Compare Celebrex vs. Tylenol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Celebrex
(Celecoxib)

Tylenol Regular Strength
(Acetaminophen)

Relieves pain and inflammation. Celebrex (Celecoxib) works well for treating pain and causes less upset stomach than other NSAIDs.Relieves pain and fever. Tylenol Regular Strength (Acetaminophen) reduces fever and relieves pain well, but it doesn't lower inflammation and swelling.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.5482041587901705Celebrex
Reviews for Celebrex (Celecoxib)
56%
of people (All ages) say Celebrex (Celecoxib) is worth it
36%
say it works well
13%
say it's a big hassle
529 reviews
Have you used Celebrex (Celecoxib)?
Worth itNot sureNot worth it
Reviews for Tylenol Regular Strength (Acetaminophen)
77%
+21% vs. Celebrex (Celecoxib)
37%
+1% vs. Celebrex (Celecoxib)
3%
+10% vs. Celebrex (Celecoxib)
999 reviews
Have you used Tylenol Regular Strength (Acetaminophen)?
Worth itNot sureNot worth it
Side effects
CelebrexTylenol

We haven’t found good data for Celebrex side effects.

FDA side effect reports for Celebrex »

We haven’t found good data for Tylenol side effects.

FDA side effect reports for Tylenol »
How it works
CelebrexTylenol
Celebrex (Celecoxib) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Tylenol Regular Strength (Acetaminophen) reduces fever and relieves pain, but doesn't lower inflammation and swelling.
Type of medication
CelebrexTylenol
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription only
Pain reliever
Acetaminophen (APAP)
Over-the-counter
Available as
CelebrexTylenol
  • Pill
  • Pill
  • Extended release tablet
  • Chewable tablet
  • Dissolving tablet
  • Gelcap
  • Liquid
  • Suppository
Used for (click to learn more)
CelebrexTylenol
Risk factors for serious side effects
CelebrexTylenol
  • Long-term use
  • History of heart disease
  • History of heart bypass surgery (coronary artery bypass graft/CABG)
  • Age 65 or older
  • History of GI bleed or peptic ulcer disease
  • History of high blood pressure
  • Taking water pills (diuretics)
  • History of heart failure
    • History of asthma
    • Kidney Disease
    • Heart Failure
    • Liver Disease
    • Also taking diuretics
    • Also taking ACE inhibitors
    • Also taking Angiotensin Receptor Blockers (ARBs)
    • Age 65 or older
    • Late pregnancy (more than 30 weeks)
    Detailed Celebrex (Celecoxib) risks & warnings »
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
    Detailed Tylenol Regular Strength (Acetaminophen) risks & warnings »
    Pregnancy

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Alcohol
    CelebrexTylenol
    No alcohol related info.
    • Drinking alcohol while taking Tylenol Regular Strength (Acetaminophen) can damage your liver.
    • Heavy alcohol drinkers shouldn't use Tylenol Regular Strength (Acetaminophen) since it can cause serious liver damage.
    Food
    CelebrexTylenol
    • Take it with a meal or a snack to prevent an upset stomach.
    No food related info.
    Kidneys and liver
    CelebrexTylenol
    • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    • Celebrex (Celecoxib), and similar medications in the NSAID family, can cause lower kidney function or cause permanent kidney damage. You're at higher risk for this if you've a history of kidney disease, heart failure, and liver disease. Taking Diuretic, ACE inhibitor, or Angiotensin Receptor Blocker (ARB) medications also increases your risk. If you are 65 or older you're also at a higher risk for these types of kidney problems.
    • Doesn't cause kidney damage and is safe to use if you have heart problems or if you're pregnant.
    • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it's a very common ingredient in pain and cold/flu combination medicines.
    Pain
    CelebrexTylenol
    • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
    • Good for treating muscle aches and pains, as well as menstrual cramps.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    • Works well to relieve pain and fevers.
    • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it's a very common ingredient in pain and cold/flu combination medicines.
    Upsides and benefits
    CelebrexTylenol
    • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
    • Good for treating muscle aches and pains, as well as menstrual cramps.
    • Causes fewer stomach problems than other NSAIDs like Ibuprofen or Naproxen.
    • Lasts longer than Ibuprofen.
    • Works well to relieve pain and fevers.
    • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
    • Tylenol Regular Strength (Acetaminophen) causes less upset stomach, ulcers, bruising, and bleeding than other pain medications like aspirin, ibuprofen, and naproxen.
    • Doesn't cause kidney damage and is safe to use if you have heart problems or if you're pregnant.
    • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
    Downsides and risks
    CelebrexTylenol
    • The longer you take Celebrex (Celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. Can also happen if you take Celebrex (Celecoxib) on an empty stomach.
    • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
    • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
    • Tylenol Regular Strength (Acetaminophen) doesn't treat pain as well as other medications like ibuprofen and naproxen.
    • Drinking alcohol while taking Tylenol Regular Strength (Acetaminophen) can damage your liver.
    • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it's a very common ingredient in pain and cold/flu combination medicines.
    • Heavy alcohol drinkers shouldn't use Tylenol Regular Strength (Acetaminophen) since it can cause serious liver damage.
    Tips from our pharmacists for people taking the medication
    CelebrexTylenol
    • Starts working in 1 to 3 hours.
    • Take it with a meal or a snack to prevent an upset stomach.
    • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
    • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    • Starts working in one hour.
    • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
    • Follow age-specific dosing instructions on how much to take. Adults should never take more than 3,000 milligrams (mg) in a single day.
    • Let your doctor know if your symptoms don't improve in a few days.
    Learn more
    More about CelebrexSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Celebrex (Celecoxib)?
    Worth itNot sureNot worth it
    More about TylenolSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Tylenol Regular Strength (Acetaminophen)?
    Worth itNot sureNot worth it