Compare Celexa vs. Zoloft

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Celexa
(Citalopram)

Zoloft
(Sertraline)

Improves mood and helps you relax. Celexa (Citalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.954148471615721Celexa
Reviews for Celexa (Citalopram)
60%
of people (All ages) say Celexa (Citalopram) is worth it
50%
say it works well
15%
say it's a big hassle
458 reviews
Have you used Celexa (Citalopram)?
Worth itNot sureNot worth it
Reviews for Zoloft (Sertraline)
59%
1% vs. Celexa (Citalopram)
40%
10% vs. Celexa (Citalopram)
15%
Same vs. Celexa (Citalopram)
1299 reviews
Have you used Zoloft (Sertraline)?
Worth itNot sureNot worth it
Side effects
CelexaZoloft
  • Drowsiness 8%
  • Nausea 7%
  • Dry mouth 6%
  • Abnormal ejaculation 5%
  • Ejaculation disorder 5%
  • Diarrhea 3%
  • Tremor 2%
  • Sweating increased 2%
  • Fatigue 2%
  • Loss of appetite 2%
More Celexa side effects »
  • Nausea 19%
  • Ejaculation failure 18%
  • Sleep difficulty 16%
  • Diarrhea/loose stools 14%
  • Fatigue 9%
  • Loss of appetite 9%
  • Lower sex drive 9%
  • Sweating increased 9%
  • Dizziness 8%
  • Indigestion 8%
More Zoloft side effects »
How it works
CelexaZoloft
Celexa (Citalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.
Type of medication
CelexaZoloft
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Available as
CelexaZoloft
  • Pill
  • Oral solution
  • Pill
  • Liquid
Used for (click to learn more)
CelexaZoloft
Risk factors for serious side effects
CelexaZoloft
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of bipolar disorder
  • At risk for bipolar disorder
  • Stopping Celexa (Citalopram) suddenly
  • Higher dose
  • History of heart problems
  • History of liver problems
  • Older age
  • Taking other blood-thinning drugs
    Detailed Celexa (Citalopram) risks & warnings »
    • Under 24 years old
    • Interactions with other medications
        • Stopping Zoloft (Sertraline) suddenly
        • Taking with blood-thinning drugs
        • Elderly
        • Taking with diuretic medications
        Detailed Zoloft (Sertraline) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Interactions
        CelexaZoloft
        No interactions related info.
        • It interacts with St. John's Wort and Tryptophan.
        Food
        CelexaZoloft
        • Take with food to avoid upset stomach.
        No food related info.
        Kidneys and liver
        CelexaZoloft
        • Not a good option for you if you have heart or liver problems.
        No kidneys and liver related info.
        Sex
        CelexaZoloft
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        Sleep
        CelexaZoloft
        No sleep related info.
        • Causes less drowsiness than other antidepressants.
        • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
        Weight
        CelexaZoloft
        • Can cause minor weight gain (1 to 5 pounds).
        No weight related info.
        Upsides and benefits
        CelexaZoloft
        • Effective at relieving depression and anxiety symptoms.
        • Causes less sleepiness compared to other antidepressants.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
        • Causes less drowsiness than other antidepressants.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        Downsides and risks
        CelexaZoloft
        • Can cause minor weight gain (1 to 5 pounds).
        • Celexa (Citalopram) can cause an irregular heartbeat if you take a high dose (40 mg a day, or more).
        • Not a good option for you if you have heart or liver problems.
        • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24 years.
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        • More likely to cause diarrhea than other antidepressants.
        • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        Tips from our pharmacists for people taking the medication
        CelexaZoloft
        • Take with food to avoid upset stomach.
        • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
        • Stop taking it slowly to avoid getting withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        • It interacts with St. John's Wort and Tryptophan.
        • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
        • Stop taking it slowly to avoid getting withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        Learn more
        More about CelexaSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Celexa (Citalopram)?
        Worth itNot sureNot worth it
        More about ZoloftSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Zoloft (Sertraline)?
        Worth itNot sureNot worth it