Compare Celexa vs. Prozac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Celexa
(Citalopram)

Prozac
(Fluoxetine)

Improves mood and helps you relax. Celexa (Citalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.Improves mood and helps you relax. Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.954148471615721Celexa
Reviews for Celexa (Citalopram)
60%
of people (All ages) say Celexa (Citalopram) is worth it
50%
say it works well
15%
say it's a big hassle
458 reviews
Have you used Celexa (Citalopram)?
Worth itNot sureNot worth it
Reviews for Prozac (Fluoxetine)
61%
+1% vs. Celexa (Citalopram)
40%
10% vs. Celexa (Citalopram)
16%
1% vs. Celexa (Citalopram)
1200 reviews
Have you used Prozac (Fluoxetine)?
Worth itNot sureNot worth it
Side effects
CelexaProzac
  • Drowsiness 8%
  • Nausea 7%
  • Dry mouth 6%
  • Abnormal ejaculation 5%
  • Ejaculation disorder 5%
  • Diarrhea 3%
  • Tremor 2%
  • Sweating increased 2%
  • Fatigue 2%
  • Loss of appetite 2%
More Celexa side effects »
  • Rash 57%
  • Sleep difficulty 20%
  • Nausea 18%
  • Muscle weakness 12%
  • Drowsiness 10%
  • Tremor 9%
  • Dry mouth 9%
  • Lower sex drive 9%
  • Loss of appetite 7%
  • Anxiety 7%
More Prozac side effects »
How it works
CelexaProzac
Celexa (Citalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Prozac (Fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
CelexaProzac
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Available as
CelexaProzac
  • Pill
  • Oral solution
  • Pill
  • Delayed release capsule
  • Liquid
Used for (click to learn more)
CelexaProzac
Risk factors for serious side effects
CelexaProzac
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of bipolar disorder
  • At risk for bipolar disorder
  • Stopping Celexa (Citalopram) suddenly
  • Higher dose
  • History of heart problems
  • History of liver problems
  • Older age
  • Taking other blood-thinning drugs
    Detailed Celexa (Citalopram) risks & warnings »
    • Age 24 years or younger
    • Using other medications that affect serotonin
    • Stopping Prozac (Fluoxetine) suddenly
    • History of heart problems
    • History of liver problems
    • Drug interactions
    • Taking other blood-thinning drugs
      • History of bipolar disorder
      • At risk for bipolar disorder
      Detailed Prozac (Fluoxetine) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Food
      CelexaProzac
      • Take with food to avoid upset stomach.
      • Take in the morning with food to avoid side effects.
      Kidneys and liver
      CelexaProzac
      • Not a good option for you if you have heart or liver problems.
      No kidneys and liver related info.
      Sex
      CelexaProzac
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      Weight
      CelexaProzac
      • Can cause minor weight gain (1 to 5 pounds).
      No weight related info.
      Upsides and benefits
      CelexaProzac
      • Causes less sleepiness compared to other antidepressants.
      • Effective at relieving depression and anxiety symptoms.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      • Lowers relapse rates of depression and bulimia nervosa.
      • Causes less sleepiness than other antidepressants.
      • It's more energizing than other antidepressants, so it's good for people who have low energy.
      • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
      • Effective at relieving depression and anxiety symptoms.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      Downsides and risks
      CelexaProzac
      • Can cause minor weight gain (1 to 5 pounds).
      • Celexa (Citalopram) can cause an irregular heartbeat if you take a high dose (40 mg a day, or more).
      • Not a good option for you if you have heart or liver problems.
      • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24 years.
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
      • More likely than other antidepressants to interact with other medications you're taking.
      • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      Tips from our pharmacists for people taking the medication
      CelexaProzac
      • Take with food to avoid upset stomach.
      • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
      • Stop taking it slowly to avoid getting withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • Take in the morning with food to avoid side effects.
      • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
      • Stop taking it slowly to avoid getting withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      Learn more
      More about CelexaSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Celexa (Citalopram)?
      Worth itNot sureNot worth it
      More about ProzacSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Prozac (Fluoxetine)?
      Worth itNot sureNot worth it