Compare Celebrex vs. Norco

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Celebrex
(celecoxib)

Norco
(hydrocodone / acetaminophen)

Relieves pain and inflammation. Celebrex (Celecoxib) works well for treating pain and causes less upset stomach than other NSAIDs.Treats moderate to severe pain. Norco (Hydrocodone / Acetaminophen) is a good option to treat pain as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.59Celebrex
Reviews for Celebrex
57%
of people (All ages) say Celebrex is worth it
38%
say it works well
14%
say it's a big hassle
550 reviews
Have you used Celebrex (celecoxib)?
Worth itNot sureNot worth it
Reviews for Norco
67%
-10% worse vs. Celebrex
44%
-6% worse vs. Celebrex
13%
-1% worse vs. Celebrex
1194 reviews
Have you used Norco (hydrocodone / acetaminophen)?
Worth itNot sureNot worth it
Side effects
CelebrexNorco

We haven’t found good data for Celebrex side effects.

FDA side effect reports for Celebrex »

The Norco FDA package insert doesn’t have numbers about how common side effects are.

More about Norco side effects »
How it works
CelebrexNorco
Celebrex (Celecoxib) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Norco (Hydrocodone / Acetaminophen) is a combination pain medicine. Hydrocodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
CelebrexNorco
Prescription onlyPrescription only
Available as
CelebrexNorco
  • Pill
  • Pill
  • Oral solution
Used for
CelebrexNorco
Risk factors for serious side effects
CelebrexNorco
  • Long-term use
  • History of heart disease
  • History of heart bypass surgery (coronary artery bypass graft/CABG)
  • Age 65 or older
  • History of GI bleed or peptic ulcer disease
Detailed Celebrex (celecoxib) risks & warnings »
  • Current liver disease
  • Taking with alcohol
  • Taking other medicines with acetaminophen
  • Age 65 or greater
  • Higher dose
Detailed Norco (hydrocodone / acetaminophen) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
CelebrexNorco
No alcohol related info.
  • Avoid alcohol.
Food
CelebrexNorco
  • Take it with a meal or a snack to prevent an upset stomach.
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
CelebrexNorco
  • Celebrex (Celecoxib), and similar medications in the NSAID family, can cause lower kidney function or cause permanent kidney damage. You're at higher risk for this if you've a history of kidney disease, heart failure, and liver disease. Taking Diuretic, ACE inhibitor, or Angiotensin Receptor Blocker (ARB) medications also increases your risk. If you are 65 or older you're also at a higher risk for these types of kidney problems.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
  • The acetaminophen component in Norco (Hydrocodone / Acetaminophen) can hurt your liver. Using more than 4000 mg of the acetaminophen (or 12 tablets of Norco (Hydrocodone / Acetaminophen) can cause serious harm to your liver. You may develop life-threatening liver problems that need a liver transplant. Don't take more than your doctor prescribes, and avoid other medicines that have acetaminophen when using Norco (Hydrocodone / Acetaminophen).
  • Don't take more than instructed to prevent liver damage.
Pain
CelebrexNorco
  • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
  • Good for treating muscle aches and pains, as well as menstrual cramps.
  • This is a combination pain medication. It contains both an opioid medicine and acetaminophen (Tylenol).
  • Works best if you take it as soon as you start feeling pain. Starts working in 30 minutes and pain relief lasts 4 to 6 hours.
  • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
  • Combination pain medicine with an opiod component (hydrocodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
Sleep
CelebrexNorco
No sleep related info.
  • Can help you fall asleep easier.
  • Dizziness and drowsiness is common.
Upsides and benefits
CelebrexNorco
  • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
  • Good for treating muscle aches and pains, as well as menstrual cramps.
  • Causes fewer stomach problems than other NSAIDs like Ibuprofen or Naproxen.
  • Lasts longer than Ibuprofen.
  • Combination pain medicine with an opiod component (hydrocodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relief for moderate to severe pain to improve quality of life.
  • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
  • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
Downsides and risks
CelebrexNorco
  • The longer you take Celebrex (Celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. Can also happen if you take Celebrex (Celecoxib) on an empty stomach.
  • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
  • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
  • Dizziness and drowsiness is common.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Norco if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Norco, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
Tips from our pharmacists for people taking the medication
CelebrexNorco
  • Starts working in 1 to 3 hours.
  • Take it with a meal or a snack to prevent an upset stomach.
  • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
  • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • This is a combination pain medication. It contains both an opioid medicine and acetaminophen (Tylenol).
  • Works best if you take it as soon as you start feeling pain. Starts working in 30 minutes and pain relief lasts 4 to 6 hours.
  • Can make you dizzy or drowsy. Avoid activities need you to be fully alert until you know how it affects you.
  • Take it with food to lower the chance of an upset stomach.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
  • Don't take more than instructed to prevent liver damage.
  • Use it for the shortest time and at the lowest dose possible, to lower your chance of becoming addicted.
  • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
Learn more
More about CelebrexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Celebrex (celecoxib)?
Worth itNot sureNot worth it
More about NorcoSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Norco (hydrocodone / acetaminophen)?
Worth itNot sureNot worth it