Compare Celexa vs. Cymbalta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Celexa
(Citalopram)

Cymbalta
(Duloxetine)

Improves mood and helps you relax. Celexa (Citalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.98Celexa
Reviews for Celexa (Citalopram)
61%
of people (All ages) say Celexa (Citalopram) is worth it
51%
say it works well
16%
say it's a big hassle
520 reviews
Have you used Celexa (Citalopram)?
Worth itNot sureNot worth it
Reviews for Cymbalta (Duloxetine)
58%
3% vs. Celexa (Citalopram)
49%
2% vs. Celexa (Citalopram)
24%
8% vs. Celexa (Citalopram)
496 reviews
Have you used Cymbalta (Duloxetine)?
Worth itNot sureNot worth it
Side effects
CelexaCymbalta
  • Abnormal ejaculation 5%
More Celexa side effects »

The Cymbalta FDA package insert doesn’t have numbers about how common side effects are.

More about Cymbalta side effects »
How it works
CelexaCymbalta
Celexa (Citalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.
Type of medication
CelexaCymbalta
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Available as
CelexaCymbalta
  • Pill
  • Oral solution
  • Extended release
Used for (click to learn more)
CelexaCymbalta
Risk factors for serious side effects
CelexaCymbalta
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of bipolar disorder
  • At risk for bipolar disorder
  • Stopping Celexa (Citalopram) suddenly
Detailed risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Cymbalta (Duloxetine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
CelexaCymbalta
  • Take with food to avoid upset stomach.
  • Take with food to avoid upset stomach.
Kidneys and liver
CelexaCymbalta
  • Not a good option for you if you have heart or liver problems.
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
Pain
CelexaCymbalta
No pain related info.
  • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
Sex
CelexaCymbalta
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
No sex related info.
Weight
CelexaCymbalta
  • Can cause minor weight gain (1 to 5 pounds).
No weight related info.
Upsides and benefits
CelexaCymbalta
  • Causes less sleepiness compared to other antidepressants.
  • Effective at relieving depression and anxiety symptoms.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Lowers relapse rates for depression.
  • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
  • Effective at relieving depression and anxiety symptoms.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides and risks
CelexaCymbalta
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Can cause minor weight gain (1 to 5 pounds).
  • Celexa (Citalopram) can cause an irregular heartbeat if you take a high dose (40 mg a day, or more).
  • Not a good option for you if you have heart or liver problems.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24 years.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
  • Not the best option for people with high blood pressure.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Tips from our pharmacists for people taking the medication
CelexaCymbalta
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Take with food to avoid upset stomach.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
  • Stop taking slowly to avoid withdrawal symptoms.
  • Take with food to avoid upset stomach.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
Learn more
More about CelexaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Celexa (Citalopram)?
Worth itNot sureNot worth it
More about CymbaltaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Cymbalta (Duloxetine)?
Worth itNot sureNot worth it