Compare chlorpromazine vs. Compro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Thorazine
(chlorpromazine)

Compro
(prochlorperazine)

Stabilizes your mood. Thorazine (chlorpromazine) has more side effects than other medicines like it. It is most useful during psychotic episodes because it slows you down quickly.Helps you feel less queasy. Compro (Prochlorperazine) can be used to treat severe nausea and vomiting and can be taken orally or rectally, but get ready for a nap.
Reviews & ratings
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Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it
Reviews for Compro
45%
-45% worse vs. chlorpromazine
35%
-35% worse vs. chlorpromazine
35%
+35% better vs. chlorpromazine
Have you used Compro (prochlorperazine)?
Worth itNot sureNot worth it
Side effects
chlorpromazineCompro

The chlorpromazine FDA package insert doesn’t have numbers about how common side effects are.

More about chlorpromazine side effects »

The Compro FDA package insert doesn’t have numbers about how common side effects are.

More about Compro side effects »
How it works
chlorpromazineCompro
Thorazine (chlorpromazine) is a derivative of phenothiazine, which regulates dopamine levels in your brain to improve your mood.Compro (Prochlorperazine) is an antiemetic (anti-nausea medicine). It works by blocking signals in the part of your brain that causes vomiting.
Type of medication
chlorpromazineCompro
Prescription onlyPrescription only
Available as
chlorpromazineCompro
  • Pill
  • Injection
  • Pill
  • Suppository
Used for
chlorpromazineCompro
Risk factors for serious side effects
chlorpromazineCompro
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
  • Asthma
  • COPD
  • Acute respiratory infections
Detailed Thorazine (chlorpromazine) risks & warnings »
  • Over age 65
  • Dementia
  • Taking antipsychotics
  • History of seizures
  • Age over 65
Detailed Compro (prochlorperazine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
chlorpromazineCompro
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
  • Don't drink alcohol to avoid intense side effects.
Pain
chlorpromazineCompro
No pain related info.
  • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Compro.
Sleep
chlorpromazineCompro
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
  • You'll likely feel very sleepy, sluggish, or less alert after taking Compro. Avoid driving or other tasks that require your focused attention; be safe.
  • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
Upsides and benefits
chlorpromazineCompro
  • Acts fast to slow you down during a psychotic episode.
  • Can also be used for nausea or migraines.
  • Safe for use in children as young as 6 months.
  • Comes in a sugar-coated pill for easy administration.
  • Available in generic, so it's cheap.
  • Can be taken by mouth, as a shot, or rectally.
  • Can take anywhere from 10 minutes (by shot) to 60 minutes (rectally) to start working.
Downsides and risks
chlorpromazineCompro
  • Has more side effects than other medicines like it.
  • Can affect how your other medicines work.
  • Makes you more sensitive to the sun.
  • Can make you dizzy or lightheaded, especially when injected.
  • Cannot be stopped right away.
  • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
  • Can't be used by people over 65 because they can be more affected by the side effects.
  • It can make you more likely to get heatstroke.
Tips from our pharmacists for people taking the medication
chlorpromazineCompro
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
  • Can cause involuntary muscle movements just like other medicines for your mood.
  • Can dry you out and make you more sensitive to the sun.
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
  • Cannot be stopped suddenly.
  • Compro comes in different forms. Be clear on which one you were prescribed - swallow tablets orally, unwrap and insert suppositories rectally.
  • You'll likely feel very sleepy, sluggish, or less alert after taking Compro. Avoid driving or other tasks that require your focused attention; be safe.
  • Don't drink alcohol to avoid intense side effects.
  • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Compro.
  • Avoid using if you experience seizures (epilepsy).
  • Don't use if you're 65 or older because you're at higher risk for serious side effects.
Learn more
More about chlorpromazineSide effectsAlternativesFDA package insert
Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it
More about ComproSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Compro (prochlorperazine)?
Worth itNot sureNot worth it