Compare Celebrex vs. Plavix

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Relieves pain and inflammation. Celebrex (Celecoxib) works well for treating pain and causes less upset stomach than other NSAIDs.Prevents blood clots. Plavix (Clopidogrel) works well to prevent blood clots and heart complications, but watch out for drug interactions.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Reviews for Celebrex (Celecoxib)
of people say Celebrex (Celecoxib) is worth it
say it works well
say it's a big hassle
Reviews for Plavix (Clopidogrel)
+3% vs. Celebrex (Celecoxib)
+13% vs. Celebrex (Celecoxib)
3% vs. Celebrex (Celecoxib)
Side effects

We haven’t found good data for Celebrex side effects.

FDA side effect reports for Celebrex »
  • Minor bleeding 3%
  • Major bleeding 1%
  • Any noncerebral bleeding 1%
More Plavix side effects »
How it works
Celebrex (Celecoxib) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Plavix (Clopidogrel) is an antiplatelet blood thinner. It prevents blood platelets from working, which makes it harder for your body to form blood clots.
Type of medication
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription only
Prescription only
Available as
  • Pill
  • Pill
Used for (click to learn more)
Risk factors for serious side effects
  • Long-term use
  • History of heart disease
  • History of heart bypass surgery (coronary artery bypass graft/CABG)
  • Age 65 or older
  • History of GI bleed or peptic ulcer disease
  • History of high blood pressure
  • Taking water pills (diuretics)
  • History of heart failure
    • History of asthma
    • Kidney Disease
    • Heart Failure
    • Liver Disease
    • Also taking diuretics
    • Also taking ACE inhibitors
    • Also taking Angiotensin Receptor Blockers (ARBs)
    • Age 65 or older
    • Late pregnancy (more than 30 weeks)
    Detailed Celebrex (Celecoxib) risks & warnings »
    • Genetic variation (CYP2C19 poor metabolizer)
    • Drug-interactions
    • Age greater than 65
    • History of gastrointestinal bleeding
    • High blood pressure
    • Liver problems
    • Drug interactions
    • Certain genetic disposition
      Detailed Plavix (Clopidogrel) risks & warnings »
      Pregnancy category
      DFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      No specific alcohol-related info.No specific alcohol-related info.
      • Take it with a meal or a snack to prevent an upset stomach.
      No specific food-related info.
      Kidneys and liver
      • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
      • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
      • Celebrex (Celecoxib), and similar medications in the NSAID family, can cause lower kidney function or cause permanent kidney damage. You're at higher risk for this if you've a history of kidney disease, heart failure, and liver disease. Taking Diuretic, ACE inhibitor, or Angiotensin Receptor Blocker (ARB) medications also increases your risk. If you are 65 or older you're also at a higher risk for these types of kidney problems.
      No specific kidneys and liver-related info.
      No specific sex-related info.No specific sex-related info.
      No specific sleep-related info.No specific sleep-related info.
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
      • Good for treating muscle aches and pains, as well as menstrual cramps.
      • Causes fewer stomach problems than other NSAIDs like Ibuprofen or Naproxen.
      • Lasts longer than Ibuprofen.
      • Thins your blood to protect your heart after a heart attack or after a procedure on your heart.
      • Studies have shown clopidogrel lowers your risk of death or further heart complications.
      Downsides and risks
      • The longer you take Celebrex (Celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. Can also happen if you take Celebrex (Celecoxib) on an empty stomach.
      • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
      • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
      • Raises your risk of bleeding and bruising.
      • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
      • Doesn't work well for people with certain genetic variations.
      Tips from our pharmacists for people taking the medication
      • Starts working in 1 to 3 hours.
      • Take it with a meal or a snack to prevent an upset stomach.
      • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
      • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
      • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
      • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
      • Can raise your risk of bleeding or bruising.
      • Take it exactly as instructed.
      • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
      • Let your doctor know about any fever, weakness, or unusual bleeding or bruising.
      Learn more
      More about CelebrexSide effectsReviews & ratingsAlternativesFDA package insert
      More about PlavixSide effectsReviews & ratingsAlternativesFDA package insert