Compare chlorpromazine vs. fluphenazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Thorazine
(chlorpromazine)

Prolixin
(fluphenazine)

Stabilizes your mood. Thorazine (chlorpromazine) has more side effects than other medicines like it. It is most useful during psychotic episodes because it slows you down quickly.Treats schizophrenia and psychosis. Prolixin (fluphenazine) can stabilize your mood. It is used to find the right dose for you before moving to a long-acting injection.
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Coupons for chlorpromazine
Best available price for 60 (25mg) tablets of chlorpromazine
Coupons for fluphenazine
Best available price for 60 (5mg) tablets of fluphenazine
Reviews & ratings
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Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Prolixin (fluphenazine)?
Worth itNot sureNot worth it
Side effects
chlorpromazinefluphenazine

The chlorpromazine FDA package insert doesn’t have numbers about how common side effects are.

More about chlorpromazine side effects »

The fluphenazine FDA package insert doesn’t have numbers about how common side effects are.

More about fluphenazine side effects »
How it works
chlorpromazinefluphenazine
Thorazine (chlorpromazine) is a derivative of phenothiazine, which regulates dopamine levels in your brain to improve your mood.Prolixin (fluphenazine) is a derivative of phenothiazine. It regulates dopamine levels in your brain to control psychotic episodes or schizophrenia.
Type of medication
chlorpromazinefluphenazine
Prescription onlyPrescription only
Available as
chlorpromazinefluphenazine
  • Pill
  • Injection
  • Pill
  • Liquid
  • Injection
Used for
chlorpromazinefluphenazine
Risk factors for serious side effects
chlorpromazinefluphenazine
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
  • Asthma
  • COPD
  • Acute respiratory infections
Detailed Thorazine (chlorpromazine) risks & warnings »
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
Detailed Prolixin (fluphenazine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
chlorpromazinefluphenazine
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
  • Don't combine with alcohol or narcotics since it can stop your breathing.
Sleep
chlorpromazinefluphenazine
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.
Upsides and benefits
chlorpromazinefluphenazine
  • Acts fast to slow you down during a psychotic episode.
  • Can also be used for nausea or migraines.
  • Safe for use in children as young as 6 months.
  • Comes in a sugar-coated pill for easy administration.
  • Good at stabilizing your mood.
  • Available in several oral and injectable forms, including a long-acting injection that is taken less frequently.
Downsides and risks
chlorpromazinefluphenazine
  • Has more side effects than other medicines like it.
  • Can affect how your other medicines work.
  • Makes you more sensitive to the sun.
  • Can make you dizzy or lightheaded, especially when injected.
  • Cannot be stopped right away.
  • Can make you sensitive to the sun.
  • Can affect how your body regulates your temperature.
  • Can make it difficult for you to control your movements if you've been on Prolixin (fluphenazine) for a while.
Tips from our pharmacists for people taking the medication
chlorpromazinefluphenazine
  • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
  • Can cause involuntary muscle movements just like other medicines for your mood.
  • Can dry you out and make you more sensitive to the sun.
  • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
  • Cannot be stopped suddenly.
  • Can make you more sensitive to the sun. Wear sunscreen or protective clothing while outside.
  • Can make it difficult for you to start and stop your movements. Talk to your doctor right away if this happens.
  • Don't combine with alcohol or narcotics since it can stop your breathing.
  • Don't stop taking Prolixin (fluphenazine) suddenly. It can be dangerous.
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Mix the concentrated form with at least 1/4 cup of fluids. Don't mix with caffeine, tea, or apple juice since it affects the absorption of Prolixin (fluphenazine).
Learn more
More about chlorpromazineSide effectsAlternativesFDA package insert
Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it
More about fluphenazineSide effectsAlternativesFDA package insert
Have you used Prolixin (fluphenazine)?
Worth itNot sureNot worth it