Compare chlorpromazine vs. Clozaril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Clozaril (Clozapine)

Prescription only
Stabilizes your mood.

Thorazine (chlorpromazine) has more side effects than other medicines like it. It is most useful during psychotic episodes because it slows you down quickly.

Helps control your thoughts and actions.

Clozaril (Clozapine) treats schizophrenia when other drugs haven't worked, but you'll have to get blood work done regularly and might gain weight.

Upsides
  • Acts fast to slow you down during a psychotic episode.
  • Can also be used for nausea or migraines.
  • Safe for use in children as young as 6 months.
  • Comes in a sugar-coated pill for easy administration.
  • Clinical studies show that Clozaril (Clozapine) is effective in treating schizophrenia when other medications have failed.
  • Has the lowest risk of causing movement problems when compared to other antipsychotic medicines.
  • Clozaril (Clozapine) is available as a normal tablet and as a mint-flavored tablet that dissolves on the tongue without water.
  • Available as a generic, which is cheaper.
Downsides
  • Has more side effects than other medicines like it.
  • Can affect how your other medicines work.
  • Makes you more sensitive to the sun.
  • Can make you dizzy or lightheaded, especially when injected.
  • Cannot be stopped right away.
  • You need to get blood work done every time you can get a prescription filled for Clozaril (Clozapine).
  • You can only get Clozaril (Clozapine) at certain pharmacies that are registered to provide it.
  • If you don't get Clozaril (Clozapine) within 7 days of it being ready at the pharmacy, then you have to get blood work done again and get a new prescription from your doctor.
  • You need to limit the amount of alcohol you drink while on Clozaril (Clozapine).
Used for
Dosage forms
  • Pill
  • Injection
  • Pill
  • Dissolving tablet
  • Liquid
Price
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Reviews
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Side effects
The Thorazine (chlorpromazine) FDA package insert doesn’t have numbers about how common side effects are.
33possible side effects
  • Drowsiness/Sedation
    39%
  • Salivation
    31%
  • Tachycardia
    25%
  • Dizziness/Vertigo
    19%
  • Constipation
    14%
  • Hypotension
    9%
  • Headache
    7%
  • Tremor
    6%
  • Syncope
    6%
  • Sweating
    6%
  • Dry Mouth
    6%
  • Nausea
    5%
  • Visual Disturbances
    5%
  • Fever
    5%
  • Disturbed Sleep/Nightmares
    4%
  • Restlessness
    4%
  • Hypokinesia/Akinesia
    4%
  • Agitation
    4%
  • Hypertension
    4%
  • Abdominal Discomfort/Heartburn
    4%
  • Weight Gain
    4%
  • Seizures (convulsions)
    3%
  • Rigidity
    3%
  • Akathisia
    3%
  • Confusion
    3%
  • Nausea/Vomiting
    3%
  • Vomiting
    3%
  • Leukopenia/Decreased WBC/Neutropenia
    3%
  • Fatigue
    2%
  • Insomnia
    2%
  • Diarrhea
    2%
  • Urinary Abnormalities
    2%
  • Rash
    2%
See more detailed side effects
Risks and risk factors
  • Increased risk of death
    • People over 65 with dementia and psychosis
  • Difficulty controlling movements
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Breathing problems
    • Asthma
    • COPD
    • Acute respiratory infections
  • Heat stroke and dehydration
    • Benign prostatic hypertrophy (BPH)
    • Urinary retention
    • Decreased movement in the intestines
See more detailed risks and warnings
  • Fewer white blood cells
  • Low blood pressure | Slow heartbeat | Fainting
    • Dehydration
    • Taking blood pressure medications
  • Seizures
    • Seizure disorder
    • Alcohol abuse
  • Heart problems
    • History of heart problems
  • Increased risk of death
    • Over 65 and having dementia
  • Weight gain
  • Increased blood sugar
    • Diabetes
  • Increased cholesterol
  • Neuroleptic malignant syndrome (NMS)
  • Tardive dyskinesia
  • Return of schizophrenic symptoms
    • Stopping Clozaril (Clozapine) suddenly
See more detailed risks and warnings