Compare Celebrex vs. Norco

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Celebrex
(Celecoxib)

Norco
(Hydrocodone / Acetaminophen)

Relieves pain and inflammation. Celebrex (Celecoxib) works well for treating pain and causes less upset stomach than other NSAIDs.Treats moderate to severe pain. Norco (Hydrocodone / Acetaminophen) is a good option to treat pain as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.5482041587901705Celebrex
Reviews for Celebrex (Celecoxib)
56%
of people say Celebrex (Celecoxib) is worth it
36%
say it works well
13%
say it's a big hassle
Reviews for Norco (Hydrocodone / Acetaminophen)
67%
+11% vs. Celebrex (Celecoxib)
44%
+8% vs. Celebrex (Celecoxib)
13%
Same vs. Celebrex (Celecoxib)
Side effects
CelebrexNorco

We haven’t found good data for Celebrex side effects.

FDA side effect reports for Celebrex »

The Norco FDA package insert doesn’t have numbers about how common side effects are.

More about Norco side effects »
How it works
CelebrexNorco
Celebrex (Celecoxib) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Norco (Hydrocodone / Acetaminophen) is a combination pain medicine. Hydrocodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
CelebrexNorco
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription only
Pain reliever
Opioid
Acetaminophen (APAP)
Prescription only
Available as
CelebrexNorco
  • Pill
  • Pill
  • Oral solution
Used for (click to learn more)
CelebrexNorco
Risk factors for serious side effects
CelebrexNorco
  • Long-term use
  • History of heart disease
  • History of heart bypass surgery (coronary artery bypass graft/CABG)
  • Age 65 or older
  • History of GI bleed or peptic ulcer disease
  • History of high blood pressure
  • Taking water pills (diuretics)
  • History of heart failure
    • History of asthma
    • Kidney Disease
    • Heart Failure
    • Liver Disease
    • Also taking diuretics
    • Also taking ACE inhibitors
    • Also taking Angiotensin Receptor Blockers (ARBs)
    • Age 65 or older
    • Late pregnancy (more than 30 weeks)
    Detailed Celebrex (Celecoxib) risks & warnings »
    • Current liver disease
    • Taking with alcohol
    • Taking other medicines with acetaminophen
    • Age 65 or greater
    • Higher dose
    • People with not enough thyroid hormones
    • History of lung problems
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
      • Long-term use of opioids in mother
      • Breastfeeding while taking Norco (Hydrocodone / Acetaminophen)
      • Taking more than the prescribed dose
      • Long-term use
      • History of drug abuse
      Detailed Norco (Hydrocodone / Acetaminophen) risks & warnings »
      Pregnancy category
      CelebrexNorco
      DFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.
      • Avoid alcohol.
      Food
      • Take it with a meal or a snack to prevent an upset stomach.
      • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
      • Take it with food to lower the chance of an upset stomach.
      Kidneys and liver
      • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
      • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
      • Celebrex (Celecoxib), and similar medications in the NSAID family, can cause lower kidney function or cause permanent kidney damage. You're at higher risk for this if you've a history of kidney disease, heart failure, and liver disease. Taking Diuretic, ACE inhibitor, or Angiotensin Receptor Blocker (ARB) medications also increases your risk. If you are 65 or older you're also at a higher risk for these types of kidney problems.
      No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.
      • Dizziness and drowsiness is common.
      • Can make you dizzy or drowsy. Avoid activities need you to be fully alert until you know how it affects you.
      Weight
      No specific weight-related info.
      • Hydrocodone, one of the medications in Norco (Hydrocodone / Acetaminophen) passes into breast milk. Women with a history of long-term opioid use increase the risk of neonatal withdrawal syndrome. Symptoms in the newborn include irritability, vomiting, diarrhea, tremor and lack of weight gain. Opioid withdrawal in infants is a life-threatening emergency and needs medical help right away.
      Upsides and benefits
      CelebrexNorco
      • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
      • Good for treating muscle aches and pains, as well as menstrual cramps.
      • Causes fewer stomach problems than other NSAIDs like Ibuprofen or Naproxen.
      • Lasts longer than Ibuprofen.
      • Combination pain medicine with an opiod component (hydrocodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
      • Provides quick relief for moderate to severe pain to improve quality of life.
      • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
      • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
      • Lower rates of misuse compared to pure opioid medicines.
      • Can help you fall asleep easier.
      Downsides and risks
      CelebrexNorco
      • The longer you take Celebrex (Celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. Can also happen if you take Celebrex (Celecoxib) on an empty stomach.
      • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
      • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
      • Dizziness and drowsiness is common.
      • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Norco if you need.
      • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
      • The non-opioid part of Norco, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
      • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
      • Avoid alcohol.
      Tips from our pharmacists for people taking the medication
      CelebrexNorco
      • Starts working in 1 to 3 hours.
      • Take it with a meal or a snack to prevent an upset stomach.
      • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
      • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
      • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
      • This is a combination pain medication. It contains both an opioid medicine and acetaminophen (Tylenol).
      • Works best if you take it as soon as you start feeling pain. Starts working in 30 minutes and pain relief lasts 4 to 6 hours.
      • Can make you dizzy or drowsy. Avoid activities need you to be fully alert until you know how it affects you.
      • Take it with food to lower the chance of an upset stomach.
      • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
      • Don't take more than instructed to prevent liver damage.
      • Use it for the shortest time and at the lowest dose possible, to lower your chance of becoming addicted.
      • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
      Learn more
      More about CelebrexSide effectsReviews & ratingsAlternativesFDA package insert
      More about NorcoSide effectsReviews & ratingsAlternativesFDA package insert