Compare Celexa vs. Cymbalta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Celexa
(citalopram)

Cymbalta
(duloxetine)

Improves mood and helps you relax. Celexa (Citalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.
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Prices and coupon for 30 (20mg) tablets of citalopram
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Prices and coupon for 30 (60mg) capsules of duloxetine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.98Celexa
Reviews for Celexa (citalopram)
61%
of people (All ages) say Celexa (citalopram) is worth it
51%
say it works well
16%
say it's a big hassle
520 reviews
Have you used Celexa (citalopram)?
Worth itNot sureNot worth it
Reviews for Cymbalta (duloxetine)
58%
-3% worse vs. Celexa (citalopram)
49%
-2% worse vs. Celexa (citalopram)
24%
-8% worse vs. Celexa (citalopram)
496 reviews
Have you used Cymbalta (duloxetine)?
Worth itNot sureNot worth it
Side effects
CelexaCymbalta
  • Nausea 7%
  • Dry mouth 6%
  • Drowsiness 8%
  • Sleep difficulty 1%
  • Sweating increased 2%
  • Diarrhea 3%
  • Tremor 2%
  • Ejaculation disorder 5%
  • Inflammation inside the nose 1%
  • Indigestion 1%
More Celexa side effects »
  • Nausea 15%
  • Headache 2%
  • Dry mouth 8%
  • Somnolencee 7%
  • Fatigue 4%
  • Sleep difficulty 4%
  • Constipation 5%
  • Dizziness 4%
  • Diarrhea 3%
  • Decreased appetite 5%
More Cymbalta side effects »
How it works
CelexaCymbalta
Celexa (Citalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.
Type of medication
CelexaCymbalta
Prescription only
Prescription only
Available as
CelexaCymbalta
  • Pill
  • Oral solution
  • Extended release
Used for
CelexaCymbalta
Risk factors for serious side effects
CelexaCymbalta
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of bipolar disorder
  • At risk for bipolar disorder
  • Stopping Celexa (Citalopram) suddenly
  • Higher dose
  • History of heart problems
  • History of liver problems
  • Older age
  • Taking other blood-thinning drugs
    Detailed Celexa (citalopram) risks & warnings »
    • Age 24 years or younger
    • Using other medications that affect serotonin
    • Stopping Cymbalta (Duloxetine) suddenly
    • History of high blood pressure
    • Taking other blood-thinning drugs
      • History of bipolar disorder
      • At risk for bipolar disorder
      Detailed Cymbalta (duloxetine) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Food
      CelexaCymbalta
      • Take with food to avoid upset stomach.
      • Take with food to avoid upset stomach.
      Kidneys and liver
      CelexaCymbalta
      • Not a good option for you if you have heart or liver problems.
      • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
      Pain
      CelexaCymbalta
      No pain related info.
      • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
      Sex
      CelexaCymbalta
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      No sex related info.
      Weight
      CelexaCymbalta
      • Can cause minor weight gain (1 to 5 pounds).
      No weight related info.
      Upsides and benefits
      CelexaCymbalta
      • Effective at relieving depression and anxiety symptoms.
      • Causes less sleepiness compared to other antidepressants.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      • Effective at relieving depression and anxiety symptoms.
      • Lowers relapse rates for depression.
      • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      Downsides and risks
      CelexaCymbalta
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • Can cause minor weight gain (1 to 5 pounds).
      • Celexa (Citalopram) can cause an irregular heartbeat if you take a high dose (40 mg a day, or more).
      • Not a good option for you if you have heart or liver problems.
      • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24 years.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
      • Not the best option for people with high blood pressure.
      • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      Tips from our pharmacists for people taking the medication
      CelexaCymbalta
      • Take with food to avoid upset stomach.
      • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
      • Stop taking it slowly to avoid getting withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • Take with food to avoid upset stomach.
      • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
      • Stop taking slowly to avoid withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      Learn more
      More about CelexaSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Celexa (citalopram)?
      Worth itNot sureNot worth it
      More about CymbaltaSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Cymbalta (duloxetine)?
      Worth itNot sureNot worth it