Compare Celebrex vs. Morphine Sulfate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Celebrex
(celecoxib)

Ms Contin
(morphine sulfate)

Relieves pain and inflammation. Celebrex (Celecoxib) works well for treating pain and causes less upset stomach than other NSAIDs.Treats severe pain. Ms Contin (Morphine Sulfate) provides good long-term pain control without the need to take medicine frequently, but watch out for constipation.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.59Celebrex
Reviews for Celebrex
57%
of people (All ages) say Celebrex is worth it
38%
say it works well
14%
say it's a big hassle
550 reviews
Have you used Celebrex (celecoxib)?
Worth itNot sureNot worth it
Reviews for Morphine Sulfate
55%
+2% better vs. Celebrex
43%
-5% worse vs. Celebrex
20%
+6% better vs. Celebrex
541 reviews
Have you used Ms Contin (morphine sulfate)?
Worth itNot sureNot worth it
Side effects
CelebrexMorphine Sulfate

We haven’t found good data for Celebrex side effects.

FDA side effect reports for Celebrex »

The Morphine Sulfate FDA package insert doesn’t have numbers about how common side effects are.

More about Morphine Sulfate side effects »
How it works
CelebrexMorphine Sulfate
Celebrex (Celecoxib) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Ms Contin (Morphine Sulfate) is an opioid medicine that works in the brain to lower pain perception.
Type of medication
CelebrexMorphine Sulfate
Prescription onlyPrescription only
Available as
CelebrexMorphine Sulfate
  • Pill
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Suppository
Used for
CelebrexMorphine Sulfate
Risk factors for serious side effects
CelebrexMorphine Sulfate
  • Long-term use
  • History of heart disease
  • History of heart bypass surgery (coronary artery bypass graft/CABG)
  • Age 65 or older
  • History of GI bleed or peptic ulcer disease
Detailed Celebrex (celecoxib) risks & warnings »
  • Current use of medicine that affects liver enzyme CYP 3A4
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
Detailed Ms Contin (morphine sulfate) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
CelebrexMorphine Sulfate
  • Take it with a meal or a snack to prevent an upset stomach.
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
CelebrexMorphine Sulfate
  • Celebrex (Celecoxib), and similar medications in the NSAID family, can cause lower kidney function or cause permanent kidney damage. You're at higher risk for this if you've a history of kidney disease, heart failure, and liver disease. Taking Diuretic, ACE inhibitor, or Angiotensin Receptor Blocker (ARB) medications also increases your risk. If you are 65 or older you're also at a higher risk for these types of kidney problems.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
No kidneys and liver related info.
Pain
CelebrexMorphine Sulfate
  • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
  • Good for treating muscle aches and pains, as well as menstrual cramps.
  • Good for chronic pain that requires around-the-clock relief.
  • Doesn't work for as-needed or quick pain relief.
Sleep
CelebrexMorphine Sulfate
No sleep related info.
  • Dizziness and drowsiness is common, but your body may adjust.
Upsides and benefits
CelebrexMorphine Sulfate
  • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
  • Good for treating muscle aches and pains, as well as menstrual cramps.
  • Causes fewer stomach problems than other NSAIDs like Ibuprofen or Naproxen.
  • Lasts longer than Ibuprofen.
  • Provides longer relieve for moderate to severe pain to improve quality of life.
  • Good for chronic pain that requires around-the-clock relief.
  • Might have fewer side effects than other opioid pain relievers.
Downsides and risks
CelebrexMorphine Sulfate
  • The longer you take Celebrex (Celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. Can also happen if you take Celebrex (Celecoxib) on an empty stomach.
  • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
  • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
  • Doesn't work for as-needed or quick pain relief.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Ms Contin (Morphine Sulfate) if you need.
  • Long term use will likely cause physical dependence.
  • Must be weaned slowly off the medicine after use longer than 2 weeks.
Tips from our pharmacists for people taking the medication
CelebrexMorphine Sulfate
  • Starts working in 1 to 3 hours.
  • Take it with a meal or a snack to prevent an upset stomach.
  • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
  • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Opioid pain medicine that provides longer pain relief—up to 12 hours.
  • Works best when taken regularly instead of as-needed.
  • Especially useful for people with chronic pain problems.
  • May not be the best choice for people who have never taken an opioid pain medicine because it lasts so long.
  • Swallow it whole. Don't crush, chew, or split the medicine.
  • Can make you dizzy or drowsy.
  • Avoid activities that need you to be fully alert until you know how it affects you.
  • Take it with food to lower the chance of an upset stomach.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and taking laxatives can help.
  • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
Learn more
More about CelebrexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Celebrex (celecoxib)?
Worth itNot sureNot worth it
More about Morphine SulfateSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Ms Contin (morphine sulfate)?
Worth itNot sureNot worth it