Compare Celebrex vs. Naproxen

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Celebrex
(Celecoxib)

naproxen

Relieves pain and inflammation. Celebrex (Celecoxib) works well for treating pain and causes less upset stomach than other NSAIDs.Relieves pain, fever, and inflammation. Aleve (Naproxen) works well for mild to moderate pain and inflammation, and it lasts longer than other NSAIDs.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.59Celebrex
Reviews for Celebrex
57%
of people (All ages) say Celebrex is worth it
38%
say it works well
14%
say it's a big hassle
550 reviews
Have you used Celebrex (Celecoxib)?
Worth itNot sureNot worth it
Reviews for Naproxen
78%
-21% worse vs. Celebrex
48%
-10% worse vs. Celebrex
5%
-9% worse vs. Celebrex
978 reviews
Have you used Aleve (Naproxen)?
Worth itNot sureNot worth it
Side effects
CelebrexNaproxen

We haven’t found good data for Celebrex side effects.

FDA side effect reports for Celebrex »

The Naproxen FDA package insert doesn’t have numbers about how common side effects are.

More about Naproxen side effects »
How it works
CelebrexNaproxen
Celebrex (Celecoxib) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Aleve (Naproxen) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.
Type of medication
CelebrexNaproxen
Prescription onlyLower-cost generic availablePrescription or OTCLower-cost generic available
Available as
CelebrexNaproxen
  • Pill
  • Pill
  • Delayed release tablet
  • Liquid
Used for
CelebrexNaproxen
Risk factors for serious side effects
CelebrexNaproxen
  • Long-term use
  • History of heart disease
  • History of heart bypass surgery (coronary artery bypass graft/CABG)
  • Age 65 or older
  • History of GI bleed or peptic ulcer disease
Detailed Celebrex (Celecoxib) risks & warnings »
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Smoking
Detailed Aleve (Naproxen) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
CelebrexNaproxen
  • Take it with a meal or a snack to prevent an upset stomach.
  • Take it with a meal or a snack to prevent an upset stomach.
  • It needs to be taken with food to avoid getting an upset stomach.
Kidneys and liver
CelebrexNaproxen
  • Celebrex (Celecoxib), and similar medications in the NSAID family, can cause lower kidney function or cause permanent kidney damage. You're at higher risk for this if you've a history of kidney disease, heart failure, and liver disease. Taking Diuretic, ACE inhibitor, or Angiotensin Receptor Blocker (ARB) medications also increases your risk. If you are 65 or older you're also at a higher risk for these types of kidney problems.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
  • Aleve (Naproxen) is an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Aleve (Naproxen) for any amount of time.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
Pain
CelebrexNaproxen
  • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
  • Good for treating muscle aches and pains, as well as menstrual cramps.
  • Starts relieving pain in 30 to 60 minutes.
  • Works well to relieve pain, swelling, and fevers.
Upsides and benefits
CelebrexNaproxen
  • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
  • Good for treating muscle aches and pains, as well as menstrual cramps.
  • Causes fewer stomach problems than other NSAIDs like Ibuprofen or Naproxen.
  • Lasts longer than Ibuprofen.
  • Works well to relieve pain, swelling, and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Lasts longer than Ibuprofen, so you can take it less often.
  • Aleve (Naproxen) works as well as Aspirin and Indomethacin to treat arthritis pain, and causes fewer stomach problems.
  • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
Downsides and risks
CelebrexNaproxen
  • The longer you take Celebrex (Celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. Can also happen if you take Celebrex (Celecoxib) on an empty stomach.
  • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
  • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
  • It needs to be taken with food to avoid getting an upset stomach.
  • Can't be taken by pregnant women.
  • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
  • Like all NSAIDs, it can raise your risk of having blood clots, heart attack, or stroke.
Tips from our pharmacists for people taking the medication
CelebrexNaproxen
  • Starts working in 1 to 3 hours.
  • Take it with a meal or a snack to prevent an upset stomach.
  • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
  • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Starts relieving pain in 30 to 60 minutes.
  • Take it with a meal or a snack to prevent an upset stomach.
  • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
  • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
Learn more
More about CelebrexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Celebrex (Celecoxib)?
Worth itNot sureNot worth it
More about NaproxenSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Aleve (Naproxen)?
Worth itNot sureNot worth it