Compare Celexa vs. Pristiq

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Celexa (citalopram)

Prescription only

Pristiq (Desvenlafaxine)

Prescription only
Improves mood.

Celexa (citalopram) is good for treating depression and anxiety. Side effects are less likely to happen compared to other antidepressants; however, it is not the best choice for people with heart or liver problems.

3.7/ 5 average rating with 520 reviewsforCelexa
Improves mood.

Pristiq (Desvenlafaxine) is basically the same medication as Effexor, which is cheaper because it's available as a generic.

3.5/ 5 average rating with 196 reviewsforPristiq
Upsides
  • Effectively relieves depression symptoms.
  • This medicine is not as drowsy as other antidepressants.
  • Available as a generic, which is cheaper.
  • Effective at relieving symptoms and lowering relapse rates for depression.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides
  • Can cause sexual side effects like decreased sex drive, difficulties with orgasm or ejaculation, and minor weight gain (1 to 5 pounds).
  • Celexa (citalopram) may not be a good option if you have heart or liver problems.
  • Like most antidepressants, Celexa (citalopram) can increase risk of suicidal thoughts and behavior in people younger than 24 years.
  • Similar to Effexor, without any extra benefits in clinical studies.
  • Can cause sexual side effects (usually low libido or the inability to have an orgasm or ejaculate).
  • Not available in generic form, so it's more expensive.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Used for
Dosage forms
  • Pill
  • Liquid
  • Extended release
Price
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Reviews
520 reviews so far
61%
saidit'sworth it
51%
saiditworked well
16%
saidit'sa big hassle

Have you used Celexa (citalopram)?

Leave a review
196 reviews so far
53%
saidit'sworth it
49%
saiditworked well
23%
saidit'sa big hassle

Have you used Pristiq (Desvenlafaxine)?

Leave a review
Side effects
25possible side effects
  • Nausea
    21%
  • Dry mouth
    20%
  • Drowsiness
    18%
  • Difficulty sleeping
    15%
  • Increased sweating
    11%
  • Tremor
    8%
  • Diarrhea
    8%
  • Abnormal ejaculation
    6%
  • Indigestion
    5%
  • Fatigue
    5%
  • Upper airway infection
    5%
  • Stuffy nose
    5%
  • Vomiting
    4%
  • Anxiety
    4%
  • Anorexia
    4%
  • Abdominal pain
    3%
  • Agitation
    3%
  • Menstrual cramps
    3%
  • Sinus infection
    3%
  • Erection difficulties
    3%
  • Fever
    2%
  • Joint pain
    2%
  • Muscle pain
    2%
  • Decreased sex drive
    2%
  • Yawning
    2%
See more detailed side effects
17possible side effects
  • Nausea
    22%
  • Dizziness
    13%
  • Dry mouth
    11%
  • Hyperhidrosis
    10%
  • Constipation
    9%
  • Insomnia
    9%
  • Fatigue
    7%
  • Decreased appetite
    5%
  • Somnolence
    4%
  • Vomiting
    3%
  • Anxiety
    3%
  • Vision blurred
    3%
  • Tremor
    2%
  • Abnormal dreams
    2%
  • Mydriasis
    2%
  • Vertigo
    2%
  • Tinnitus
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Taking tricyclic antidepressants, lithium, tramadol, fentanyl, amphetamines, certain headache medications (triptans), St. John's Wort
  • Bipolar disorder
    • History of bipolar disorder
    • At risk for bipolar disorder
  • Withdrawal
    • Stopping Celexa (citalopram) abruptly
  • Lower maximum dose in some people
    • Higher dose
    • History of heart problems
    • History of liver problems
    • 60 years or older
  • Increased bleeding
    • Taking other blood-thinning drugs (including aspirin, NSAIDs such as Advil, warfarin)
  • Sexual side effects
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Withdrawal
    • Stopping Pristiq (Desvenlafaxine) suddenly
  • High blood pressure
    • History of high blood pressure
  • Increased bleeding
    • Taking other blood-thinning drugs
  • Sexual dysfunction
  • Mania
    • History of bipolar disorder
    • At risk for bipolar disorder
See more detailed risks and warnings