Compare Celexa vs. Effexor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Celexa
(citalopram)

Effexor
(venlafaxine)

Improves mood and helps you relax. Celexa (Citalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.Improves mood and helps you relax. Effexor (Venlafaxine) is good for treating depression and anxiety. May work when other antidepressants haven't, it's but more likely to cause side effects and withdrawal symptoms than other antidepressants.
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Prices and coupon for 30 (20mg) tablets of citalopram
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Prices and coupon for 60 (75mg) tablets of venlafaxine
Reviews & ratings
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Filter group. All currently selected
4.98Celexa
Reviews for Celexa (citalopram)
61%
of people (All ages) say Celexa (citalopram) is worth it
51%
say it works well
16%
say it's a big hassle
520 reviews
Have you used Celexa (citalopram)?
Worth itNot sureNot worth it
Reviews for Effexor (venlafaxine)
62%
+1% better vs. Celexa (citalopram)
51%
Same vs. Celexa (citalopram)
23%
-7% worse vs. Celexa (citalopram)
577 reviews
Have you used Effexor (venlafaxine)?
Worth itNot sureNot worth it
Side effects
CelexaEffexor
  • Nausea 7%
  • Dry mouth 6%
  • Drowsiness 8%
  • Sleep difficulty 1%
  • Sweating increased 2%
  • Diarrhea 3%
  • Tremor 2%
  • Ejaculation disorder 5%
  • Inflammation inside the nose 1%
  • Indigestion 1%
More Celexa side effects »
  • Nausea 24%
  • Dizziness 19%
  • Sleep difficulty 10%
  • Drowsiness 14%
  • Muscle weakness 12%
  • Loss of appetite 12%
  • Nervousness 10%
  • Sweating 7%
  • Abnormality of accommodation 8%
  • Indigestion 5%
More Effexor side effects »
How it works
CelexaEffexor
Celexa (Citalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Effexor (Venlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulate mood.
Type of medication
CelexaEffexor
Prescription only
Prescription only
Available as
CelexaEffexor
  • Pill
  • Oral solution
  • Pill
  • Extended release
Used for
CelexaEffexor
Risk factors for serious side effects
CelexaEffexor
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of bipolar disorder
  • At risk for bipolar disorder
  • Stopping Celexa (Citalopram) suddenly
  • Higher dose
  • History of heart problems
  • History of liver problems
  • Older age
  • Taking other blood-thinning drugs
    Detailed Celexa (citalopram) risks & warnings »
    • Age 24 years or younger
    • Using other medications that affect serotonin
    • Stopping Effexor (Venlafaxine) suddenly
    • History of high blood pressure
    • Taking other blood-thinning drugs
      • History of bipolar disorder
      • At risk for bipolar disorder
      Detailed Effexor (venlafaxine) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Food
      CelexaEffexor
      • Take with food to avoid upset stomach.
      No food related info.
      Kidneys and liver
      CelexaEffexor
      • Not a good option for you if you have heart or liver problems.
      No kidneys and liver related info.
      Sex
      CelexaEffexor
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      Weight
      CelexaEffexor
      • Can cause minor weight gain (1 to 5 pounds).
      No weight related info.
      Upsides and benefits
      CelexaEffexor
      • Effective at relieving depression and anxiety symptoms.
      • Causes less sleepiness compared to other antidepressants.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      • Effective at relieving depression and anxiety symptoms.
      • Lowers relapse rates of depression.
      • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      • Might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood. Many other antidepressants affect only serotonin, but not norepinephrine too.
      Downsides and risks
      CelexaEffexor
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • Can cause minor weight gain (1 to 5 pounds).
      • Celexa (Citalopram) can cause an irregular heartbeat if you take a high dose (40 mg a day, or more).
      • Not a good option for you if you have heart or liver problems.
      • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24 years.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • Not the best option for people with high blood pressure.
      • Overdosing on this medication could be fatal.
      • It's more likely to cause nausea and vomiting or make you feel sick if you miss a dose than other antidepressants. Also causes more sleepiness than others.
      • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      Tips from our pharmacists for people taking the medication
      CelexaEffexor
      • Take with food to avoid upset stomach.
      • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
      • Stop taking it slowly to avoid getting withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
      • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
      • Extended-release capsules should be swallowed whole. If you can’t swallow pills, open the capsule, sprinkle it on a spoonful of applesauce and then swallow it without chewing.
      • Stop taking it slowly to avoid getting withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      Learn more
      More about CelexaSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Celexa (citalopram)?
      Worth itNot sureNot worth it
      More about EffexorSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Effexor (venlafaxine)?
      Worth itNot sureNot worth it