Compare Celebrex vs. Indocin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Celebrex
(Celecoxib)

Indocin
(Indomethacin)

Relieves pain and inflammation. Celebrex (Celecoxib) works well for treating pain and causes less upset stomach than other NSAIDs.Treats pain and swelling. Indocin (Indomethacin) works well for mild to moderate pain and swelling, but it shouldn't be used long-term since it has some serious side effects.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.59Celebrex
Reviews for Celebrex (Celecoxib)
57%
of people (All ages) say Celebrex (Celecoxib) is worth it
38%
say it works well
14%
say it's a big hassle
550 reviews
Have you used Celebrex (Celecoxib)?
Worth itNot sureNot worth it

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Have you used Indocin (Indomethacin)?
Worth itNot sureNot worth it
Side effects
CelebrexIndocin

We haven’t found good data for Celebrex side effects.

FDA side effect reports for Celebrex »
  • Headache 5%
  • Post procedural hemorrhage 5%
  • Post procedural swelling 2%
  • Diarrhea 2%
  • Indigestion 2%
  • Hot flashes 1%
  • Drowsiness 1%
  • Excessive sweating 1%
  • Fainting 1%
  • Decreased appetite 1%
More Indocin side effects »
How it works
CelebrexIndocin
Celebrex (Celecoxib) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Indocin (Indomethacin) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.
Type of medication
CelebrexIndocin
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription only
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription only
Available as
CelebrexIndocin
  • Pill
  • Pill
  • Extended release
  • Liquid
  • Suppository
Used for (click to learn more)
CelebrexIndocin
Risk factors for serious side effects
CelebrexIndocin
  • Long-term use
  • History of heart disease
  • History of heart bypass surgery (coronary artery bypass graft/CABG)
  • Age 65 or older
  • History of GI bleed or peptic ulcer disease
Detailed risks & warnings »
  • History of cardiovascular disease
  • High blood pressure
  • Smoking
  • History of stomach bleeding or ulcers
  • Age 65 years or older
Detailed risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
CelebrexIndocin
  • Take it with a meal or a snack to prevent an upset stomach.
  • Take with food or milk to help prevent upset stomach.
Kidneys and liver
CelebrexIndocin
  • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Celebrex (Celecoxib), and similar medications in the NSAID family, can cause lower kidney function or cause permanent kidney damage. You're at higher risk for this if you've a history of kidney disease, heart failure, and liver disease. Taking Diuretic, ACE inhibitor, or Angiotensin Receptor Blocker (ARB) medications also increases your risk. If you are 65 or older you're also at a higher risk for these types of kidney problems.
  • Not a good choice if you have kidney, liver, or stomach problems.
  • Indocin (Indomethacin) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need a different dose. (No dose adjustments are specified on the manufacturer's label.)
Pain
CelebrexIndocin
  • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
  • Good for treating muscle aches and pains, as well as menstrual cramps.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • In studies, Indocin (Indomethacin) was more effective than Tylenol for treating osteoarthritis pain.
Upsides and benefits
CelebrexIndocin
  • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
  • Good for treating muscle aches and pains, as well as menstrual cramps.
  • Causes fewer stomach problems than other NSAIDs like Ibuprofen or Naproxen.
  • Lasts longer than Ibuprofen.
  • Effective option to relieve mild to moderate pain and swelling.
  • Treats inflammation problems, such as rheumatoid arthritis, osteoarthritis, and acute gout attacks.
  • In studies, Indocin (Indomethacin) was more effective than Tylenol for treating osteoarthritis pain.
  • It works as well as Celebrex for treating an acute gout attacks.
  • Available in capsules, long-acting capsules, suppositories, and as a suspension. All forms, except the suspension, are available as generic medications.
Downsides and risks
CelebrexIndocin
  • The longer you take Celebrex (Celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. Can also happen if you take Celebrex (Celecoxib) on an empty stomach.
  • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
  • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
  • Indocin (Indomethacin) can cause serious heart and stomach problems. The risk goes up the longer you take it, but problems can happen at any time. Don't take Indocin (Indomethacin) any longer than your doctor recommends.
  • Indocin (Indomethacin) raises your risk of bleeding, especially when taken with other blood-thinning medicines.
  • There are similar medicines that you don't have to take as often and can work just as well.
  • Not a good choice if you have kidney, liver, or stomach problems.
Tips from our pharmacists for people taking the medication
CelebrexIndocin
  • Starts working in 1 to 3 hours.
  • Take it with a meal or a snack to prevent an upset stomach.
  • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
  • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Takes about 30 minutes to start working and can last about 4 to 6 hours.
  • Can cause stomach ulcers or bleeding. Don't take it with other blood-thinning medicines without talking to your doctor first.
  • Can cause headaches. If the headaches continue even after you take a lower dose, talk to your doctor about stopping Indocin (Indomethacin).
  • The long-acting capsules must be swallowed whole. Don't crush them.
  • Take with food or milk to help prevent upset stomach.
Learn more
More about CelebrexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Celebrex (Celecoxib)?
Worth itNot sureNot worth it
More about IndocinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Indocin (Indomethacin)?
Worth itNot sureNot worth it