Compare chlorpromazine vs. fluphenazine decanoate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Stabilizes your mood.

Thorazine (chlorpromazine) has more side effects than other medicines like it. It is most useful during psychotic episodes because it slows you down quickly.

Treats schizophrenia or psychosis.

Prolixin Decanoate (fluphenazine decanoate) is long-acting medicine for stabilizing your mood that must be given by a trained healthcare professional.

Upsides
  • Acts fast to slow you down during a psychotic episode.
  • Can also be used for nausea or migraines.
  • Safe for use in children as young as 6 months.
  • Comes in a sugar-coated pill for easy administration.
  • Can be given less frequently than the oral, short-acting version.
  • Available in generic.
Downsides
  • Has more side effects than other medicines like it.
  • Can affect how your other medicines work.
  • Makes you more sensitive to the sun.
  • Can make you dizzy or lightheaded, especially when injected.
  • Cannot be stopped right away.
  • Can make you sensitive to the sun.
  • Can affect how your body regulates your temperature.
  • Can only be used if you're already stable on the short-acting version of this medicine.
Used for
Dosage forms
  • Pill
  • Injection
  • Injection
Price
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Reviews
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Side effects
The Thorazine (chlorpromazine) FDA package insert doesn’t have numbers about how common side effects are.
The Prolixin Decanoate (fluphenazine decanoate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Increased risk of death
    • People over 65 with dementia and psychosis
  • Difficulty controlling movements
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Breathing problems
    • Asthma
    • COPD
    • Acute respiratory infections
  • Heat stroke and dehydration
    • Benign prostatic hypertrophy (BPH)
    • Urinary retention
    • Decreased movement in the intestines
See more detailed risks and warnings
  • Increased risk of death
    • People over 65 with dementia and psychosis
  • Difficulty controlling movements
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Low white blood cell count
See more detailed risks and warnings