Compare chloroquine vs. Methotrexate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aralen Phosphate
(Chloroquine)

Otrexup
(Methotrexate)

Coming soon.Treats cancer and changes how your immune system works. Otrexup (Methotrexate) is a first line treatment for many autoimmune diseases and types of cancer. If you're taking it for a long time, you'll have to get routine blood tests.
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Side effects
chloroquineMethotrexate

We haven’t found good data for chloroquine side effects.

FDA side effect reports for chloroquine »

The Methotrexate FDA package insert doesn’t have numbers about how common side effects are.

More about Methotrexate side effects »
How it works
chloroquineMethotrexate
Coming soon.Otrexup (Methotrexate) is an anti-cancer and immunosuppressive medication that treats forms of cancer, arthritis, and psoriasis. For cancer, it helps your body destroy cancer cells by blocking building blocks that cancer cells need to grow. For rheumatoid arthritis and psoriasis, it lowers the body's normal immune response and prevents the body from attacking itself.
Type of medication
chloroquineMethotrexate
Coming soon.
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Anticancer
Antimetabolite
Prescription only
Available as
chloroquineMethotrexate
  • Pill
  • Pill
  • Injection
Used for (click to learn more)
chloroquineMethotrexate
  • Malaria Malaria; Prophylaxis Non-intestinal amebic infection
Risk factors for serious side effects
chloroquineMethotrexate
Coming soon.
  • Women of childbearing age
  • Men of childbearing potential
    • Reduced kidney function
    • fluid in the abdomen (ascites)
    • fluid in the lungs (pleural effusion)
    • Long-term use
    • Psoriasis
      • Taking Otrexup (Methotrexate) with high-dose NSAIDs
        • Taking Otrexup (Methotrexate) to treat cancer
        • Rapidly growing tumors
        Detailed Otrexup (Methotrexate) risks & warnings »
        Pregnancy category
        chloroquineMethotrexate
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        XFDA pregnancy category (Unsafe)

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.
        • You have to avoid alcohol and being in the sun too long.
        • Don't use alcohol, NSAIDs (anti-inflammatory medications), or stay in the sun too long.
        Food
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.
        • If you're taking Otrexup (Methotrexate), you’ll need to have your blood checked to avoid toxic effects (blood cells, platelets, liver enzymes, kidney function) and chest X-rays when you start and every 1 to 2 months during treatment. Otrexup (Methotrexate) can also cause malignant lymphoma (cancer of the white blood cells). It can happen when you take low-doses of Otrexup (Methotrexate).
        • You are at higher risk of having toxic symptoms because of too much Otrexup (Methotrexate) in your blood if you have kidney disease, or if you have fluid in the abdomen (ascites) or in the lungs (pleural effusion). Your doctor will monitor your body's reaction to Otrexup (Methotrexate) very closely if they decide you need to be on Otrexup (Methotrexate).
        • Tumor lysis syndrome happens when cancer cells are broken down very quickly and damage the kidneys. The damage can be so bad that people need dialysis. If you're taking Otrexup (Methotrexate) to treat cancer, your doctor can give you medicines and take measures to prevent this reaction.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        chloroquineMethotrexate
        Coming soon.
        • Recommended as first line treatment for rheumatoid arthritis.
        • Available as a generic medication. Comes as a tablet, an injection that you give yourself weekly, and as an infusion that you get in your doctor's office or at an infusion center.
        • If you accidentally take too much, there's an antidote to help your body recover.
        Downsides and risks
        chloroquineMethotrexate
        Coming soon.
        • You have to be on birth control for at least 2 to 3 months after you finish Otrexup (Methotrexate) since it can cause birth defects.
        • You have to avoid alcohol and being in the sun too long.
        • You'll have to get blood tests done if you're taking this long-term because it can cause harmful side effects.
        Tips from our pharmacists for people taking the medication
        chloroquineMethotrexate
        Coming soon.
        • Don't use alcohol, NSAIDs (anti-inflammatory medications), or stay in the sun too long.
        • Use birth control and avoid pregnancy for at least 2 months (for women) and 3 months (for men) after you finish Otrexup (Methotrexate).
        • Drink plenty of liquids to stay hydrated while taking this.
        • Take the medication exactly as your doctor or pharmacist tells you. Call your doctor or pharmacist if you're confused.
        Learn more
        More about chloroquineSide effectsFDA package insert
        More about MethotrexateSide effectsReviews & ratingsAlternativesFDA package insert