Compare Celebrex vs. Percocet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Celebrex
(Celecoxib)

Percocet
(Oxycodone / Acetaminophen)

Relieves pain and inflammation. Celebrex (Celecoxib) works well for treating pain and causes less upset stomach than other NSAIDs.Treats moderate to severe pain. Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
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Reviews & ratings
Filter group. All currently selected
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4.5482041587901705Celebrex
Reviews for Celebrex (Celecoxib)
56%
of people (All ages) say Celebrex (Celecoxib) is worth it
36%
say it works well
13%
say it's a big hassle
529 reviews
Have you used Celebrex (Celecoxib)?
Worth itNot sureNot worth it
Reviews for Percocet (Oxycodone / Acetaminophen)
69%
+13% vs. Celebrex (Celecoxib)
49%
+13% vs. Celebrex (Celecoxib)
15%
2% vs. Celebrex (Celecoxib)
1389 reviews
Have you used Percocet (Oxycodone / Acetaminophen)?
Worth itNot sureNot worth it
Side effects
CelebrexPercocet

We haven’t found good data for Celebrex side effects.

FDA side effect reports for Celebrex »

The Percocet FDA package insert doesn’t have numbers about how common side effects are.

More about Percocet side effects »
How it works
CelebrexPercocet
Celebrex (Celecoxib) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Percocet (Oxycodone / Acetaminophen) is a combination pain medicine. Oxycodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
CelebrexPercocet
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription only
Pain reliever
Opioid
Acetaminophen (APAP)
Prescription only
Available as
CelebrexPercocet
  • Pill
  • Pill
  • Oral solution
Used for (click to learn more)
CelebrexPercocet
Risk factors for serious side effects
CelebrexPercocet
  • Long-term use
  • History of heart disease
  • History of heart bypass surgery (coronary artery bypass graft/CABG)
  • Age 65 or older
  • History of GI bleed or peptic ulcer disease
  • History of high blood pressure
  • Taking water pills (diuretics)
  • History of heart failure
    • History of asthma
    • Kidney Disease
    • Heart Failure
    • Liver Disease
    • Also taking diuretics
    • Also taking ACE inhibitors
    • Also taking Angiotensin Receptor Blockers (ARBs)
    • Age 65 or older
    • Late pregnancy (more than 30 weeks)
    Detailed Celebrex (Celecoxib) risks & warnings »
    • Current liver disease
    • Taking with alcohol
    • Taking other medicines with acetaminophen
    • Age 65 or greater
    • Higher dose
    • People with not enough thyroid hormones
    • History of lung problems
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
    • Long-term use of opioids in mother
    • Breastfeeding while taking Percocet (Oxycodone / Acetaminophen)
    • Children age 18 and younger
    • Taking more than prescribed dose
    • Mixing with alcohol or drugs that interact with Percocet (Oxycodone / Acetaminophen)
      • Age 65 years or older
      • Circulation problems
      Detailed Percocet (Oxycodone / Acetaminophen) risks & warnings »
      Pregnancy

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Alcohol
      CelebrexPercocet
      No alcohol related info.
      • Avoid alcohol.
      Food
      CelebrexPercocet
      • Take it with a meal or a snack to prevent an upset stomach.
      • Take it with food to lower the chance of an upset stomach.
      Kidneys and liver
      CelebrexPercocet
      • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
      • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
      • Celebrex (Celecoxib), and similar medications in the NSAID family, can cause lower kidney function or cause permanent kidney damage. You're at higher risk for this if you've a history of kidney disease, heart failure, and liver disease. Taking Diuretic, ACE inhibitor, or Angiotensin Receptor Blocker (ARB) medications also increases your risk. If you are 65 or older you're also at a higher risk for these types of kidney problems.
      • Don't take more than instructed to prevent liver damage.
      • The acetaminophen component in Percocet (Oxycodone / Acetaminophen) can hurt your liver. Using more than 4000 mg of the acetaminophen (or 12 tablets of Percocet (Oxycodone / Acetaminophen) can cause serious harm to your liver that may make you need a liver transplant and can be life-threatening. Don't take more than your doctor prescribes, and avoid other medicines that have acetaminophen when using Percocet (Oxycodone / Acetaminophen).
      Pain
      CelebrexPercocet
      • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
      • Good for treating muscle aches and pains, as well as menstrual cramps.
      • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
      • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
      • Generally considered stronger than Norco or other combination pain medicine for treating pain.
      • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
      • Works best if you take it as soon as you start feeling pain.
      • Pain relief lasts 4-6 hours.
      • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
      Sleep
      CelebrexPercocet
      No sleep related info.
      • Can help you fall asleep easier.
      • Dizziness and drowsiness is common, but your body may adjust.
      Upsides and benefits
      CelebrexPercocet
      • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
      • Good for treating muscle aches and pains, as well as menstrual cramps.
      • Causes fewer stomach problems than other NSAIDs like Ibuprofen or Naproxen.
      • Lasts longer than Ibuprofen.
      • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
      • Provides quick relief for moderate to severe pain to improve quality of life.
      • Generally considered stronger than Norco or other combination pain medicine for treating pain.
      • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
      • Lower rates of misuse compared to pure opioid medicines.
      • Can help you fall asleep easier.
      Downsides and risks
      CelebrexPercocet
      • The longer you take Celebrex (Celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. Can also happen if you take Celebrex (Celecoxib) on an empty stomach.
      • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
      • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
      • Dizziness and drowsiness is common, but your body may adjust.
      • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
      • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
      • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
      • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
      • Avoid alcohol.
      Tips from our pharmacists for people taking the medication
      CelebrexPercocet
      • Starts working in 1 to 3 hours.
      • Take it with a meal or a snack to prevent an upset stomach.
      • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
      • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
      • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
      • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
      • Starts working in 30 minutes.
      • Works best if you take it as soon as you start feeling pain.
      • Pain relief lasts 4-6 hours.
      • Can make you dizzy or drowsy.
      • Avoid activities need you to be fully alert until you know how it affects you.
      • Take it with food to lower the chance of an upset stomach.
      • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
      • Don't take more than instructed to prevent liver damage.
      • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
      • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
      Learn more
      More about CelebrexSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Celebrex (Celecoxib)?
      Worth itNot sureNot worth it
      More about PercocetSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Percocet (Oxycodone / Acetaminophen)?
      Worth itNot sureNot worth it