Compare Celebrex vs. Indocin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Celebrex
(Celecoxib)

Indocin
(Indomethacin)

Relieves pain and inflammation. Celebrex (Celecoxib) works well for treating pain and causes less upset stomach than other NSAIDs.Treats pain and swelling. Indocin (Indomethacin) works well for mild to moderate pain and swelling, but it shouldn't be used long-term since it has some serious side effects.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.5482041587901705Celebrex
Reviews for Celebrex (Celecoxib)
56%
of people say Celebrex (Celecoxib) is worth it
36%
say it works well
13%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
CelebrexIndocin

We haven’t found good data for Celebrex side effects.

FDA side effect reports for Celebrex »
  • Headache 5%
  • Post procedural hemorrhage 5%
  • Post procedural swelling 2%
  • Diarrhea 2%
  • Indigestion 2%
  • Hot flashes 1%
  • Drowsiness 1%
  • Excessive sweating 1%
  • Fainting 1%
  • Decreased appetite 1%
More Indocin side effects »
How it works
CelebrexIndocin
Celebrex (Celecoxib) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Indocin (Indomethacin) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.
Type of medication
CelebrexIndocin
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription only
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription only
Available as
CelebrexIndocin
  • Pill
  • Pill
  • Extended release
  • Liquid
  • Suppository
Used for (click to learn more)
CelebrexIndocin
Risk factors for serious side effects
CelebrexIndocin
  • Long-term use
  • History of heart disease
  • History of heart bypass surgery (coronary artery bypass graft/CABG)
  • Age 65 or older
  • History of GI bleed or peptic ulcer disease
  • History of high blood pressure
  • Taking water pills (diuretics)
  • History of heart failure
    • History of asthma
    • Kidney Disease
    • Heart Failure
    • Liver Disease
    • Also taking diuretics
    • Also taking ACE inhibitors
    • Also taking Angiotensin Receptor Blockers (ARBs)
    • Age 65 or older
    • Late pregnancy (more than 30 weeks)
    Detailed Celebrex (Celecoxib) risks & warnings »
    • History of cardiovascular disease
    • High blood pressure
    • Smoking
    • History of stomach bleeding or ulcers
    • Age 65 years or older
    • Women of childbearing age
    • Asthma
    • Rhinitis
    • Nasal Polyps
    • Aspirin Allergy
    • NSAID Allergy
    • Current kidney problems
    • Current liver problems
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
    • Blood-thinning medicines
    • Low blood platelet count
    Detailed Indocin (Indomethacin) risks & warnings »
    Pregnancy category
    CelebrexIndocin
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    • Take it with a meal or a snack to prevent an upset stomach.
    • Take with food or milk to help prevent upset stomach.
    Kidneys and liver
    • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    • Celebrex (Celecoxib), and similar medications in the NSAID family, can cause lower kidney function or cause permanent kidney damage. You're at higher risk for this if you've a history of kidney disease, heart failure, and liver disease. Taking Diuretic, ACE inhibitor, or Angiotensin Receptor Blocker (ARB) medications also increases your risk. If you are 65 or older you're also at a higher risk for these types of kidney problems.
    • Not a good choice if you have kidney, liver, or stomach problems.
    • Indocin (Indomethacin) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need a different dose. (No dose adjustments are specified on the manufacturer's label.)
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    CelebrexIndocin
    • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
    • Good for treating muscle aches and pains, as well as menstrual cramps.
    • Causes fewer stomach problems than other NSAIDs like Ibuprofen or Naproxen.
    • Lasts longer than Ibuprofen.
    • Effective option to relieve mild to moderate pain and swelling.
    • Treats inflammation problems, such as rheumatoid arthritis, osteoarthritis, and acute gout attacks.
    • In studies, Indocin (Indomethacin) was more effective than Tylenol for treating osteoarthritis pain.
    • It works as well as Celebrex for treating an acute gout attacks.
    • Available in capsules, long-acting capsules, suppositories, and as a suspension. All forms, except the suspension, are available as generic medications.
    Downsides and risks
    CelebrexIndocin
    • The longer you take Celebrex (Celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. Can also happen if you take Celebrex (Celecoxib) on an empty stomach.
    • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
    • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
    • Indocin (Indomethacin) can cause serious heart and stomach problems. The risk goes up the longer you take it, but problems can happen at any time. Don't take Indocin (Indomethacin) any longer than your doctor recommends.
    • Indocin (Indomethacin) raises your risk of bleeding, especially when taken with other blood-thinning medicines.
    • There are similar medicines that you don't have to take as often and can work just as well.
    • Not a good choice if you have kidney, liver, or stomach problems.
    Tips from our pharmacists for people taking the medication
    CelebrexIndocin
    • Starts working in 1 to 3 hours.
    • Take it with a meal or a snack to prevent an upset stomach.
    • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
    • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    • Takes about 30 minutes to start working and can last about 4 to 6 hours.
    • Can cause stomach ulcers or bleeding. Don't take it with other blood-thinning medicines without talking to your doctor first.
    • Can cause headaches. If the headaches continue even after you take a lower dose, talk to your doctor about stopping Indocin (Indomethacin).
    • The long-acting capsules must be swallowed whole. Don't crush them.
    • Take with food or milk to help prevent upset stomach.
    Learn more
    More about CelebrexSide effectsReviews & ratingsAlternativesFDA package insert
    More about IndocinSide effectsReviews & ratingsAlternativesFDA package insert