Compare Celexa vs. Zoloft

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Celexa
(citalopram)

Zoloft
(sertraline)

Improves mood and helps you relax. Celexa (Citalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.
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Prices and coupon for 30 (20mg) tablets of citalopram
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Prices and coupon for 30 (100mg) tablets of sertraline
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.98Celexa
Reviews for Celexa (citalopram)
61%
of people (All ages) say Celexa (citalopram) is worth it
51%
say it works well
16%
say it's a big hassle
520 reviews
Have you used Celexa (citalopram)?
Worth itNot sureNot worth it
Reviews for Zoloft (sertraline)
59%
-2% worse vs. Celexa (citalopram)
41%
-10% worse vs. Celexa (citalopram)
15%
+1% better vs. Celexa (citalopram)
1472 reviews
Have you used Zoloft (sertraline)?
Worth itNot sureNot worth it
Side effects
CelexaZoloft
  • Nausea 7%
  • Dry mouth 6%
  • Drowsiness 8%
  • Sleep difficulty 1%
  • Sweating increased 2%
  • Diarrhea 3%
  • Tremor 2%
  • Ejaculation disorder 5%
  • Inflammation inside the nose 1%
  • Indigestion 1%
More Celexa side effects »
  • Nausea 10%
  • Diarrhea/loose stools 6%
  • Sleep difficulty 2%
  • Mouth dry 7%
  • Fatigue 10%
  • Dizziness 2%
  • Feeling unwell 2%
  • Indigestion 4%
  • Loss of appetite 5%
  • Lower sex drive 2%
More Zoloft side effects »
How it works
CelexaZoloft
Celexa (Citalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.
Type of medication
CelexaZoloft
Prescription only
Prescription only
Available as
CelexaZoloft
  • Pill
  • Oral solution
  • Pill
  • Liquid
Used for
CelexaZoloft
Risk factors for serious side effects
CelexaZoloft
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of bipolar disorder
  • At risk for bipolar disorder
  • Stopping Celexa (Citalopram) suddenly
  • Higher dose
  • History of heart problems
  • History of liver problems
  • Older age
  • Taking other blood-thinning drugs
    Detailed Celexa (citalopram) risks & warnings »
    • Under 24 years old
    • Interactions with other medications
        • Stopping Zoloft (Sertraline) suddenly
        • Taking with blood-thinning drugs
        • Elderly
        • Taking with diuretic medications
        Detailed Zoloft (sertraline) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Interactions
        CelexaZoloft
        No interactions related info.
        • It interacts with St. John's Wort and Tryptophan.
        Food
        CelexaZoloft
        • Take with food to avoid upset stomach.
        No food related info.
        Kidneys and liver
        CelexaZoloft
        • Not a good option for you if you have heart or liver problems.
        No kidneys and liver related info.
        Sex
        CelexaZoloft
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        Sleep
        CelexaZoloft
        No sleep related info.
        • Causes less drowsiness than other antidepressants.
        • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
        Weight
        CelexaZoloft
        • Can cause minor weight gain (1 to 5 pounds).
        No weight related info.
        Upsides and benefits
        CelexaZoloft
        • Effective at relieving depression and anxiety symptoms.
        • Causes less sleepiness compared to other antidepressants.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
        • Causes less drowsiness than other antidepressants.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        Downsides and risks
        CelexaZoloft
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        • Can cause minor weight gain (1 to 5 pounds).
        • Celexa (Citalopram) can cause an irregular heartbeat if you take a high dose (40 mg a day, or more).
        • Not a good option for you if you have heart or liver problems.
        • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24 years.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        • More likely to cause diarrhea than other antidepressants.
        • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        Tips from our pharmacists for people taking the medication
        CelexaZoloft
        • Take with food to avoid upset stomach.
        • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
        • Stop taking it slowly to avoid getting withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
        • It interacts with St. John's Wort and Tryptophan.
        • Stop taking it slowly to avoid getting withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        Learn more
        More about CelexaSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Celexa (citalopram)?
        Worth itNot sureNot worth it
        More about ZoloftSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Zoloft (sertraline)?
        Worth itNot sureNot worth it