Compare chlorpromazine vs. Abilify

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Thorazine
(chlorpromazine)

Abilify
(aripiprazole)

Stabilizes your mood. Thorazine (chlorpromazine) has more side effects than other medicines like it. It is most useful during psychotic episodes because it slows you down quickly.Helps control your thoughts and mood. Abilify (Aripiprazole) is good for treating psychosis and mania, and can help with depression. Less likely to cause side effects than any other antipsychotic, but has a risk of suicidal thoughts for people age 24 and younger.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for chlorpromazine
Best available price for 60 (25mg) tablets of chlorpromazine
Coupons for Abilify
Best available price for 30 (5mg) tablets of aripiprazole
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Thorazine (chlorpromazine)
Not enough review data. Review it!
of people (All ages) say Thorazine (chlorpromazine) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it
Reviews for Abilify (aripiprazole)
44%
+44% better vs. Thorazine (chlorpromazine)
40%
+40% better vs. Thorazine (chlorpromazine)
34%
-34% worse vs. Thorazine (chlorpromazine)
252 reviews
Have you used Abilify (aripiprazole)?
Worth itNot sureNot worth it
Side effects
chlorpromazineAbilify

The chlorpromazine FDA package insert doesn’t have numbers about how common side effects are.

More about chlorpromazine side effects »
  • Headache 4%
  • Agitation 2%
  • Sleep difficulty 5%
  • Anxiety 4%
  • Nausea 4%
  • Restlessness 9%
  • Constipation 4%
  • Vomiting 5%
  • Dizziness 3%
  • Indigestion 2%
More Abilify side effects »
How it works
chlorpromazineAbilify
Thorazine (chlorpromazine) is a derivative of phenothiazine, which regulates dopamine levels in your brain to improve your mood.Abilify (Aripiprazole) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.
Type of medication
chlorpromazineAbilify
Prescription only
Prescription only
Available as
chlorpromazineAbilify
  • Pill
  • Injection
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
Used for
chlorpromazineAbilify
Risk factors for serious side effects
chlorpromazineAbilify
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
  • Asthma
  • COPD
  • Acute respiratory infections
Detailed Thorazine (chlorpromazine) risks & warnings »
  • Elderly patients with dementia
  • Age 24 years or younger
  • History of heart problems
  • Drug interactions
  • People with diabetes
Detailed Abilify (aripiprazole) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
chlorpromazineAbilify
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
No alcohol related info.
Sleep
chlorpromazineAbilify
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
No sleep related info.
Weight
chlorpromazineAbilify
No weight related info.
  • Least likely antipsychotic to cause weight gain.
  • Abilify (Aripiprazole) can cause you to gain weight. Abilify (Aripiprazole) is the least likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
Upsides and benefits
chlorpromazineAbilify
  • Acts fast to slow you down during a psychotic episode.
  • Can also be used for nausea or migraines.
  • Safe for use in children as young as 6 months.
  • Comes in a sugar-coated pill for easy administration.
  • Effective at relieving psychotic symptoms and manic episodes. All antipsychotic medicines are about equally effective.
  • More energizing than other antipsychotics.
  • Fewer side effects than any other antipsychotics.
  • Least likely antipsychotic to cause weight gain.
  • Less likely to cause heart problems compared to some antipsychotics.
  • Studies show that it can also be helpful for depression, especially in women, if your symptoms don't go away with an antidepressant alone.
  • Available as a generic, which is cheaper.
Downsides and risks
chlorpromazineAbilify
  • Has more side effects than other medicines like it.
  • Can affect how your other medicines work.
  • Makes you more sensitive to the sun.
  • Can make you dizzy or lightheaded, especially when injected.
  • Cannot be stopped right away.
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • Can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
Tips from our pharmacists for people taking the medication
chlorpromazineAbilify
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
  • Can cause involuntary muscle movements just like other medicines for your mood.
  • Can dry you out and make you more sensitive to the sun.
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
  • Cannot be stopped suddenly.
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Makes you energized. Take in the morning to avoid difficulty sleeping.
  • For the first week, avoid activities that require you to be alert.
  • May worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
Learn more
More about chlorpromazineSide effectsAlternativesFDA package insert
Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it
More about AbilifySide effectsReviews & ratingsAlternativesFDA package insert
Have you used Abilify (aripiprazole)?
Worth itNot sureNot worth it