Compare Chloroquine vs. Methotrexate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aralen Phosphate
(Chloroquine)

methotrexate

Coming soon.Treats cancer and changes how your immune system works. Otrexup (Methotrexate) is a first line treatment for many autoimmune diseases and types of cancer. If you're taking it for a long time, you'll have to get routine blood tests.
Reviews & ratings
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Have you used Aralen Phosphate (Chloroquine)?
Worth itNot sureNot worth it

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Have you used Otrexup (Methotrexate)?
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Side effects
ChloroquineMethotrexate

We haven’t found good data for Chloroquine side effects.

FDA side effect reports for Chloroquine »
  • Rash/pruritus/dermatitis 3%
  • Diarrhea 3%
  • Alopecia 3%
  • Leukopenia 3%
  • Pancytopenia 3%
  • Dizziness 3%
  • Nausea/vomiting 10%
  • Stomatitis 10%
  • Thrombocytopenia 10%
  • Elevated liver function tests 15%
More Methotrexate side effects »
How it works
ChloroquineMethotrexate
Coming soon.Otrexup (Methotrexate) is an anti-cancer and immunosuppressive medication that treats forms of cancer, arthritis, and psoriasis. For cancer, it helps your body destroy cancer cells by blocking building blocks that cancer cells need to grow. For rheumatoid arthritis and psoriasis, it lowers the body's normal immune response and prevents the body from attacking itself.
Type of medication
ChloroquineMethotrexate
Lower-cost generic availablePrescription onlyLower-cost generic available
Available as
ChloroquineMethotrexate
  • Pill
  • Pill
  • Injection
Used for
ChloroquineMethotrexate
  • Malaria Malaria Prophylaxis Non Intestinal Amebic Infection
Risk factors for serious side effects
ChloroquineMethotrexate
    Coming soon.
    • Women of childbearing age
    • Men of childbearing potential
    • Reduced kidney function
    • fluid in the abdomen (ascites)
    • fluid in the lungs (pleural effusion)
    Detailed Otrexup (Methotrexate) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Alcohol
    ChloroquineMethotrexate
    No alcohol related info.
    • Don't use alcohol, NSAIDs (anti-inflammatory medications), or stay in the sun too long.
    • You have to avoid alcohol and being in the sun too long.
    Upsides and benefits
    ChloroquineMethotrexate
    Coming soon
    • Recommended as first line treatment for rheumatoid arthritis.
    • Available as a generic medication. Comes as a tablet, an injection that you give yourself weekly, and as an infusion that you get in your doctor's office or at an infusion center.
    • If you accidentally take too much, there's an antidote to help your body recover.
    Downsides and risks
    ChloroquineMethotrexate
    Coming soon
    • You have to be on birth control for at least 2 to 3 months after you finish Otrexup (Methotrexate) since it can cause birth defects.
    • You have to avoid alcohol and being in the sun too long.
    • You'll have to get blood tests done if you're taking this long-term because it can cause harmful side effects.
    Tips from our pharmacists for people taking the medication
    ChloroquineMethotrexate
    Coming soon
    • Don't use alcohol, NSAIDs (anti-inflammatory medications), or stay in the sun too long.
    • Use birth control and avoid pregnancy for at least 2 months (for women) and 3 months (for men) after you finish Otrexup (Methotrexate).
    • Drink plenty of liquids to stay hydrated while taking this.
    • Take the medication exactly as your doctor or pharmacist tells you. Call your doctor or pharmacist if you're confused.
    Learn more
    More about ChloroquineSide effectsFDA package insert
    Have you used Aralen Phosphate (Chloroquine)?
    Worth itNot sureNot worth it
    More about MethotrexateSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Otrexup (Methotrexate)?
    Worth itNot sureNot worth it