • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
      • The amount you need depends on your diet, other medical problems, and genes.
      • Take it exactly as instructed.
      • Can raise your risk of bleeding or bruising.
      • Requires regular blood tests to get your dose right.
      • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
      • Eat foods containing consistent amounts of Vitamin K.
      • Tell your doctor immediately if you fell or if you have unusual bleeding, bruising, swelling, or changes in vision and coordination.
      • Get a medical bracelet so that people know you're on a blood thinner during an emergency situation.
      Learn more
      More about CelebrexSide effectsReviews & ratingsAlternativesFDA package insert
      More about CoumadinSide effectsReviews & ratingsAlternativesFDA package insert